MID1 and FKBP1A

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MID1	FKBP1A
Gene Name		midline 1	FK506 binding protein 1A, 12kDa
Image
Gene Ontology Annotations	Cellular Component	Spindle Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Terminal Cisterna Membrane Z Disc Sarcoplasmic Reticulum Membrane Axon Terminus Extracellular Vesicular Exosome
	Molecular Function	Microtubule Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Phosphoprotein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Signal Transducer Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Macrolide Binding FK506 Binding Calcium Channel Inhibitor Activity Enzyme Binding Hsp70 Protein Binding Type I Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Ion Channel Binding SMAD Binding Activin Binding
	Biological Process	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Metabolic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Interferon-gamma-mediated Signaling Pathway	Protein Peptidyl-prolyl Isomerization Negative Regulation Of Protein Phosphorylation Heart Morphogenesis Protein Folding 'de Novo' Protein Folding Muscle Contraction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Response To Iron Ion Cytokine-mediated Signaling Pathway Protein Maturation By Protein Folding Response To Caffeine Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Negative Regulation Of Protein Phosphatase Type 2B Activity Regulation Of Protein Localization Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Proliferation T Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Extracellular Fibril Organization Regulation Of Immune Response Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Heart Trabecula Formation Chaperone-mediated Protein Folding Calcium Ion Transmembrane Transport Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs			Pimecrolimus Tacrolimus Sirolimus (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl-Beta-D-Glucopyranoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-Hydroxy-2-Butanone MYRISTIC ACID (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS
Protein-Protein Interactions		30 interactors: BYSL DYRK4 EHHADH FKBP1A GMCL1 HTT IGBP1 MEOX1 MID1IP1 MID2 OTUB2 PKN1 PPP2CA PPP2CB PPP2R4 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1	21 interactors: ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A DHFR FKBP4 GLMN ITPR1 MID1 MTOR PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1
Entrez ID		4281	2280
HPRD ID		02047	01741
Ensembl ID		ENSG00000101871	ENSG00000088832
Uniprot IDs		O15344	P62942 Q0VDC6
PDB IDs		2DQ5 2FFW 2JUN	1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Cellular Protein Modification Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Protein K63-linked Ubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Cellular Metabolic Process Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Proteasomal Protein Catabolic Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Innate Immune Response Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Cellular Response To Stress Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Innate Immune Response Regulation Of Dephosphorylation Protein Monoubiquitination Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Dephosphorylation ISG15-protein Conjugation Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Gene Expression Cellular Response To Organic Substance Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Response To Organic Substance Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Transport Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Multicellular Organismal Development Regulation Of Phosphorylation Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Transport Response To Stress Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Response To Abiotic Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Protein Localization Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Phosphorylation Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Regulation Of Protein Localization To Nucleus Cell Differentiation Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Response To Organic Substance Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Intracellular Transport Response To Stimulus Negative Regulation Of Cell Differentiation Activin Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Differentiation Signal Transduction By Phosphorylation Regulation Of Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Chemical Homeostasis
Tagcloud ?		adds alleviated amount biosynthesis butyrate depleted droplet dtt encodes ergosterol glycoproteins glycosylation homeostasis kloch1 kluyveromyces lactis ld lds lipid mannosyltrasferase misfolding mobilization och1 och1p outer pba phenyl reinforce remarkably
Tagcloud (Difference) ?		adds alleviated amount biosynthesis butyrate depleted droplet dtt encodes ergosterol glycoproteins glycosylation homeostasis kloch1 kluyveromyces lactis ld lds lipid mannosyltrasferase misfolding mobilization och1 och1p outer pba phenyl reinforce remarkably
Tagcloud (Intersection) ?