S1PR4

Name	sphingosine-1-phosphate receptor 4
Structure
Novel Interactors	1 novel interactors: TNFSF14
Interactors	4 interactors: GEMIN4 GNA12 GNA13 GNAI1
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Plasma Membrane Membrane Presynapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Sphingosine-1-phosphate Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways	G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs	Fingolimod
GWAS	Asthma ( 31959851 ) Basophil percentage of granulocytes ( 27863252 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 27863252 ) Mean platelet volume ( 32888494 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Plateletcrit ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum eosinophil basophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 32888494 29403010 27863252 )
Entrez ID	8698
HPRD ID	04779
Ensembl ID	ENSG00000125910
Uniprot IDs	O95977
PDB IDs	2DCO
GO Terms Enriched among Interactors ?	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding G Protein Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway T Cell Migration Regulation Of Fibroblast Migration GTPase Activity Brush Border Membrane GTP Binding Lymphocyte Migration Rho Protein Signal Transduction Mononuclear Cell Migration Regulation Of Cell Shape G Protein-coupled Receptor Signaling Pathway D2 Dopamine Receptor Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Regulation Of Blood Pressure Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Regulation Of Cell Migration Leukocyte Migration Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Cell Motility Regulation Of Cell Morphogenesis In Utero Embryonic Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Locomotion Small GTPase-mediated Signal Transduction Regulation Of Protein Localization To Cell Cortex Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway SMN Complex Gemini Of Cajal Bodies Cellular Response To Forskolin Regulation Of Relaxation Of Muscle T Cell Chemotaxis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Myoblast Fusion Small Nuclear Ribonucleoprotein Complex Response To Forskolin SMN-Sm Protein Complex