PROCR and VKORC1

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		PROCR	VKORC1
Gene Name		protein C receptor, endothelial	vitamin K epoxide reductase complex, subunit 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Centrosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Receptor Activity Protein Binding	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding
	Biological Process	Immune Response Blood Coagulation Antigen Processing And Presentation Negative Regulation Of Coagulation Leukocyte Migration	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development
Pathways		Common Pathway Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall	Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Drotrecogin alfa Phosphatidylethanolamine	Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Anticoagulant levels ( 22216198) Coagulation factor levels ( 20231535) D-dimer levels ( 21502573) Height ( 23563607) Hemostatic factors and hematological phenotypes ( 22443383) Protein C levels ( 20802025) Prothrombin time ( 22703881) Ulcerative colitis ( 23128233)	Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		3 interactors: DMTN PROC VKORC1	80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB
Entrez ID		10544	79001
HPRD ID		02801	10540
Ensembl ID		ENSG00000101000	ENSG00000167397
Uniprot IDs		Q9UNN8	Q9BQB6
PDB IDs		1L8J 1LQV 3JTC
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Regulation Of Wound Healing Positive Regulation Of Platelet Aggregation Post-translational Protein Modification Protein Secretion By Platelet Calcium-mediated Signaling Using Extracellular Calcium Source Actin Filament Reorganization Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Vitamin K Metabolic Process Positive Regulation Of Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Fibroblast Migration Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Body Fluid Levels Wound Healing Regulation Of Platelet Aggregation Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Focal Adhesion Assembly Response To Wounding Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Fibroblast Migration Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Cell-matrix Adhesion Peptidyl-amino Acid Modification Quinone Metabolic Process Drug Metabolic Process Positive Regulation Of Coagulation Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Focal Adhesion Assembly Positive Regulation Of Wound Healing Regulation Of Filopodium Assembly Cellular Response To Calcium Ion Cellular Response To CAMP Negative Regulation Of Cell-substrate Adhesion Actin Filament Capping Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Junction Assembly Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Wound Healing	Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport
Tagcloud ?		2132t carrying conditioned cords endothelial epcr functionality genotyped h1 h3h3 haplotype haplotypes intragenic intron isoform luciferase medium nucleotide pc polymorphism polymorphisms sepcr tagging thromboembolism truncated umbilical vein venous vte	arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Difference) ?		2132t carrying conditioned cords endothelial epcr functionality genotyped h1 h3h3 haplotype haplotypes intragenic intron isoform luciferase medium nucleotide pc polymorphism polymorphisms sepcr tagging thromboembolism truncated umbilical vein venous vte	arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Intersection) ?