PROCR and PROC

Number of citations of the paper that reports this interaction (PMID 10681521)
21

Data Source:
HPRD (in vitro)

		PROCR	PROC
Gene Name		protein C receptor, endothelial	protein C (inactivator of coagulation factors Va and VIIIa)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Centrosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Extracellular Vesicular Exosome	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen
	Molecular Function	Receptor Activity Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Immune Response Blood Coagulation Antigen Processing And Presentation Negative Regulation Of Coagulation Leukocyte Migration	Proteolysis Blood Coagulation Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Leukocyte Migration
Pathways		Common Pathway Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall	Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Removal of aminoterminal propeptides from gamma-carboxylated proteins Gamma-carboxylation of protein precursors Formation of Fibrin Clot (Clotting Cascade) Gamma carboxylation, hypusine formation and arylsulfatase activation Cell surface interactions at the vascular wall Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Drotrecogin alfa Phosphatidylethanolamine	Menadione Sodium Tetradecyl Sulfate
Diseases
GWAS		Anticoagulant levels ( 22216198) Coagulation factor levels ( 20231535) D-dimer levels ( 21502573) Height ( 23563607) Hemostatic factors and hematological phenotypes ( 22443383) Protein C levels ( 20802025) Prothrombin time ( 22703881) Ulcerative colitis ( 23128233)	Protein C levels ( 20802025)
Protein-Protein Interactions		3 interactors: DMTN PROC VKORC1	13 interactors: CP CSNK2B F2 F5 F8 GGCX PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		10544	5624
HPRD ID		02801	01466
Ensembl ID		ENSG00000101000	ENSG00000115718
Uniprot IDs		Q9UNN8	B4DPQ7 P04070
PDB IDs		1L8J 1LQV 3JTC	1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Regulation Of Wound Healing Positive Regulation Of Platelet Aggregation Post-translational Protein Modification Protein Secretion By Platelet Calcium-mediated Signaling Using Extracellular Calcium Source Actin Filament Reorganization Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Vitamin K Metabolic Process Positive Regulation Of Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Fibroblast Migration Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Body Fluid Levels Wound Healing Regulation Of Platelet Aggregation Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Focal Adhesion Assembly Response To Wounding Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Fibroblast Migration Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Cell-matrix Adhesion Peptidyl-amino Acid Modification Quinone Metabolic Process Drug Metabolic Process Positive Regulation Of Coagulation Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Focal Adhesion Assembly Positive Regulation Of Wound Healing Regulation Of Filopodium Assembly Cellular Response To Calcium Ion Cellular Response To CAMP Negative Regulation Of Cell-substrate Adhesion Actin Filament Capping Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Junction Assembly Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Wound Healing	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Coagulation Platelet Activation Platelet Degranulation Leukocyte Migration Negative Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Response To Stress Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Regulation Of Fibrinolysis Exocytosis Locomotion Negative Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Protein Processing Negative Regulation Of Platelet Activation Regulation Of Wound Healing Regulation Of Protein Processing Cell Migration Movement Of Cell Or Subcellular Component Cell Motility Fibrinolysis Secretion By Cell Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Post-translational Protein Modification Acute-phase Response Positive Regulation Of Coagulation Response To Stimulus Secretion Positive Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Fetal Process Involved In Parturition Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Acute Inflammatory Response Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Skeletal Muscle Cell Proliferation Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity
Tagcloud ?		2132t carrying conditioned cords endothelial epcr functionality genotyped h1 h3h3 haplotype haplotypes intragenic intron isoform luciferase medium nucleotide pc polymorphism polymorphisms sepcr tagging thromboembolism truncated umbilical vein venous vte	a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang
Tagcloud (Difference) ?		2132t carrying conditioned cords endothelial epcr functionality genotyped h1 h3h3 haplotype haplotypes intragenic intron isoform luciferase medium nucleotide pc polymorphism polymorphisms sepcr tagging thromboembolism truncated umbilical vein venous vte	a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang
Tagcloud (Intersection) ?