NFAT5 and TRIM14

Number of citations of the paper that reports this interaction (PubMedID 29053956)
0

Data Source:
BioGRID (two hybrid)

		NFAT5	TRIM14
Description		nuclear factor of activated T cells 5	tripartite motif containing 14
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity Ubiquitin Protein Ligase Activity
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Response To Stress DNA Damage Response Signal Transduction Positive Regulation Of Gene Expression Calcineurin-NFAT Signaling Cascade Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II R-loop Processing Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Cytokine Stimulus Cellular Hyperosmotic Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Immune System Process Inflammatory Response Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K48-linked Deubiquitination
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood osmolality (transformed sodium) ( 28360221) Blood urea nitrogen levels ( 31152163 29403010) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Chloride levels ( 29403010) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 31015462 30604766) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Hyperuricemia ( 29124443) Intralaminar thalamic nuclei volume ( 34006833) Menarche (age at onset) ( 21102462 27182965 25231870) Metabolic syndrome ( 31589552) Pulse pressure ( 27841878 28135244) Self-reported risk-taking behaviour ( 30181555) Serum uric acid levels ( 30993211 29124443) Sjögren's syndrome ( 28076899) Smoking initiation (ever regular vs never regular) ( 30679032) Sodium levels ( 29403010) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458 30297969) Urate levels ( 31985003 23263486)	Multiple sclerosis ( 31604244)
Interacting Genes		5 interacting genes: ABL1 FOXP3 NFE2L2 TBC1D4 TRIM14	85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652
Entrez ID		10725	9830
HPRD ID		05272	05948
Ensembl ID		ENSG00000102908	ENSG00000106785
Uniprot IDs		O94916	Q14142
PDB IDs		1IMH	6JBM
Enriched GO Terms of Interacting Partners?		Regulation Of Hematopoietic Stem Cell Differentiation Cellular Response To Fluid Shear Stress B Cell Homeostasis Regulation Of Hematopoietic Progenitor Cell Differentiation Response To Fluid Shear Stress Negative Regulation Of Endothelial Cell Apoptotic Process T Cell Proliferation Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Apoptotic Process Regulation Of Stem Cell Differentiation Alpha-beta T Cell Differentiation Leukocyte Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Interleukin-2 Production Negative Regulation Of DNA Recombination Lymphocyte Homeostasis Protein Localization To Cytoplasmic Microtubule Plus-end B Cell Activation Involved In Immune Response Positive Regulation Of Glutathione Biosynthetic Process Positive Regulation Of Peripheral T Cell Tolerance Induction Transitional One Stage B Cell Differentiation Alpha-beta T Cell Activation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Type II Interferon Production Podocyte Apoptotic Process DN4 Thymocyte Differentiation T Cell Receptor Signaling Pathway Response To Hydrogen Peroxide Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Lymphocyte Proliferation Cellular Response To Reactive Oxygen Species Inflammatory Response Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Establishment Of Endothelial Blood-brain Barrier Regulation Of Tolerance Induction Dependent Upon Immune Response CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment Mononuclear Cell Proliferation Lymphocyte Activation Involved In Immune Response Positive Regulation Of Neuron Projection Development Positive Regulation Of RNA Biosynthetic Process T Cell Differentiation Response To Reactive Oxygen Species Microspike Assembly Nicotinate-nucleotide Adenylyltransferase Activity Cell Activation Involved In Immune Response Antigen Receptor-mediated Signaling Pathway B-1 B Cell Homeostasis Negative Regulation Of DNA Metabolic Process
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