MID1 and IGBP1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		MID1	IGBP1
Description		midline 1	immunoglobulin binding protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Centriolar Satellite	Cytoplasm Cytosol
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Phosphoprotein Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Intracellular Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Regulation Of Dephosphorylation Intracellular Signal Transduction B Cell Activation Regulation Of Microtubule-based Movement Response To Interleukin-1
Pathways		Interferon gamma signaling
Drugs
Diseases		Opitz-GBBB syndrome	Corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia
GWAS
Interacting Genes		46 interacting genes: BYSL CDC37 CRY2 DYRK4 EHHADH ELOA EPN2 FAM50B FKBP1A GMCL1 HMG20B HTT IGBP1 KIF9 MEOX1 MID1IP1 MID2 N4BP1 OTUB2 PAX6 PDE4B PKN1 PPM1A PPP2CA PPP2CB PTCD2 PTPA RIC8A SPAG5 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UBTD1 ZNF618	12 interacting genes: APP HSPB1 LINC01257 MID1 MID2 PPP2CA PPP4C PPP6C PYGM REXO5 S100A13 SHOX
Entrez ID		4281	3476
HPRD ID		02047	02140
Ensembl ID		ENSG00000101871	ENSG00000089289
Uniprot IDs		A0A087X255 A0A8I5KPE0 A0A8I5KR14 O15344	P78318
PDB IDs		2DQ5 2FFW 2JUN 5IM8 7QRY	4IYP
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Monoubiquitination ISG15 Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding ISG15-protein Conjugation Nucleus Nucleotide Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Macromolecule Metabolic Process Transferase Activity Protein Phosphatase Type 2A Complex Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding UBC13-MMS2 Complex Regulation Of Metabolic Process Regulation Of Gene Expression Phosphoprotein Phosphatase Activity Cytosol Ubiquitin Conjugating Enzyme Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Proteolysis Negative Regulation Of Signal Transduction Regulation Of Protein Polyubiquitination Regulation Of Microtubule-based Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Ubiquitin Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Ligase Complex	Positive Regulation Of Interleukin-1 Production RAGE Receptor Binding Protein Serine/threonine Phosphatase Activity Protein Localization To Microtubule Response To Lead Ion Regulation Of Interleukin-1 Production Protein Homodimerization Activity Phosphoprotein Phosphatase Activity Regulation Of Intracellular Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Protein Localization To Cytoskeleton Phosphoprotein Binding RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Positive Regulation Of Interleukin-1 Beta Production Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Supramolecular Fiber Organization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Extracellular Exosome Regulation Of Interleukin-1 Beta Production Protein Kinase C Inhibitor Activity Regulation Of Canonical NF-kappaB Signal Transduction Cytoskeleton Protein Dephosphorylation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Glycogen Phosphorylase Activity Regulation Of Microtubule Polymerization Or Depolymerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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