SYT1 and STON2

Number of citations of the paper that reports this interaction (PubMedID 11381094)
50

Data Source:
HPRD (in vitro)

		SYT1	STON2
Description		synaptotagmin 1	stonin 2
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Synaptic Vesicle Postsynaptic Density Membrane Secretory Granule Axon Transport Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Neuron Projection Terminus Synapse Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Nucleolus Cytoplasm Cytosol Synaptic Vesicle Membrane AP-2 Adaptor Complex Neuron Projection Synapse
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Syntaxin-1 Binding Syntaxin Binding Clathrin Binding Syntaxin-3 Binding Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding Calcium Ion Sensor Activity Molecular Condensate Scaffold Activity	Protein Binding Clathrin Adaptor Activity
	Biological Process	Detection Of Calcium Ion Vesicle Fusion Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Dopamine Secretion Vesicle Organization Synaptic Vesicle Exocytosis Vesicle-mediated Transport Regulation Of Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Regulation Of Vesicle Fusion Positive Regulation Of Vesicle Fusion Positive Regulation Of Dopamine Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Protein Heterooligomerization Response To Calcium Ion Regulation Of Synaptic Transmission, Glutamatergic Spontaneous Neurotransmitter Secretion Cellular Response To Calcium Ion Synchronous Neurotransmitter Secretion Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium-dependent Activation Of Synaptic Vesicle Fusion Membraneless Organelle Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis	Endocytosis Regulation Of Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type G (botG) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Adiponectin levels ( 33562295) Brain morphology (MOSTest) ( 32665545) Chloride levels ( 29403010) Estimated glomerular filtration rate ( 31217584) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Hand grip strength ( 29313844) Intelligence (MTAG) ( 29326435) Lung function ( 31902109) Lysophosphatidylcholine levels ( 31551469) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) QRS duration ( 31251759) Sodium levels ( 29403010) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653)	Central corneal thickness ( 29760442 32528159) Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Prudent dietary pattern ( 28644415)
Interacting Genes		46 interacting genes: BNIP2 BTN2A2 CACNA1A CACNB3 CACNB4 CALM1 CREBBP CSGALNACT2 CYB5B DANCR FGF1 GIMAP5 GOLM1 HMOX2 IKBKG IRF3 MIP NAPB NEDD4 NR1H3 NR3C1 NRXN1 PPARG RACK1 RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A TMEM14C TMEM254 TMEM60 TSHR UBIAD1 ZDHHC17 ZFPL1	8 interacting genes: AP2M1 EPS15 EPS15L1 H19 ITSN1 SYT1 SYT2 UBC
Entrez ID		6857	85439
HPRD ID		01710	10531
Ensembl ID		ENSG00000067715	ENSG00000140022
Uniprot IDs		J3KQA0 P21579	A0A3B3IU55 H0YJ05 Q8WXE9
PDB IDs		2K45 2K4A 2K8M 2KI6 2LHA 2N1T 2R83 3F00 3F01 3F04 3F05 4ISQ 4V11 6G5F 6G5K 6QNS 6TZ3 6U41 6U4U 6U4W 6ZVN 7TUA 7TX9 7U4Q 8B8I	2JXC
Enriched GO Terms of Interacting Partners?		Neurotransmitter Transport Organelle Localization By Membrane Tethering Modulation Of Chemical Synaptic Transmission Membrane Docking Vesicle Docking SNARE Binding Organelle Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling SNAP Receptor Activity Calcium-dependent Protein Binding Secretion By Cell Secretion SNARE Complex Vesicle-mediated Transport In Synapse Membrane Fusion Vesicle Fusion Regulation Of Cell Communication Regulation Of Signaling Organelle Membrane Fusion Synapse Regulation Of Regulated Secretory Pathway Exocytosis Vesicle-mediated Transport Organelle Fusion Chemical Synaptic Transmission Glutamatergic Synapse Positive Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Trans-synaptic Signaling Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Neurotransmitter Secretion Regulation Of Protein Localization Synaptic Signaling Regulation Of Biological Quality Synaptic Vesicle Docking Signal Release Establishment Of Localization In Cell Calcium Channel Regulator Activity Positive Regulation Of Immune Response Regulation Of Synaptic Vesicle Exocytosis Regulation Of Exocytosis Somatodendritic Compartment Regulation Of Vesicle-mediated Transport Activation Of Immune Response Long-term Synaptic Potentiation Regulation Of Secretion By Cell Regulation Of Membrane Potential Cell-cell Signaling Presynaptic Membrane	Vesicle-mediated Transport In Synapse Clathrin-coated Pit Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle-mediated Transport Clathrin-coated Endocytic Vesicle Membrane Postsynaptic Neurotransmitter Receptor Internalization Clathrin Coat Of Coated Pit Chromaffin Granule Membrane Postsynaptic Endocytic Zone AP-2 Adaptor Complex Calcium-dependent Activation Of Synaptic Vesicle Fusion Synapse Dense Core Granule Endocytosis Calcium Ion Sensor Activity Positive Regulation Of Dendrite Extension Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Receptor-mediated Endocytosis Low-density Lipoprotein Particle Receptor Binding Exocytic Vesicle Regulation Of Vesicle-mediated Transport Glutamatergic Synapse Clathrin-dependent Endocytosis Calcium Ion Binding Import Into Cell Protein-macromolecule Adaptor Activity Regulation Of Vesicle Fusion Regulation Of Calcium Ion-dependent Exocytosis Endosomal Transport Regulation Of Synaptic Vesicle Exocytosis Calcium-dependent Phospholipid Binding Establishment Of Localization In Cell Vesicle Organization Positive Regulation Of Transport Cytoplasmic Vesicle SNARE Binding Receptor Internalization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Endocytic Vesicle Membrane Plasma Membrane Regulation Of Neurotransmitter Secretion Clathrin-dependent Synaptic Vesicle Endocytosis Syntaxin-3 Binding Positive Regulation Of Cellular Component Organization Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?