MID1 and DYRK4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MID1	DYRK4
Description		midline 1	dual specificity tyrosine phosphorylation regulated kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Centriolar Satellite	Nucleus Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Phosphoprotein Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Intracellular Signal Transduction
Pathways		Interferon gamma signaling
Drugs
Diseases		Opitz-GBBB syndrome
GWAS			Allergic rhinitis ( 25085501)
Interacting Genes		46 interacting genes: BYSL CDC37 CRY2 DYRK4 EHHADH ELOA EPN2 FAM50B FKBP1A GMCL1 HMG20B HTT IGBP1 KIF9 MEOX1 MID1IP1 MID2 N4BP1 OTUB2 PAX6 PDE4B PKN1 PPM1A PPP2CA PPP2CB PTCD2 PTPA RIC8A SPAG5 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UBTD1 ZNF618	6 interacting genes: CUL3 DYRK2 FBXO25 MID1 NEDD4 PPP1CC
Entrez ID		4281	8798
HPRD ID		02047	10926
Ensembl ID		ENSG00000101871	ENSG00000010219
Uniprot IDs		A0A087X255 A0A8I5KPE0 A0A8I5KR14 O15344	A0A0A0MTH5 B4E1A4 D3JEN2 Q9NR20
PDB IDs		2DQ5 2FFW 2JUN 5IM8 7QRY
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Monoubiquitination ISG15 Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding ISG15-protein Conjugation Nucleus Nucleotide Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Macromolecule Metabolic Process Transferase Activity Protein Phosphatase Type 2A Complex Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding UBC13-MMS2 Complex Regulation Of Metabolic Process Regulation Of Gene Expression Phosphoprotein Phosphatase Activity Cytosol Ubiquitin Conjugating Enzyme Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Proteolysis Negative Regulation Of Signal Transduction Regulation Of Protein Polyubiquitination Regulation Of Microtubule-based Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Ubiquitin Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Ligase Complex	Ubiquitin Ligase Complex Protein Modification Process Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Activity Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Cytoskeleton Regulation Of Nucleocytoplasmic Transport Channel Inhibitor Activity Glutamatergic Synapse Protein Metabolic Process Trophectodermal Cellular Morphogenesis Liver Morphogenesis Protein Ubiquitination Phosphothreonine Residue Binding Regulation Protein Catabolic Process At Postsynapse Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Sodium Ion Transport Protein-containing Complex Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Intrinsic Apoptotic Signaling Pathway POZ Domain Binding Polar Microtubule Post-translational Protein Modification Phosphoserine Residue Binding Beta-2 Adrenergic Receptor Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Intracellular Signal Transduction Protein Domain Specific Binding PTW/PP1 Phosphatase Complex Nuclear Protein Quality Control By The Ubiquitin-proteasome System Spindle Sodium Channel Inhibitor Activity Postsynapse Ubiquitin Ligase Complex Scaffold Activity Embryonic Cleavage
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