PROCR

Gene Name		protein C receptor, endothelial
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Centrosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Protein Binding
	Biological Process	Immune Response Blood Coagulation Antigen Processing And Presentation Negative Regulation Of Coagulation Leukocyte Migration
Pathways		Common Pathway Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall
Drugs		Drotrecogin alfa Phosphatidylethanolamine
Diseases
GWAS		Anticoagulant levels ( 22216198) Coagulation factor levels ( 20231535) D-dimer levels ( 21502573) Height ( 23563607) Hemostatic factors and hematological phenotypes ( 22443383) Protein C levels ( 20802025) Prothrombin time ( 22703881) Ulcerative colitis ( 23128233)
Protein-protein Interactions		3 interactors: DMTN PROC VKORC1
Entrez ID		10544
HPRD ID		02801
Ensembl ID		ENSG00000101000
Uniprot IDs		Q9UNN8
PDB IDs		1L8J 1LQV 3JTC
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Regulation Of Wound Healing Positive Regulation Of Platelet Aggregation Post-translational Protein Modification Protein Secretion By Platelet Calcium-mediated Signaling Using Extracellular Calcium Source Actin Filament Reorganization Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Vitamin K Metabolic Process Positive Regulation Of Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Fibroblast Migration Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Body Fluid Levels Wound Healing Regulation Of Platelet Aggregation Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Focal Adhesion Assembly Response To Wounding Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Fibroblast Migration Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Cell-matrix Adhesion Peptidyl-amino Acid Modification Quinone Metabolic Process Drug Metabolic Process Positive Regulation Of Coagulation Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Focal Adhesion Assembly Positive Regulation Of Wound Healing Regulation Of Filopodium Assembly Cellular Response To Calcium Ion Cellular Response To CAMP Negative Regulation Of Cell-substrate Adhesion Actin Filament Capping Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Junction Assembly Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Wound Healing
Tagcloud ?		2132t carrying conditioned cords endothelial epcr functionality genotyped h1 h3h3 haplotype haplotypes intragenic intron isoform luciferase medium nucleotide pc polymorphism polymorphisms sepcr tagging thromboembolism truncated umbilical vein venous vte