MID1 and STK36

Number of citations of the paper that reports this interaction (PMID 25278022)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		MID1	STK36
Gene Name		midline 1	serine/threonine kinase 36
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule	Nucleus Cytoplasm
	Molecular Function	Microtubule Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Phosphoprotein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding
	Biological Process	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Metabolic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Interferon-gamma-mediated Signaling Pathway	Epithelial Cilium Movement Protein Phosphorylation Positive Regulation Of Hh Target Transcription Factor Activity Brain Development Post-embryonic Development Cilium Assembly Positive Regulation Of Smoothened Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 22959728)
Protein-Protein Interactions		30 interactors: BYSL DYRK4 EHHADH FKBP1A GMCL1 HTT IGBP1 MEOX1 MID1IP1 MID2 OTUB2 PKN1 PPP2CA PPP2CB PPP2R4 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1	9 interactors: CDK5RAP2 CDK9 FRMPD4 GLI1 GLI2 GLI3 MAST2 MID1 SUFU
Entrez ID		4281	27148
HPRD ID		02047	09631
Ensembl ID		ENSG00000101871	ENSG00000163482
Uniprot IDs		O15344	Q9NRP7
PDB IDs		2DQ5 2FFW 2JUN
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Cellular Protein Modification Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Protein K63-linked Ubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Cellular Metabolic Process Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Proteasomal Protein Catabolic Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Innate Immune Response Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Cellular Response To Stress Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Innate Immune Response Regulation Of Dephosphorylation Protein Monoubiquitination Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Dephosphorylation ISG15-protein Conjugation Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Gene Expression Cellular Response To Organic Substance Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity	Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Spinal Cord Interneuron Specification Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Smoothened Signaling Pathway Ventral Spinal Cord Interneuron Differentiation Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Notochord Regression Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Spinal Cord Patterning Pattern Specification Process Spinal Cord Motor Neuron Differentiation Proximal/distal Pattern Formation Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Positive Regulation Of Neural Precursor Cell Proliferation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Digestive Tract Morphogenesis Neuron Fate Commitment Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Embryonic Organ Morphogenesis Hindgut Morphogenesis Notochord Morphogenesis Cell Fate Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Hindgut Development Regulation Of Neural Precursor Cell Proliferation Spinal Cord Development Regulation Of DNA Replication Tube Morphogenesis Central Nervous System Development Anatomical Structure Regression Digestive Tract Development Digestive System Development Embryonic Organ Development Notochord Development Neural Tube Development Positive Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Central Nervous System Neuron Differentiation Negative Regulation Of Smoothened Signaling Pathway Dorsal/ventral Neural Tube Patterning Tube Development Lung Development
Tagcloud ?		adds alleviated amount biosynthesis butyrate depleted droplet dtt encodes ergosterol glycoproteins glycosylation homeostasis kloch1 kluyveromyces lactis ld lds lipid mannosyltrasferase misfolding mobilization och1 och1p outer pba phenyl reinforce remarkably
Tagcloud (Difference) ?		adds alleviated amount biosynthesis butyrate depleted droplet dtt encodes ergosterol glycoproteins glycosylation homeostasis kloch1 kluyveromyces lactis ld lds lipid mannosyltrasferase misfolding mobilization och1 och1p outer pba phenyl reinforce remarkably
Tagcloud (Intersection) ?