S1PR4 and GNA12

Number of citations of the paper that reports this interaction (PMID 12761884)
14

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		S1PR4	GNA12
Gene Name		sphingosine-1-phosphate receptor 4	guanine nucleotide binding protein (G protein) alpha 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Brush Border Membrane
	Molecular Function	G-protein Coupled Receptor Activity Lipid Binding Sphingosine-1-phosphate Receptor Activity	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Sphingosine-1-phosphate Signaling Pathway Immune Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration	In Utero Embryonic Development G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Drug Embryonic Digit Morphogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors	Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling G alpha (12/13) signalling events Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Height ( 20881960 19343178 18391951 20189936) Ulcerative colitis ( 23128233 21297633) White matter integrity ( 23218918)
Protein-Protein Interactions		3 interactors: GNA12 GNA13 GNAI1	30 interactors: ACTB AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 RHOA S1PR4 S1PR5 TBXA2R TEC TSHR
Entrez ID		8698	2768
HPRD ID		04779	05093
Ensembl ID		ENSG00000125910	ENSG00000146535
Uniprot IDs		O95977	B3KXS2 E9PC54 Q03113 Q6ZQV4
PDB IDs		2DCO
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Rho Protein Signal Transduction Cell Activation Response To Wounding G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Shape Ras Protein Signal Transduction Regulation Of Cell Morphogenesis In Utero Embryonic Development Regulation Of Cell Migration Activation Of Phospholipase D Activity Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Fibroblast Migration Patterning Of Blood Vessels Vesicle Fusion Embryo Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of TOR Signaling Embryonic Digit Morphogenesis Organelle Fusion Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Signal Transduction Positive Regulation Of Lipase Activity Signaling Cell Communication Membrane Fusion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Embryonic Limb Morphogenesis	Platelet Activation Cell Surface Receptor Signaling Pathway Signaling Cell Communication Signal Transduction Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Cellular Response To Stimulus Cellular Calcium Ion Homeostasis Blood Coagulation Regulation Of Body Fluid Levels Calcium Ion Homeostasis Hemostasis Response To Organic Substance Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cellular Metal Ion Homeostasis Apoptotic Process Programmed Cell Death Cellular Cation Homeostasis Cellular Ion Homeostasis Cell Death Death Metal Ion Homeostasis Regulation Of Signaling Chemical Homeostasis Response To Stimulus Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Homeostatic Process Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Cellular Homeostasis Neurotrophin TRK Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To External Stimulus Neurotrophin Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Phospholipase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway
Tagcloud ?			anticipate arena atg16l1 card9 colitis crohn culminating forwards furthered gwa hnf4a ibds icoslg il10 il12b il1r2 il23 il23r irgm lamb1 nkx2 ormdl3 outlined paralleling prdm1 revolutionised successes theme ulcerative
Tagcloud (Difference) ?			anticipate arena atg16l1 card9 colitis crohn culminating forwards furthered gwa hnf4a ibds icoslg il10 il12b il1r2 il23 il23r irgm lamb1 nkx2 ormdl3 outlined paralleling prdm1 revolutionised successes theme ulcerative
Tagcloud (Intersection) ?