SYT1 and CACNB3

Number of citations of the paper that reports this interaction (PMID 16525042)
13

Data Source:
HPRD (two hybrid)

		SYT1	CACNB3
Gene Name		synaptotagmin I	calcium channel, voltage-dependent, beta 3 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule SNARE Complex Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane	Cytosol Voltage-gated Calcium Channel Complex Membrane Apical Plasma Membrane
	Molecular Function	SNARE Binding Phosphatidylserine Binding Transporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Syntaxin-1 Binding Clathrin Binding Identical Protein Binding Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding	Voltage-gated Calcium Channel Activity High Voltage-gated Calcium Channel Activity Protein Kinase Binding
	Biological Process	Detection Of Calcium Ion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Glutamate Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Positive Regulation Of Synaptic Transmission Protein Homooligomerization Regulation Of Synaptic Transmission, Glutamatergic Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway	Transport Calcium Ion Transport Synaptic Transmission Axon Guidance Neuromuscular Junction Development T Cell Receptor Signaling Pathway Membrane Depolarization Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Dopamine Neurotransmitter Release Cycle Toxicity of botulinum toxin type G (BoNT/G) Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses Adrenaline,noradrenaline inhibits insulin secretion
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		30 interactors: CACNA1A CACNB3 CACNB4 CALM1 FGF1 GNB2L1 GOLM1 IKBKG IRF3 NEDD4 NR1H3 NR3C1 NRXN1 PPARG RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A ZDHHC17	4 interactors: CACNA1B CACNA1C FASLG SYT1
Entrez ID		6857	784
HPRD ID		01710	11879
Ensembl ID		ENSG00000067715	ENSG00000167535
Uniprot IDs		J3KQA0 P21579	P54284
PDB IDs		2K45 2K4A 2K8M 2KI6 2LHA 2R83 3F00 3F01 3F04 3F05 4ISQ
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Neurotransmitter Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Vesicle Localization Regulation Of Cellular Localization Exocytosis Regulation Of Signaling Organelle Localization Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Signaling Establishment Of Vesicle Localization Regulation Of Cellular Component Organization Cell Communication Establishment Of Localization In Cell Intracellular Receptor Signaling Pathway Cellular Localization Establishment Of Organelle Localization Vesicle Fusion Vesicle-mediated Transport Membrane Depolarization Membrane Fusion Acid Secretion Regulation Of Vesicle-mediated Transport Protein Localization Regulation Of Protein Localization Regulation Of Membrane Potential Organelle Fusion Regulation Of Secretion Glucocorticoid Receptor Signaling Pathway Regulation Of Immune Response Vesicle Docking Transport Regulation Of Synaptic Transmission Establishment Of Protein Localization Membrane Docking Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Calcium Ion-dependent Exocytosis Regulation Of Protein Secretion Regulation Of Cellular Process Cell Differentiation Protein Transport Regulation Of Protein Localization To Plasma Membrane Membrane Organization	Cell-cell Signaling Calcium Ion Import Membrane Depolarization During Action Potential Secretion By Cell Synaptic Transmission Secretion Action Potential Neurotransmitter Secretion Membrane Depolarization Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Neurotransmitter Levels Neurotransmitter Transport Regulation Of Heart Contraction Regulation Of Blood Pressure Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport Smooth Muscle Contraction Involved In Micturition Calcium-mediated Signaling Using Extracellular Calcium Source Endosomal Lumen Acidification Locomotory Behavior Retinal Cell Programmed Cell Death Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Membrane Potential Necroptotic Signaling Pathway Calcium Ion Transport Blood Circulation Micturition Exocytosis Cellular Chloride Ion Homeostasis Inflammatory Cell Apoptotic Process Chloride Ion Homeostasis Ion Transport Urinary Bladder Smooth Muscle Contraction Regulation Of Ion Transmembrane Transport Positive Regulation Of Endothelial Cell Apoptotic Process Growth Hormone Secretion Detection Of Calcium Ion Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Cation Homeostasis Cellular Ion Homeostasis Establishment Of Localization In Cell Positive Regulation Of Calcium Ion-dependent Exocytosis Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion T Cell Apoptotic Process Cellular Chemical Homeostasis Positive Regulation Of Vesicle Fusion Signaling Ion Homeostasis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes	acinus adapter alg2 casp3 coinduction competing elucidating ercc3 fem1 gadd153 gadd34 gated gsn helps hereditary heretofore igf1 igfbp2 ischemia modules muscular nrp1 oligodeoxynucleotide permits smn1 tfdp1 tiar vim
Tagcloud (Difference) ?		carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes	acinus adapter alg2 casp3 coinduction competing elucidating ercc3 fem1 gadd153 gadd34 gated gsn helps hereditary heretofore igf1 igfbp2 ischemia modules muscular nrp1 oligodeoxynucleotide permits smn1 tfdp1 tiar vim
Tagcloud (Intersection) ?