NFAT5 and FOXP3

Number of citations of the paper that reports this interaction (PMID 15790681)
96

Data Source:
HPRD (in vivo)

		NFAT5	FOXP3
Gene Name		nuclear factor of activated T-cells 5, tonicity-responsive	forkhead box P3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding
	Biological Process	Cytokine Production Transcription From RNA Polymerase II Promoter Signal Transduction Excretion Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Calcineurin-NFAT Signaling Cascade	Negative Regulation Of Transcription From RNA Polymerase II Promoter B Cell Homeostasis Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Mediated Immunity Tolerance Induction To Self Antigen Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction Chromatin Remodeling Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Histone Acetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Cytokine Biosynthetic Process T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Interleukin-2 Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cytokine Secretion Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462) Urate levels ( 23263486)
Protein-Protein Interactions		2 interactors: FOXP3 TBC1D4	9 interactors: EP300 IKZF4 KAT8 NFAT5 NFATC2 PRR20A RBPMS RUNX1 STUB1
Entrez ID		10725	50943
HPRD ID		05272	02242
Ensembl ID		ENSG00000102908	ENSG00000049768
Uniprot IDs		O94916 Q7LA65	Q9BZS1
PDB IDs		1IMH	3QRF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Peripheral T Cell Tolerance Induction Negative Regulation Of CREB Transcription Factor Activity Negative Regulation Of Transport Tolerance Induction To Self Antigen CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of T Cell Cytokine Production Negative Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Histone Deacetylation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Immature T Cell Proliferation Regulatory T Cell Differentiation Positive Regulation Of T Cell Anergy Negative Regulation Of Interleukin-4 Production Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Interleukin-5 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Vesicle Fusion Tolerance Induction Negative Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Interferon-gamma Biosynthetic Process Regulation Of T Cell Anergy Positive Regulation Of T Cell Tolerance Induction Negative Regulation Of Activated T Cell Proliferation Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Organelle Organization Negative Regulation Of Interleukin-2 Production Negative Regulation Of Histone Acetylation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Interleukin-4 Production Negative Regulation Of DNA Recombination Negative Regulation Of Protein Acetylation Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Peptidyl-lysine Acetylation Regulation Of T Cell Cytokine Production Positive Regulation Of Protein Acetylation Regulation Of Interleukin-5 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Interleukin-4 Production Regulation Of T Cell Differentiation In Thymus T Cell Mediated Immunity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Isotype Switching	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H2B Acetylation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Negative Regulation Of Gene Expression ER-nucleus Signaling Pathway Negative Regulation Of Biosynthetic Process Cellular Response To Topologically Incorrect Protein Histone Acetylation Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Progesterone Secretion Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Response To Unfolded Protein Protein Acetylation Regulation Of Signal Transduction Cytokine Production N-terminal Peptidyl-lysine Acetylation Regulation Of Progesterone Secretion
Tagcloud ?		0st 10b 130a 133a 27b 320b 34a 5p 7d adherens axon benzene ctnnb1 exiqon gnai2 guidance hsa integrating junction let mir mirna mirnas plcb1 poisoning smad4 tight totally vegfa	17a administrated asthmatic balf bas basophils bsyqf dex eos ethnopharmacological formulae hematoxylin hyperresponsiveness imbalance lym mch methacholine mon ova ovalbumin plex prominently qi rorgammat schiff shen th17 treg yi
Tagcloud (Difference) ?		0st 10b 130a 133a 27b 320b 34a 5p 7d adherens axon benzene ctnnb1 exiqon gnai2 guidance hsa integrating junction let mir mirna mirnas plcb1 poisoning smad4 tight totally vegfa	17a administrated asthmatic balf bas basophils bsyqf dex eos ethnopharmacological formulae hematoxylin hyperresponsiveness imbalance lym mch methacholine mon ova ovalbumin plex prominently qi rorgammat schiff shen th17 treg yi
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