NFAT5

Gene Name		nuclear factor of activated T-cells 5, tonicity-responsive
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Cytokine Production Transcription From RNA Polymerase II Promoter Signal Transduction Excretion Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462) Urate levels ( 23263486)
Protein-protein Interactions		2 interactors: FOXP3 TBC1D4
Entrez ID		10725
HPRD ID		05272
Ensembl ID		ENSG00000102908
Uniprot IDs		O94916 Q7LA65
PDB IDs		1IMH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Peripheral T Cell Tolerance Induction Negative Regulation Of CREB Transcription Factor Activity Negative Regulation Of Transport Tolerance Induction To Self Antigen CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of T Cell Cytokine Production Negative Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Histone Deacetylation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Immature T Cell Proliferation Regulatory T Cell Differentiation Positive Regulation Of T Cell Anergy Negative Regulation Of Interleukin-4 Production Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Interleukin-5 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Vesicle Fusion Tolerance Induction Negative Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Interferon-gamma Biosynthetic Process Regulation Of T Cell Anergy Positive Regulation Of T Cell Tolerance Induction Negative Regulation Of Activated T Cell Proliferation Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Organelle Organization Negative Regulation Of Interleukin-2 Production Negative Regulation Of Histone Acetylation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Interleukin-4 Production Negative Regulation Of DNA Recombination Negative Regulation Of Protein Acetylation Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Peptidyl-lysine Acetylation Regulation Of T Cell Cytokine Production Positive Regulation Of Protein Acetylation Regulation Of Interleukin-5 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Interleukin-4 Production Regulation Of T Cell Differentiation In Thymus T Cell Mediated Immunity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Isotype Switching
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