MID1 and UBE2L3

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		MID1	UBE2L3
Gene Name		midline 1	ubiquitin-conjugating enzyme E2L 3
Image
Gene Ontology Annotations	Cellular Component	Spindle Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule	Ubiquitin Ligase Complex Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Microtubule Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Phosphoprotein Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Metabolic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Interferon-gamma-mediated Signaling Pathway	Protein Polyubiquitination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) HDL cholesterol ( 20686565) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517) Systemic lupus erythematosus ( 23273568 21408207 19838193)
Protein-Protein Interactions		30 interactors: BYSL DYRK4 EHHADH FKBP1A GMCL1 HTT IGBP1 MEOX1 MID1IP1 MID2 OTUB2 PKN1 PPP2CA PPP2CB PPP2R4 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1	64 interactors: ARIH1 ARIH2 ATXN3 BRCA1 CBL CBLC CCNB1IP1 CUL9 DTX3 FBXO2 FOS HACE1 HERC3 HSPA4 HUWE1 ITCH LIG4 MAPK6 MDM2 MID1 MKRN3 MUL1 NEDD4 NEDD4L NFKBIA NR3C1 PARK2 PJA1 POLR2A PTEN RAD23A RBCK1 RBX1 RELA RNF103 RNF113B RNF125 RNF144A RNF144B RNF19A RNF2 RNF216 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TRAF6 TRAF7 TRIM21 TRIM28 TRIM39 TRIP12 UBA1 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR5 WWP1 WWP2
Entrez ID		4281	7332
HPRD ID		02047	04762
Ensembl ID		ENSG00000101871	ENSG00000185651
Uniprot IDs		O15344	P68036
PDB IDs		2DQ5 2FFW 2JUN	1C4Z 1FBV 3SQV 3SY2
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Cellular Protein Modification Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Protein K63-linked Ubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Cellular Metabolic Process Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Proteasomal Protein Catabolic Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Innate Immune Response Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Cellular Response To Stress Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Innate Immune Response Regulation Of Dephosphorylation Protein Monoubiquitination Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Dephosphorylation ISG15-protein Conjugation Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Gene Expression Cellular Response To Organic Substance Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Polyubiquitination Proteolysis Protein Metabolic Process Catabolic Process Cellular Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Viral Process Regulation Of Protein Catabolic Process Cellular Response To Organic Substance Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Protein K48-linked Ubiquitination Negative Regulation Of Signaling Protein Monoubiquitination Cellular Response To Stress Metabolic Process Protein Autoubiquitination Response To Stress Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cellular Response To Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Organic Substance Response To Growth Factor Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cytokine Production Response To Transforming Growth Factor Beta Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair Positive Regulation Of Protein Catabolic Process
Tagcloud ?		adds alleviated amount biosynthesis butyrate depleted droplet dtt encodes ergosterol glycoproteins glycosylation homeostasis kloch1 kluyveromyces lactis ld lds lipid mannosyltrasferase misfolding mobilization och1 och1p outer pba phenyl reinforce remarkably	2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants
Tagcloud (Difference) ?		adds alleviated amount biosynthesis butyrate depleted droplet dtt encodes ergosterol glycoproteins glycosylation homeostasis kloch1 kluyveromyces lactis ld lds lipid mannosyltrasferase misfolding mobilization och1 och1p outer pba phenyl reinforce remarkably	2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants
Tagcloud (Intersection) ?