PROCR and DMTN

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PROCR	DMTN
Gene Name		protein C receptor, endothelial	dematin actin binding protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Centrosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Extracellular Vesicular Exosome	Cytosol Actin Filament Plasma Membrane Endomembrane System Spectrin-associated Cytoskeleton Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Cortical Cytoskeleton Platelet Dense Tubular Network Membrane Cell Projection Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Activity Protein Binding	Actin Binding Receptor Binding Protein Binding Spectrin Binding Protein Self-association
	Biological Process	Immune Response Blood Coagulation Antigen Processing And Presentation Negative Regulation Of Coagulation Leukocyte Migration	Protein Complex Assembly Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Fibroblast Migration Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Positive Regulation Of Blood Coagulation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Calcium-mediated Signaling Using Extracellular Calcium Source Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Actin Filament Bundle Assembly Regulation Of Filopodium Assembly Actin Filament Capping Negative Regulation Of Focal Adhesion Assembly Protein Secretion By Platelet Cellular Response To Calcium Ion Cellular Response To CAMP Positive Regulation Of Wound Healing Negative Regulation Of Protein Targeting To Membrane Actin Filament Reorganization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Common Pathway Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall
Drugs		Drotrecogin alfa Phosphatidylethanolamine
Diseases
GWAS		Anticoagulant levels ( 22216198) Coagulation factor levels ( 20231535) D-dimer levels ( 21502573) Height ( 23563607) Hemostatic factors and hematological phenotypes ( 22443383) Protein C levels ( 20802025) Prothrombin time ( 22703881) Ulcerative colitis ( 23128233)
Protein-Protein Interactions		3 interactors: DMTN PROC VKORC1	13 interactors: ACTB ACTC1 APP DYNC1LI2 EPB42 GOLGA2 NEDD4L PRKACA PROCR PTOV1 SNCA SNRPD2 SPTB
Entrez ID		10544	2039
HPRD ID		02801	00506
Ensembl ID		ENSG00000101000	ENSG00000158856
Uniprot IDs		Q9UNN8	B4DI75 Q08495
PDB IDs		1L8J 1LQV 3JTC	1QZP 1ZV6
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Regulation Of Wound Healing Positive Regulation Of Platelet Aggregation Post-translational Protein Modification Protein Secretion By Platelet Calcium-mediated Signaling Using Extracellular Calcium Source Actin Filament Reorganization Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Vitamin K Metabolic Process Positive Regulation Of Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Fibroblast Migration Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Body Fluid Levels Wound Healing Regulation Of Platelet Aggregation Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Focal Adhesion Assembly Response To Wounding Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Fibroblast Migration Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Cell-matrix Adhesion Peptidyl-amino Acid Modification Quinone Metabolic Process Drug Metabolic Process Positive Regulation Of Coagulation Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Focal Adhesion Assembly Positive Regulation Of Wound Healing Regulation Of Filopodium Assembly Cellular Response To Calcium Ion Cellular Response To CAMP Negative Regulation Of Cell-substrate Adhesion Actin Filament Capping Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Junction Assembly Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Wound Healing	Immune System Process Movement Of Cell Or Subcellular Component Regulation Of Tight Junction Assembly Cellular Response To Epinephrine Stimulus Response To Epinephrine Blood Coagulation Regulation Of Protein Binding Cell Maturation Hemostasis Regulation Of Ion Homeostasis Metal Ion Homeostasis Cellular Response To Catecholamine Stimulus Platelet Activation Ion Homeostasis Regulation Of Body Fluid Levels Cell Development Negative Regulation Of Transporter Activity Negative Regulation Of Nucleotide Metabolic Process Wound Healing Chemotaxis Regulation Of Binding Locomotion Cell Activation Immune Response Response To Wounding Regulation Of Cell Junction Assembly Water Homeostasis Homeostatic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Innate Immune Response Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Membrane Organization Chemical Homeostasis Extracellular Matrix Organization Extracellular Structure Organization Anatomical Structure Morphogenesis Response To Interleukin-1 Regulation Of Striated Muscle Contraction Regulation Of Phospholipase Activity Negative Regulation Of Protein Polymerization Axon Guidance Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Tagcloud ?		2132t carrying conditioned cords endothelial epcr functionality genotyped h1 h3h3 haplotype haplotypes intragenic intron isoform luciferase medium nucleotide pc polymorphism polymorphisms sepcr tagging thromboembolism truncated umbilical vein venous vte	apoe apolipoprotein app appl dementin developmental disrupted drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai tmcc2
Tagcloud (Difference) ?		2132t carrying conditioned cords endothelial epcr functionality genotyped h1 h3h3 haplotype haplotypes intragenic intron isoform luciferase medium nucleotide pc polymorphism polymorphisms sepcr tagging thromboembolism truncated umbilical vein venous vte	apoe apolipoprotein app appl dementin developmental disrupted drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai tmcc2
Tagcloud (Intersection) ?