SYT1 and MIP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYT1	MIP
Description		synaptotagmin 1	major intrinsic protein of lens fiber
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Synaptic Vesicle Postsynaptic Density Membrane Secretory Granule Axon Transport Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Neuron Projection Terminus Synapse Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Plasma Membrane Membrane Apical Plasma Membrane Anchoring Junction
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Syntaxin-1 Binding Syntaxin Binding Clathrin Binding Syntaxin-3 Binding Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding Calcium Ion Sensor Activity Molecular Condensate Scaffold Activity	Structural Constituent Of Eye Lens Protein Binding Calmodulin Binding Water Channel Activity Channel Activity Cell Adhesion Mediator Activity
	Biological Process	Detection Of Calcium Ion Vesicle Fusion Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Dopamine Secretion Vesicle Organization Synaptic Vesicle Exocytosis Vesicle-mediated Transport Regulation Of Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Regulation Of Vesicle Fusion Positive Regulation Of Vesicle Fusion Positive Regulation Of Dopamine Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Protein Heterooligomerization Response To Calcium Ion Regulation Of Synaptic Transmission, Glutamatergic Spontaneous Neurotransmitter Secretion Cellular Response To Calcium Ion Synchronous Neurotransmitter Secretion Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium-dependent Activation Of Synaptic Vesicle Fusion Membraneless Organelle Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis	Lens Development In Camera-type Eye Water Transport Visual Perception Homotypic Cell-cell Adhesion Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type G (botG) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation	Passive transport by Aquaporins
Drugs			B-nonylglucoside
Diseases
GWAS		Adiponectin levels ( 33562295) Brain morphology (MOSTest) ( 32665545) Chloride levels ( 29403010) Estimated glomerular filtration rate ( 31217584) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Hand grip strength ( 29313844) Intelligence (MTAG) ( 29326435) Lung function ( 31902109) Lysophosphatidylcholine levels ( 31551469) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) QRS duration ( 31251759) Sodium levels ( 29403010) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653)	Axial length ( 24144296) Lipoprotein (a) levels ( 33730874) Serum metabolite levels ( 33031748)
Interacting Genes		46 interacting genes: BNIP2 BTN2A2 CACNA1A CACNB3 CACNB4 CALM1 CREBBP CSGALNACT2 CYB5B DANCR FGF1 GIMAP5 GOLM1 HMOX2 IKBKG IRF3 MIP NAPB NEDD4 NR1H3 NR3C1 NRXN1 PPARG RACK1 RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A TMEM14C TMEM254 TMEM60 TSHR UBIAD1 ZDHHC17 ZFPL1	48 interacting genes: AQP6 AQP9 ATP6V0B CALM1 CD40 CISD2 CLDN5 CRYAA CRYAB CRYBB2 CRYGC ERGIC3 ERVFRD-1 FAM209A FCGR2A FOXA2 GJA3 GJA8 GJB5 GOLM1 GPX8 KCNJ6 LHFPL5 LMNA LRRC4C MFF MGST3 MRM3 MRPS18B MUC1 PDZK1IP1 PRKACA RELL2 SAR1A SGPL1 SLC14A1 SLC18A1 SSMEM1 STX1A STX2 SYAP1 SYT1 SYT2 TMEM139 TMEM154 TMEM52B TMX2 ZFPL1
Entrez ID		6857	4284
HPRD ID		01710	01098
Ensembl ID		ENSG00000067715	ENSG00000135517
Uniprot IDs		J3KQA0 P21579	P30301
PDB IDs		2K45 2K4A 2K8M 2KI6 2LHA 2N1T 2R83 3F00 3F01 3F04 3F05 4ISQ 4V11 6G5F 6G5K 6QNS 6TZ3 6U41 6U4U 6U4W 6ZVN 7TUA 7TX9 7U4Q 8B8I
Enriched GO Terms of Interacting Partners?		Neurotransmitter Transport Organelle Localization By Membrane Tethering Modulation Of Chemical Synaptic Transmission Membrane Docking Vesicle Docking SNARE Binding Organelle Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling SNAP Receptor Activity Calcium-dependent Protein Binding Secretion By Cell Secretion SNARE Complex Vesicle-mediated Transport In Synapse Membrane Fusion Vesicle Fusion Regulation Of Cell Communication Regulation Of Signaling Organelle Membrane Fusion Synapse Regulation Of Regulated Secretory Pathway Exocytosis Vesicle-mediated Transport Organelle Fusion Chemical Synaptic Transmission Glutamatergic Synapse Positive Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Trans-synaptic Signaling Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Neurotransmitter Secretion Regulation Of Protein Localization Synaptic Signaling Regulation Of Biological Quality Synaptic Vesicle Docking Signal Release Establishment Of Localization In Cell Calcium Channel Regulator Activity Positive Regulation Of Immune Response Regulation Of Synaptic Vesicle Exocytosis Regulation Of Exocytosis Somatodendritic Compartment Regulation Of Vesicle-mediated Transport Activation Of Immune Response Long-term Synaptic Potentiation Regulation Of Secretion By Cell Regulation Of Membrane Potential Cell-cell Signaling Presynaptic Membrane	Membrane Lens Development In Camera-type Eye Structural Constituent Of Eye Lens Structural Molecule Activity Urea Channel Activity Gap Junction Channel Activity Connexin Complex SNARE Binding Synaptic Vesicle Membrane One-carbon Compound Transport Water Transport Gap Junction Calcium-dependent Protein Binding Organelle Localization By Membrane Tethering Clathrin-sculpted Monoamine Transport Vesicle Membrane Urea Transmembrane Transporter Activity Membrane Docking Camera-type Eye Development Gap Junction-mediated Intercellular Transport Fluid Transport Plasma Membrane Protein Binding Regulation Of Calcium Ion-dependent Exocytosis Chromaffin Granule Membrane Urea Transmembrane Transport Tubulin Complex Assembly Intercellular Transport Amine Transport Urea Transport Modulation Of Chemical Synaptic Transmission Eye Development Positive Regulation Of Catecholamine Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion Water Channel Activity Calcium Channel Inhibitor Activity Vesicle Docking Detection Of Calcium Ion Positive Regulation Of Calcium Ion-dependent Exocytosis Dense Core Granule Calcium Ion Sensor Activity Voltage-gated Potassium Channel Complex Sensory Organ Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Dendrite Extension Positive Regulation Of Vesicle Fusion Glutathione Peroxidase Activity
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