NFAT5 and TBC1D4

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		NFAT5	TBC1D4
Gene Name		nuclear factor of activated T-cells 5, tonicity-responsive	TBC1 domain family, member 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Rab GTPase Activator Activity
	Biological Process	Cytokine Production Transcription From RNA Polymerase II Promoter Signal Transduction Excretion Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Calcineurin-NFAT Signaling Cascade	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Positive Regulation Of Rab GTPase Activity Cellular Response To Insulin Stimulus Membrane Organization
Pathways			Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462) Urate levels ( 23263486)	Diabetic retinopathy ( 23562823) Heart failure ( 20445134)
Protein-Protein Interactions		2 interactors: FOXP3 TBC1D4	14 interactors: AKT1 CDK5RAP2 EP400 FAM208A KIAA1551 NAV1 NFAT5 PIN1 RBM12 TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		10725	9882
HPRD ID		05272	18164
Ensembl ID		ENSG00000102908	ENSG00000136111
Uniprot IDs		O94916 Q7LA65	O60343
PDB IDs		1IMH	3QYB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Peripheral T Cell Tolerance Induction Negative Regulation Of CREB Transcription Factor Activity Negative Regulation Of Transport Tolerance Induction To Self Antigen CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of T Cell Cytokine Production Negative Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Histone Deacetylation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Immature T Cell Proliferation Regulatory T Cell Differentiation Positive Regulation Of T Cell Anergy Negative Regulation Of Interleukin-4 Production Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Interleukin-5 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Vesicle Fusion Tolerance Induction Negative Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Interferon-gamma Biosynthetic Process Regulation Of T Cell Anergy Positive Regulation Of T Cell Tolerance Induction Negative Regulation Of Activated T Cell Proliferation Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Organelle Organization Negative Regulation Of Interleukin-2 Production Negative Regulation Of Histone Acetylation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Interleukin-4 Production Negative Regulation Of DNA Recombination Negative Regulation Of Protein Acetylation Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Peptidyl-lysine Acetylation Regulation Of T Cell Cytokine Production Positive Regulation Of Protein Acetylation Regulation Of Interleukin-5 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Interleukin-4 Production Regulation Of T Cell Differentiation In Thymus T Cell Mediated Immunity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Isotype Switching	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition Microtubule Bundle Formation Positive Regulation Of Mitochondrion Organization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process 5-methylcytosine Catabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Organelle Organization Peptidyl-amino Acid Modification Negative Regulation Of Phosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vitellogenesis Regulation Of Cell Cycle Process Organelle Organization G2/M Transition Of Mitotic Cell Cycle Cytosine Metabolic Process Regulation Of Neuron Differentiation Liver Morphogenesis Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Centriole Replication Hematopoietic Stem Cell Homeostasis Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of MAPK Cascade Response To UV-A Activation-induced Cell Death Of T Cells Oxidative DNA Demethylation Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Regulation Of Neurogenesis Myeloid Progenitor Cell Differentiation Cytoplasm Organization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Generation Of Neurons Cellular Response To Insulin Stimulus Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity
Tagcloud ?		0st 10b 130a 133a 27b 320b 34a 5p 7d adherens axon benzene ctnnb1 exiqon gnai2 guidance hsa integrating junction let mir mirna mirnas plcb1 poisoning smad4 tight totally vegfa	amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand
Tagcloud (Difference) ?		0st 10b 130a 133a 27b 320b 34a 5p 7d adherens axon benzene ctnnb1 exiqon gnai2 guidance hsa integrating junction let mir mirna mirnas plcb1 poisoning smad4 tight totally vegfa	amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand
Tagcloud (Intersection) ?