RRS1 and FXYD2

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		RRS1	FXYD2
Description		regulator of ribosome synthesis 1	FXYD domain containing ion transport regulator 2
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum Preribosome, Large Subunit Precursor	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Basolateral Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding 5S RRNA Binding	ATPase Activator Activity Protein Binding Sodium Channel Regulator Activity Protein-macromolecule Adaptor Activity Ion Channel Regulator Activity
	Biological Process	Ribosomal Large Subunit Assembly Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Hematopoietic Progenitor Cell Differentiation Mitotic Metaphase Chromosome Alignment Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Regulation Of Signal Transduction By P53 Class Mediator Protein Localization To Nucleolus	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Negative Regulation Of Cell Population Proliferation Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Cellular Hyperosmotic Salinity Response Inorganic Cation Transmembrane Transport Proton Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways			Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Cyclothiazide Bisacodyl Thimerosal Tegoprazan
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: APPBP2 CFTR FXYD2 OGT SDCBP	6 interacting genes: ATP1A1 ERGIC3 RRS1 SGTA SLC22A1 SLC22A2
Entrez ID		23212	486
HPRD ID		15277	03487
Ensembl ID		ENSG00000179041	ENSG00000137731
Uniprot IDs		Q15050	P54710
PDB IDs		8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FL0 8IR1 8IR3 8RL2	2MKV 7E1Z 7E20 7E21
Enriched GO Terms of Interacting Partners?		Intracellular Chemical Homeostasis Positive Regulation Of Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Interleukin-5 Receptor Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cellular Homeostasis Positive Regulation Of Transport Chemical Homeostasis Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Exocytosis Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Interleukin-5 Receptor Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Protein O-acetylglucosaminyltransferase Activity Hyperosmotic Salinity Response Ion Channel Regulator Activity Cellular Hyperosmotic Salinity Response Basolateral Plasma Membrane Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Extracellular Exosome Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Sodium Ion Export Across Plasma Membrane Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Salt Stress Amelogenesis Positive Regulation Of Secretion By Cell ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Substrate-dependent Cell Migration, Cell Extension Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By Glucose Establishment Or Maintenance Of Transmembrane Electrochemical Gradient	Acetylcholine Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Neurotransmitter Transmembrane Transporter Activity Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Dopamine Transport Neurotransmitter Reuptake Xenobiotic Transmembrane Transporter Activity Monoamine Transport Neurotransmitter Uptake Basolateral Plasma Membrane Purine-containing Compound Transmembrane Transport Vitamin Transport Xenobiotic Transport Circulatory System Process Export Across Plasma Membrane Apical Plasma Membrane Basal Plasma Membrane Lateral Plasma Membrane Transport Across Blood-brain Barrier Organic Cation Transport Fatty Acid Transport
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