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SYT1 and IKBKG
Number of citations of the paper that reports this interaction (PubMedID
20098747
)
50
Data Source:
BioGRID
(two hybrid)
SYT1
IKBKG
Description
synaptotagmin 1
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Plasma Membrane
Synaptic Vesicle
Postsynaptic Density
Membrane
Secretory Granule
Axon
Transport Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Synaptic Vesicle Membrane
Dense Core Granule
Cytoplasmic Vesicle
Chromaffin Granule Membrane
Presynaptic Membrane
Neuron Projection
Neuron Projection Terminus
Synapse
Postsynaptic Membrane
Presynaptic Active Zone
Excitatory Synapse
Clathrin-sculpted Acetylcholine Transport Vesicle Membrane
Clathrin-sculpted Glutamate Transport Vesicle Membrane
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
Clathrin-sculpted Monoamine Transport Vesicle Membrane
Exocytic Vesicle
Hippocampal Mossy Fiber To CA3 Synapse
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Ubiquitin Ligase Complex
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Protein-containing Complex
Mitotic Spindle
Molecular Function
SNARE Binding
Phosphatidylserine Binding
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Phospholipid Binding
Calcium-dependent Phospholipid Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Lipid Binding
Syntaxin-1 Binding
Syntaxin Binding
Clathrin Binding
Syntaxin-3 Binding
Identical Protein Binding
Metal Ion Binding
Protein Heterodimerization Activity
Calcium-dependent Protein Binding
Low-density Lipoprotein Particle Receptor Binding
Calcium Ion Sensor Activity
Molecular Condensate Scaffold Activity
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Linear Polyubiquitin Binding
Transferrin Receptor Binding
Biological Process
Detection Of Calcium Ion
Vesicle Fusion
Chemical Synaptic Transmission
Neurotransmitter Secretion
Regulation Of Dopamine Secretion
Vesicle Organization
Synaptic Vesicle Exocytosis
Vesicle-mediated Transport
Regulation Of Exocytosis
Regulation Of Calcium Ion-dependent Exocytosis
Cell Differentiation
Regulation Of Vesicle Fusion
Positive Regulation Of Vesicle Fusion
Positive Regulation Of Dopamine Secretion
Positive Regulation Of Calcium Ion-dependent Exocytosis
Vesicle Docking
Calcium Ion-regulated Exocytosis Of Neurotransmitter
Positive Regulation Of Synaptic Transmission
Protein Heterooligomerization
Response To Calcium Ion
Regulation Of Synaptic Transmission, Glutamatergic
Spontaneous Neurotransmitter Secretion
Cellular Response To Calcium Ion
Synchronous Neurotransmitter Secretion
Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter
Calcium-dependent Activation Of Synaptic Vesicle Fusion
Membraneless Organelle Assembly
Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
Regulation Of Regulated Secretory Pathway
Positive Regulation Of Dendrite Extension
Regulation Of Synaptic Vesicle Exocytosis
B Cell Homeostasis
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Response
Immune Response
DNA Damage Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Anoikis
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Establishment Of Vesicle Localization
Protein-containing Complex Assembly
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Toxicity of botulinum toxin type B (botB)
Toxicity of botulinum toxin type G (botG)
Neurexins and neuroligins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
GABA synthesis, release, reuptake and degradation
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SUMOylation of immune response proteins
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ub-specific processing proteases
Ovarian tumor domain proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Drugs
AGRO100
Tarenflurbil
Diseases
Incontinentia pigmenti
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
GWAS
Adiponectin levels (
33562295
)
Brain morphology (MOSTest) (
32665545
)
Chloride levels (
29403010
)
Estimated glomerular filtration rate (
31217584
)
Fasting insulin (
34059833
)
General cognitive ability (
29844566
)
Hand grip strength (
29313844
)
Intelligence (MTAG) (
29326435
)
Lung function (
31902109
)
Lysophosphatidylcholine levels (
31551469
)
Obesity-related traits (
23251661
)
Pulse pressure (
30578418
)
QRS duration (
31251759
)
Sodium levels (
29403010
)
Systemic lupus erythematosus (
28714469
)
Systolic blood pressure (
30224653
)
Hemoglobin levels (
26366553
)
Interacting Genes
46 interacting genes:
BNIP2
BTN2A2
CACNA1A
CACNB3
CACNB4
CALM1
CREBBP
CSGALNACT2
CYB5B
DANCR
FGF1
GIMAP5
GOLM1
HMOX2
IKBKG
IRF3
MIP
NAPB
NEDD4
NR1H3
NR3C1
NRXN1
PPARG
RACK1
RBM14
RIMS1
S100A13
SIN3A
SMAD2
SNAP25
STON2
STX1A
STX2
STX3
STX4
SV2B
SYNCRIP
SYT4
TFAP2A
TMEM14C
TMEM254
TMEM60
TSHR
UBIAD1
ZDHHC17
ZFPL1
241 interacting genes:
ABCA1
ACBD6
ADAP2
AIP
ALK
AMMECR1L
APRT
ARF4
ARF5
ARF6
ARGLU1
ARHGDIA
ARL6IP4
ARPP19
AVPI1
BCL10
BIRC2
BRME1
C19orf12
CALB1
CARD10
CARD11
CARD8
CASP6
CASP8
CCHCR1
CDC37
CDK2
CDKN1A
CETN3
CHUK
CLIC1
CNOT7
COPS3
CPNE2
CREBBP
CUEDC1
CWF19L2
CYLD
DAPK1
DDIT3
DDX19B
DNAJC8
DYNC1LI1
EEF1A1
EGFR
EGLN3
EIF1AX
ENKD1
EPHA4
FADD
FGR
FLT3
FLT4
FRMD8
GADD45G
GADD45GIP1
GCC1
GEMIN2
GFAP
GIT2
GLO1
GNGT1
GPKOW
GRK4
GSK3B
GTF2E1
GUCY1A1
GYG2
H1-0
HBZ
HCLS1
HDDC2
HIF1A
HLA-DQA1
HPCAL1
HPD
HSP90AA1
HSP90AB1
HSPA1A
HSPA4
ID1
ID3
IKBKB
INO80E
IRAK1
IRAK4
ITK
JAK2
JAK3
KANSL2
KIR3DX1
KRT18
KRT8
LCK
LENG8
LGALS2
LMCD1
LPXN
LUC7L2
LZIC
LZTR1
MACROD1
MAFIP
MAP3K14
MAP3K2
MAPRE1
MARCHF2
MCM10
MCM7
MED7
MERTK
MLLT6
MPRIP
MYD88
MYL5
MYO5C
MZT2A
NAP1L5
NCOA3
NECAB3
NFKB1
NFKB2
NFKBIA
NFKBIB
NHP2
NRARP
NRBF2
NTMT1
ODAM
OSBPL10
OSGIN1
PA2G4
PARP1
PCK1
PDCL
PFDN5
PHF7
PIM2
PLEKHJ1
PNMA8A
POLR2B
POLR2D
POLR2E
POLR3A
PPM1B
PRKCB
PRKCI
PRKCQ
PRKD3
PRKDC
PRKN
PRPF18
PSMA3
PSMB5
RAB11A
RAB11B
RAB8A
RALBP1
RBBP8
RBM34
RBM8A
RBP1
RET
RHOA
RIPK1
RIPK2
RNF11
RNF31
RNF34
RNF4
RNF7
ROR2
ROS1
RPL41
RPS12
RPS6KB2
SCLT1
SENP2
SEPTIN9
SGK1
SHTN1
SLU7
SNW1
SRC
SRPK1
SSX2IP
STK25
STX11
SUPT5H
SYT1
TAB1
TAB2
TAB3
TAF7
TANK
TARBP2
TAX1BP1
TBC1D7
TBK1
TCEANC
TCP10L
TCP11
TCP11L1
TEC
TEK
TMA16
TNF
TNFAIP3
TNFRSF1A
TNIP1
TNIP2
TPT1
TRAF3IP2
TRIM29
TRIM31
TRIM37
TRIM41
TRIOBP
TRPC4AP
TSLP
TTYH2
TUBG1
TXLNA
TYRO3
UBASH3A
UBB
UBC
UBE2D3
UBE2D4
UBE2I
USP2
VAMP3
WDR5
WWP1
ZBTB3
ZC3H12A
ZFAND5
ZNF587
ZNF835
ZZZ3
Entrez ID
6857
8517
HPRD ID
01710
02217
Ensembl ID
ENSG00000067715
ENSG00000269335
Uniprot IDs
J3KQA0
P21579
A0A087X1B1
Q9Y6K9
PDB IDs
2K45
2K4A
2K8M
2KI6
2LHA
2N1T
2R83
3F00
3F01
3F04
3F05
4ISQ
4V11
6G5F
6G5K
6QNS
6TZ3
6U41
6U4U
6U4W
6ZVN
7TUA
7TX9
7U4Q
8B8I
2JVX
2JVY
3BRT
3BRV
3CL3
3FX0
4BWN
5AAY
5LDE
6MI3
6MI4
6XX0
6YEK
7T2U
7TV4
8U7C
9AZJ
Enriched GO Terms of Interacting Partners
?
Neurotransmitter Transport
Organelle Localization By Membrane Tethering
Modulation Of Chemical Synaptic Transmission
Membrane Docking
Vesicle Docking
SNARE Binding
Organelle Localization
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
SNAP Receptor Activity
Calcium-dependent Protein Binding
Secretion By Cell
Secretion
SNARE Complex
Vesicle-mediated Transport In Synapse
Membrane Fusion
Vesicle Fusion
Regulation Of Cell Communication
Regulation Of Signaling
Organelle Membrane Fusion
Synapse
Regulation Of Regulated Secretory Pathway
Exocytosis
Vesicle-mediated Transport
Organelle Fusion
Chemical Synaptic Transmission
Glutamatergic Synapse
Positive Regulation Of Signal Transduction
Positive Regulation Of Synaptic Transmission
Trans-synaptic Signaling
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Neurotransmitter Secretion
Regulation Of Protein Localization
Synaptic Signaling
Regulation Of Biological Quality
Synaptic Vesicle Docking
Signal Release
Establishment Of Localization In Cell
Calcium Channel Regulator Activity
Positive Regulation Of Immune Response
Regulation Of Synaptic Vesicle Exocytosis
Regulation Of Exocytosis
Somatodendritic Compartment
Regulation Of Vesicle-mediated Transport
Activation Of Immune Response
Long-term Synaptic Potentiation
Regulation Of Secretion By Cell
Regulation Of Membrane Potential
Cell-cell Signaling
Presynaptic Membrane
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cytoplasm
Protein Kinase Activity
Non-canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cytosol
Canonical NF-kappaB Signal Transduction
Kinase Activity
Regulation Of Immune Response
Regulation Of Innate Immune Response
Regulation Of Defense Response
Activation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Activation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Regulation Of Apoptotic Process
Positive Regulation Of Signaling
Intracellular Signal Transduction
Positive Regulation Of Innate Immune Response
Immune Response-activating Signaling Pathway
Protein Modification Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Immune Response-regulating Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Nucleotide Binding
Transferase Activity
Positive Regulation Of Cell Communication
Innate Immune Response-activating Signaling Pathway
Macromolecule Metabolic Process
Protein Tyrosine Kinase Activity
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Cytokine-mediated Signaling Pathway
Intracellular Receptor Signaling Pathway
Regulation Of Immune System Process
Protein Phosphorylation
Protein Binding
Regulation Of Protein Modification Process
Protein Metabolic Process
ATP Binding
Negative Regulation Of Programmed Cell Death
Phosphorylation
Nucleus
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Tagcloud (Intersection)
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