SYT1 and NRXN1

Number of citations of the paper that reports this interaction (PubMedID 8901523)
0

Data Source:
HPRD (in vitro)

		SYT1	NRXN1
Description		synaptotagmin 1	neurexin 1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Synaptic Vesicle Postsynaptic Density Membrane Secretory Granule Axon Transport Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Neuron Projection Terminus Synapse Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Nucleolus Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Endocytic Vesicle Neuromuscular Junction Nuclear Membrane Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body Axonal Growth Cone Synapse Protein Complex Involved In Cell-cell Adhesion Presynapse Trans-synaptic Protein Complex Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Syntaxin-1 Binding Syntaxin Binding Clathrin Binding Syntaxin-3 Binding Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding Calcium Ion Sensor Activity Molecular Condensate Scaffold Activity	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Signaling Receptor Activity Metal Ion Binding Calcium-dependent Protein Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Detection Of Calcium Ion Vesicle Fusion Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Dopamine Secretion Vesicle Organization Synaptic Vesicle Exocytosis Vesicle-mediated Transport Regulation Of Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Regulation Of Vesicle Fusion Positive Regulation Of Vesicle Fusion Positive Regulation Of Dopamine Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Protein Heterooligomerization Response To Calcium Ion Regulation Of Synaptic Transmission, Glutamatergic Spontaneous Neurotransmitter Secretion Cellular Response To Calcium Ion Synchronous Neurotransmitter Secretion Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium-dependent Activation Of Synaptic Vesicle Fusion Membraneless Organelle Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis	Angiogenesis Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebellar Granule Cell Differentiation Neuronal Signal Transduction Adult Behavior Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Social Behavior Protein Localization To Synapse Vocal Learning Positive Regulation Of CAMP-mediated Signaling Establishment Of Protein Localization Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Neuromuscular Process Controlling Balance Negative Regulation Of Filopodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Vocalization Behavior Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Synapse Maturation Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gamma-aminobutyric Acid Receptor Clustering NMDA Glutamate Receptor Clustering Gephyrin Clustering Involved In Postsynaptic Density Assembly Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse NMDA Selective Glutamate Receptor Signaling Pathway AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Neuromuscular Synaptic Transmission Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type G (botG) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation	Neurexins and neuroligins Neurexins and neuroligins Non-integrin membrane-ECM interactions Neurexins and neuroligins Neurexins and neuroligins
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Adiponectin levels ( 33562295) Brain morphology (MOSTest) ( 32665545) Chloride levels ( 29403010) Estimated glomerular filtration rate ( 31217584) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Hand grip strength ( 29313844) Intelligence (MTAG) ( 29326435) Lung function ( 31902109) Lysophosphatidylcholine levels ( 31551469) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) QRS duration ( 31251759) Sodium levels ( 29403010) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Body mass index ( 28892062) Chromosomal aberration frequency (chromatid type) ( 31586183) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Educational attainment ( 25201988) General risk tolerance (MTAG) ( 30643258) Isovolumetric relaxation time ( 28394258) Lateral ventricle temporal horn volume ( 31530798) Longevity ( 20834067) Lung cancer in ever smokers ( 28604730) Metabolite levels (HVA/MHPG ratio) ( 23319000) Morning person ( 30696823) Nicotine dependence symptom count ( 25555482) Personality dimensions ( 20691247) Post bronchodilator FEV1/FVC ratio ( 26634245) Recurrent major depressive disorder ( 34099189) Refractive astigmatism ( 25367360) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Severe gingival inflammation ( 28459102) Smoking initiation ( 33082346) Systolic blood pressure ( 30578418 30224653) Temperament ( 22832960) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Triglyceride levels ( 32203549) Word spelling ( 30741946)
Interacting Genes		46 interacting genes: BNIP2 BTN2A2 CACNA1A CACNB3 CACNB4 CALM1 CREBBP CSGALNACT2 CYB5B DANCR FGF1 GIMAP5 GOLM1 HMOX2 IKBKG IRF3 MIP NAPB NEDD4 NR1H3 NR3C1 NRXN1 PPARG RACK1 RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A TMEM14C TMEM254 TMEM60 TSHR UBIAD1 ZDHHC17 ZFPL1	28 interacting genes: AFDN APBA1 APBA2 ATP13A2 CASK MACF1 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3
Entrez ID		6857	9378
HPRD ID		01710	11858
Ensembl ID		ENSG00000067715	ENSG00000179915
Uniprot IDs		J3KQA0 P21579	A0A0D9SEM5 A0A0D9SEQ7 A0A1D5RMU6 E7EQN4 H0Y568 H7BYC7 P58400 Q9ULB1
PDB IDs		2K45 2K4A 2K8M 2KI6 2LHA 2N1T 2R83 3F00 3F01 3F04 3F05 4ISQ 4V11 6G5F 6G5K 6QNS 6TZ3 6U41 6U4U 6U4W 6ZVN 7TUA 7TX9 7U4Q 8B8I	3B3Q 5Z8Y 6NID
Enriched GO Terms of Interacting Partners?		Neurotransmitter Transport Organelle Localization By Membrane Tethering Modulation Of Chemical Synaptic Transmission Membrane Docking Vesicle Docking SNARE Binding Organelle Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling SNAP Receptor Activity Calcium-dependent Protein Binding Secretion By Cell Secretion SNARE Complex Vesicle-mediated Transport In Synapse Membrane Fusion Vesicle Fusion Regulation Of Cell Communication Regulation Of Signaling Organelle Membrane Fusion Synapse Regulation Of Regulated Secretory Pathway Exocytosis Vesicle-mediated Transport Organelle Fusion Chemical Synaptic Transmission Glutamatergic Synapse Positive Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Trans-synaptic Signaling Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Neurotransmitter Secretion Regulation Of Protein Localization Synaptic Signaling Regulation Of Biological Quality Synaptic Vesicle Docking Signal Release Establishment Of Localization In Cell Calcium Channel Regulator Activity Positive Regulation Of Immune Response Regulation Of Synaptic Vesicle Exocytosis Regulation Of Exocytosis Somatodendritic Compartment Regulation Of Vesicle-mediated Transport Activation Of Immune Response Long-term Synaptic Potentiation Regulation Of Secretion By Cell Regulation Of Membrane Potential Cell-cell Signaling Presynaptic Membrane	Exocytic Vesicle Calcium-dependent Activation Of Synaptic Vesicle Fusion Calcium-dependent Phospholipid Binding Calcium Ion Sensor Activity Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Calcium Ion-dependent Exocytosis Neurexin Family Protein Binding Regulation Of Regulated Secretory Pathway Regulation Of Exocytosis Modulation Of Chemical Synaptic Transmission Dense Core Granule Regulation Of Vesicle Fusion SNARE Binding Synaptic Vesicle Membrane Regulation Of Synaptic Vesicle Exocytosis Regulation Of Secretion By Cell Regulation Of Secretion Plasma Membrane Regulation Of Vesicle-mediated Transport Phosphatidylinositol-4,5-bisphosphate Binding Synapse Regulation Of Neurotransmitter Secretion Positive Regulation Of Transport Positive Regulation Of Exocytosis Secretion By Cell Vesicle-mediated Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Regulated Secretory Pathway Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Secretion Positive Regulation Of Cellular Component Organization Postsynaptic Membrane Assembly Excitatory Synapse Neuron To Neuron Synapse Clathrin Binding Cellular Localization Postsynaptic Membrane Organization Presynaptic Membrane Assembly Cell-cell Signaling Positive Regulation Of Secretion By Cell Presynaptic Membrane Organization Regulation Of Transport Signaling Cytoplasmic Vesicle Positive Regulation Of Secretion Cell Communication Exocytosis
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