PROCR

Description		protein C receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Centrosome Plasma Membrane Focal Adhesion Cell Surface Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity
	Biological Process	Blood Coagulation Hemostasis Negative Regulation Of Coagulation
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall
Drugs		Drotrecogin alfa Phosphatidylethanolamine Tetradecyl hydrogen sulfate (ester)
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anticoagulant levels ( 22216198) Appendicular lean mass ( 33097823) Coronary artery disease ( 29212778 33020668) D-dimer levels ( 21502573) Diastolic blood pressure ( 27618447) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Factor VII levels ( 20231535) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 23563607) Hemostatic factors and hematological phenotypes ( 22443383) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 33532862) Protein C levels ( 28082259 25376901 20802025) Prothrombin time ( 29403010 22703881) Thrombosis ( 26908601) Ulcerative colitis ( 23128233) Venous thromboembolism ( 25772935 31420334) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: DMTN PROC VKORC1
Entrez ID		10544
HPRD ID		02801
Ensembl ID		ENSG00000101000
Uniprot IDs		Q9UNN8
PDB IDs		1L8J 1LQV 3JTC 4V3D 4V3E 6SNY 7OKS 7OKT 7OKU 7OKV 7Q5D 8C44
Enriched GO Terms of Interacting Partners?		Regulation Of Wound Healing Regulation Of Response To Wounding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Coagulation Blood Coagulation Hemostasis Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Negative Regulation Of Protein Targeting To Membrane Positive Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Peptidyl-serine Phosphorylation Spectrin-associated Cytoskeleton Platelet Dense Tubular Network Membrane Quinone Binding Cell Projection Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Endoplasmic Reticulum Tubular Network Organization Regulation Of Biological Quality Smooth Endoplasmic Reticulum Positive Regulation Of Fibroblast Migration Negative Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Endothelial Barrier Endoplasmic Reticulum Calcium Ion Homeostasis Spectrin Binding Cortical Cytoskeleton Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Coagulation Erythrocyte Development Regulation Of Protein Targeting To Membrane Actin Filament Capping Lamellipodium Assembly Negative Regulation Of Cell-matrix Adhesion Regulation Of Lamellipodium Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Endothelial Cell Differentiation Regulation Of Fibroblast Migration Lamellipodium Organization Regulation Of Filopodium Assembly Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Actin Filament Depolymerization
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