RNGTT

Name	RNA guanylyltransferase and 5'-phosphatase
Structure
Novel Interactors	1 novel interactors: AP3B1
Interactors	4 interactors: APPBP2 CEBPA CRYAA RNMT
GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Catalytic Activity MRNA Guanylyltransferase Activity Polynucleotide 5'-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Binding ATP Binding GTP Binding RNA Guanylyltransferase Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Inorganic Triphosphate Phosphatase Activity MRNA 5'-triphosphate Monophosphatase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process 7-methylguanosine MRNA Capping RNA Processing MRNA Processing
Pathways	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE
GWAS	Colorectal or endometrial cancer ( 26621817 ) Depression in smokers ( 30219690 ) Graft survival time in renal transplantation (donor effect) ( 32080893 ) Height ( 31562340 ) Response to statin therapy ( 20339536 ) Simvastatin-induced myopathy ( 31220337 ) Subcutaneous adipose tissue ( 22589738 )
Entrez ID	8732
HPRD ID	04621
Ensembl ID	ENSG00000111880
Uniprot IDs	B4DSJ8 O60942
PDB IDs	2C46 3S24 8P4A 8P4B 8P4C 8P4D 8P4E 8W8E 8W8F
GO Terms Enriched among Interactors ?	Granulocyte Differentiation Mitochondrion Organization Lung Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission MRNA Capping Enzyme Complex MRNA 5'-cap (guanine-N7-)-methyltransferase Activity MRNA Cap Methyltransferase RNMT:RAMAC Complex RNA 5'-cap (guanine-N7)-methylation Myeloid Leukocyte Differentiation CHOP-C/EBP Complex Response To Phenylpropanoid White Fat Cell Proliferation Myeloid Cell Differentiation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Lens Fiber Cell Morphogenesis Cell Morphogenesis Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Regulation Of NK T Cell Differentiation 7-methylguanosine MRNA Capping RNA (guanine-N7)-methylation Fat Cell Proliferation Microvesicle Leukocyte Differentiation Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding RNA Metabolic Process Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway Animal Organ Development Positive Regulation Of Cell Activation STAT Family Protein Binding Osteoblast Development Tubulin Complex Assembly Response To UV-A Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Anterograde Synaptic Vesicle Transport AP-3 Adaptor Complex