SYT1 and TFAP2A

Number of citations of the paper that reports this interaction (PMID 8087843)
87

Data Source:
HPRD (in vitro)

		SYT1	TFAP2A
Gene Name		synaptotagmin I	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule SNARE Complex Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Intracellular Membrane-bounded Organelle
	Molecular Function	SNARE Binding Phosphatidylserine Binding Transporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Syntaxin-1 Binding Clathrin Binding Identical Protein Binding Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Transcription Coactivator Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Detection Of Calcium Ion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Glutamate Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Positive Regulation Of Synaptic Transmission Protein Homooligomerization Regulation Of Synaptic Transmission, Glutamatergic Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Outflow Tract Morphogenesis Keratinocyte Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Transcription From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Embryonic Body Morphogenesis Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Neural Crest Cell Development Anterior Neuropore Closure Trigeminal Nerve Development Oculomotor Nerve Formation Forebrain Neuron Development Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Embryonic Cranial Skeleton Morphogenesis Epidermis Morphogenesis Palate Development Lens Induction In Camera-type Eye Face Morphogenesis Bone Morphogenesis Eyelid Development In Camera-type Eye Cornea Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Basement Membrane Organization Metanephric Nephron Development Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Dopamine Neurotransmitter Release Cycle Toxicity of botulinum toxin type G (BoNT/G) Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		30 interactors: CACNA1A CACNB3 CACNB4 CALM1 FGF1 GNB2L1 GOLM1 IKBKG IRF3 NEDD4 NR1H3 NR3C1 NRXN1 PPARG RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A ZDHHC17	30 interactors: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CTNNB1 DEK EP300 EPN2 EPS15 GSTO2 HIP1 LDLRAP1 MAGI1 MKRN3 MYC NPM1 PPARG RB1 SP1 SRA1 SUMO4 SYT1 TP53 UBE2I WWP1 WWP2 YBX1
Entrez ID		6857	7020
HPRD ID		01710	00128
Ensembl ID		ENSG00000067715	ENSG00000137203
Uniprot IDs		J3KQA0 P21579	P05549
PDB IDs		2K45 2K4A 2K8M 2KI6 2LHA 2R83 3F00 3F01 3F04 3F05 4ISQ
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Neurotransmitter Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Vesicle Localization Regulation Of Cellular Localization Exocytosis Regulation Of Signaling Organelle Localization Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Signaling Establishment Of Vesicle Localization Regulation Of Cellular Component Organization Cell Communication Establishment Of Localization In Cell Intracellular Receptor Signaling Pathway Cellular Localization Establishment Of Organelle Localization Vesicle Fusion Vesicle-mediated Transport Membrane Depolarization Membrane Fusion Acid Secretion Regulation Of Vesicle-mediated Transport Protein Localization Regulation Of Protein Localization Regulation Of Membrane Potential Organelle Fusion Regulation Of Secretion Glucocorticoid Receptor Signaling Pathway Regulation Of Immune Response Vesicle Docking Transport Regulation Of Synaptic Transmission Establishment Of Protein Localization Membrane Docking Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Calcium Ion-dependent Exocytosis Regulation Of Protein Secretion Regulation Of Cellular Process Cell Differentiation Protein Transport Regulation Of Protein Localization To Plasma Membrane Membrane Organization	Cell Death Death Apoptotic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Viral Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Execution Phase Of Apoptosis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Glial Cell Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Peptidase Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Cell Proliferation Regulation Of Cell Cycle Neuron Death Positive Regulation Of Gene Expression Regulation Of Cell Death Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Immune System Development Positive Regulation Of Proteolysis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes	blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas thap11 tscs
Tagcloud (Difference) ?		carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes	blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas thap11 tscs
Tagcloud (Intersection) ?