SYT1 and S100A13

Number of citations of the paper that reports this interaction (PMID 11432880)
27

Data Source:
BioGRID (biochemical, pull down)
HPRD (in vitro, in vivo)

		SYT1	S100A13
Gene Name		synaptotagmin I	S100 calcium binding protein A13
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule SNARE Complex Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane	Extracellular Space Nucleus Cytoplasm Cytosol Mast Cell Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	SNARE Binding Phosphatidylserine Binding Transporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Syntaxin-1 Binding Clathrin Binding Identical Protein Binding Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Lipid Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity RAGE Receptor Binding
	Biological Process	Detection Of Calcium Ion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Glutamate Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Positive Regulation Of Synaptic Transmission Protein Homooligomerization Regulation Of Synaptic Transmission, Glutamatergic Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway	Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mast Cell Degranulation Response To Copper Ion Cytokine Secretion Interleukin-1 Alpha Secretion Response To Electrical Stimulus
Pathways		Dopamine Neurotransmitter Release Cycle Toxicity of botulinum toxin type G (BoNT/G) Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			Olopatadine Amlexanox
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		30 interactors: CACNA1A CACNB3 CACNB4 CALM1 FGF1 GNB2L1 GOLM1 IKBKG IRF3 NEDD4 NR1H3 NR3C1 NRXN1 PPARG RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A ZDHHC17	7 interactors: FGF1 IGBP1 IL1A IRF9 PHYHIP PLEKHF2 SYT1
Entrez ID		6857	6284
HPRD ID		01710	03586
Ensembl ID		ENSG00000067715	ENSG00000189171
Uniprot IDs		J3KQA0 P21579	Q99584
PDB IDs		2K45 2K4A 2K8M 2KI6 2LHA 2R83 3F00 3F01 3F04 3F05 4ISQ	1YUR 1YUS 1YUT 1YUU 2EGD 2H2K 2K8M 2KI4 2KI6 2KOT 2L5X 2LE9
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Neurotransmitter Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Vesicle Localization Regulation Of Cellular Localization Exocytosis Regulation Of Signaling Organelle Localization Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Signaling Establishment Of Vesicle Localization Regulation Of Cellular Component Organization Cell Communication Establishment Of Localization In Cell Intracellular Receptor Signaling Pathway Cellular Localization Establishment Of Organelle Localization Vesicle Fusion Vesicle-mediated Transport Membrane Depolarization Membrane Fusion Acid Secretion Regulation Of Vesicle-mediated Transport Protein Localization Regulation Of Protein Localization Regulation Of Membrane Potential Organelle Fusion Regulation Of Secretion Glucocorticoid Receptor Signaling Pathway Regulation Of Immune Response Vesicle Docking Transport Regulation Of Synaptic Transmission Establishment Of Protein Localization Membrane Docking Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Calcium Ion-dependent Exocytosis Regulation Of Protein Secretion Regulation Of Cellular Process Cell Differentiation Protein Transport Regulation Of Protein Localization To Plasma Membrane Membrane Organization	Cellular Response To Heat Branch Elongation Involved In Ureteric Bud Branching Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Response To Heat Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Division Response To Cytokine Immune System Process Regulation Of Stress-activated MAPK Cascade Response To Temperature Stimulus Regulation Of ERK1 And ERK2 Cascade Fever Generation Calcium Ion-dependent Exocytosis Of Neurotransmitter Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Ureteric Bud Elongation Regulation Of Angiogenesis Negative Regulation Of Protein Dephosphorylation Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Heat Generation Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Division Wound Healing Involved In Inflammatory Response Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Secretion Response To Metal Ion Type I Interferon Biosynthetic Process Immune Response Regulation Of Phosphorylation Detection Of Calcium Ion Positive Regulation Of Transcription, DNA-templated Defense Response Regulation Of Signaling Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Microtubule-based Movement Signaling Positive Regulation Of Interleukin-2 Biosynthetic Process Cell Communication Type I Interferon Production Positive Regulation Of Organelle Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Vesicle Fusion Positive Regulation Of Gene Expression Positive Regulation Of MAPK Cascade
Tagcloud ?		carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes	anchor bilayer biophysical biphasic c2b calorimetry cu2 destabilized endothermic exothermic fgf1 isothermal itc lacks marginally mrc multiprotein nonclassical p40 phosphatidyl pockets proangiogenic ps synaptotagmin syt1 tb3 titration unilamellar vesicles
Tagcloud (Difference) ?		carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes	anchor bilayer biophysical biphasic c2b calorimetry cu2 destabilized endothermic exothermic fgf1 isothermal itc lacks marginally mrc multiprotein nonclassical p40 phosphatidyl pockets proangiogenic ps synaptotagmin tb3 titration unilamellar vesicles
Tagcloud (Intersection) ?		syt1