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NFAT5 and TBC1D4
Number of citations of the paper that reports this interaction (PubMedID
12421765
)
39
Data Source:
HPRD
(two hybrid)
NFAT5
TBC1D4
Description
nuclear factor of activated T cells 5
TBC1 domain family member 4
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Cytoplasm
Cytosol
Cytoplasm
Golgi Apparatus
Cytosol
Vesicle
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
GTPase Activator Activity
Protein Binding
Biological Process
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Transcription By RNA Polymerase II
Response To Stress
DNA Damage Response
Signal Transduction
Positive Regulation Of Gene Expression
Calcineurin-NFAT Signaling Cascade
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
R-loop Processing
Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Cytokine Stimulus
Cellular Hyperosmotic Response
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Vesicle-mediated Transport
Negative Regulation Of Vesicle Fusion
Cellular Response To Insulin Stimulus
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Blood osmolality (transformed sodium) (
28360221
)
Blood urea nitrogen levels (
31152163
29403010
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Chloride levels (
29403010
)
Chronic kidney disease (
29124443
)
Creatinine levels (
29124443
)
Estimated glomerular filtration rate (
31015462
30604766
)
Hand grip strength (
29691431
)
Heel bone mineral density (
30598549
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Homeostasis model assessment of beta-cell function (dietary factor interaction) (
24204828
)
Hyperuricemia (
29124443
)
Intralaminar thalamic nuclei volume (
34006833
)
Menarche (age at onset) (
21102462
27182965
25231870
)
Metabolic syndrome (
31589552
)
Pulse pressure (
27841878
28135244
)
Self-reported risk-taking behaviour (
30181555
)
Serum uric acid levels (
30993211
29124443
)
Sjögren's syndrome (
28076899
)
Smoking initiation (ever regular vs never regular) (
30679032
)
Sodium levels (
29403010
)
Triglyceride levels (
32154731
)
Type 2 diabetes (
30054458
30297969
)
Urate levels (
31985003
23263486
)
Diabetic retinopathy (
23562823
)
Eosinophil count (
32888494
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Heart failure (
20445134
)
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
27863252
32888494
29403010
)
Mean platelet volume (
27863252
)
Mean reticulocyte volume (
32888494
)
Red blood cell count (
29403010
32888494
27863252
)
Serum alkaline phosphatase levels (
33547301
)
Two-hour glucose (
25043022
)
Type 2 diabetes (
29926116
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Interacting Genes
5 interacting genes:
ABL1
FOXP3
NFE2L2
TBC1D4
TRIM14
16 interacting genes:
AKT1
CDK5RAP2
EP400
FBXW11
LAMTOR5
NAV1
NFAT5
PIN1
RBM12
RESF1
TASOR
TET2
TOPBP1
U2SURP
YWHAG
ZMIZ1
Entrez ID
10725
9882
HPRD ID
05272
18164
Ensembl ID
ENSG00000102908
ENSG00000136111
Uniprot IDs
O94916
O60343
PDB IDs
1IMH
3QYB
7NIX
Enriched GO Terms of Interacting Partners
?
Regulation Of Hematopoietic Stem Cell Differentiation
Cellular Response To Fluid Shear Stress
B Cell Homeostasis
Regulation Of Hematopoietic Progenitor Cell Differentiation
Response To Fluid Shear Stress
Negative Regulation Of Endothelial Cell Apoptotic Process
T Cell Proliferation
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Endothelial Cell Apoptotic Process
Regulation Of Stem Cell Differentiation
Alpha-beta T Cell Differentiation
Leukocyte Homeostasis
Cellular Response To Hydrogen Peroxide
Regulation Of Interleukin-2 Production
Negative Regulation Of DNA Recombination
Lymphocyte Homeostasis
Protein Localization To Cytoplasmic Microtubule Plus-end
B Cell Activation Involved In Immune Response
Positive Regulation Of Glutathione Biosynthetic Process
Positive Regulation Of Peripheral T Cell Tolerance Induction
Transitional One Stage B Cell Differentiation
Alpha-beta T Cell Activation
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Type II Interferon Production
Podocyte Apoptotic Process
DN4 Thymocyte Differentiation
T Cell Receptor Signaling Pathway
Response To Hydrogen Peroxide
Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Endothelial Cell Migration
Lymphocyte Proliferation
Cellular Response To Reactive Oxygen Species
Inflammatory Response
Regulation Of Glutathione Biosynthetic Process
Aflatoxin Catabolic Process
Establishment Of Endothelial Blood-brain Barrier
Regulation Of Tolerance Induction Dependent Upon Immune Response
CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment
Mononuclear Cell Proliferation
Lymphocyte Activation Involved In Immune Response
Positive Regulation Of Neuron Projection Development
Positive Regulation Of RNA Biosynthetic Process
T Cell Differentiation
Response To Reactive Oxygen Species
Microspike Assembly
Nicotinate-nucleotide Adenylyltransferase Activity
Cell Activation Involved In Immune Response
Antigen Receptor-mediated Signaling Pathway
B-1 B Cell Homeostasis
Negative Regulation Of DNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Gene Expression
Positive Regulation Of Biosynthetic Process
Positive Regulation Of TORC1 Signaling
TORC1 Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Phosphorylation-dependent Protein Binding
Positive Regulation Of RNA Biosynthetic Process
TOR Signaling
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of TOR Signaling
Positive Regulation Of DNA-templated Transcription
Chromatin Organization
Positive Regulation Of RNA Metabolic Process
Regulation Of TORC1 Signaling
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Leukocyte Cell-cell Adhesion
Transposable Element Silencing By Heterochromatin Formation
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Protein Localization To Organelle
Positive Regulation Of Cell-cell Adhesion
Protein K6-linked Ubiquitination
Positive Regulation Of Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of TOR Signaling
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Protein Localization To Nucleus
Nucleus
Establishment Of Mitotic Spindle Orientation
Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Microtubule Cytoskeleton Organization
Transposable Element Silencing
Establishment Of Mitotic Spindle Localization
Establishment Of Spindle Orientation
Nucleoplasm
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Regulation Of TRNA Methylation
Cis-trans Isomerase Activity
Positive Regulation Of Cell Adhesion
Regulation Of Mitotic Cell Cycle
Regulation Of Cell-cell Adhesion
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Constitutive Heterochromatin Formation
Establishment Of Spindle Localization
Regulation Of Intracellular Signal Transduction
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Tagcloud (Intersection)
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