MID1 and PTCD2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MID1	PTCD2
Name		midline 1	pentatricopeptide repeat domain 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Centriolar Satellite	Mitochondrion
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Phosphoprotein Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Intracellular Signal Transduction	Kidney Development Liver Development MRNA Processing Mitochondrion Organization Heart Development Regulation Of Gene Expression Regulation Of MRNA Processing Muscle Cell Development Ventricular Cardiac Muscle Tissue Morphogenesis
Pathways		Interferon gamma signaling	None
Diseases		Opitz-GBBB syndrome	None
GWAS		No GWAS studies recorded	Apolipoprotein A1 levels ( 32203549 ) Asthma ( 32296059 ) Asthma (childhood onset) ( 31036433 ) Glaucoma ( 31959993 ) Intraocular pressure ( 29617998 29785010 30054594 31959993 ) Pulse pressure ( 27841878 ) Refractive error ( 32231278 )
Interacting Genes		46 interacting genes: BYSL CDC37 CRY2 DYRK4 EHHADH ELOA EPN2 FAM50B FKBP1A GMCL1 HMG20B HTT IGBP1 KIF9 MEOX1 MID1IP1 MID2 N4BP1 OTUB2 PAX6 PDE4B PKN1 PPM1A PPP2CA PPP2CB PTCD2 PTPA RIC8A SPAG5 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UBTD1 ZNF618	4 interacting genes: MID1 MID2 TRIM32 USP49
Entrez ID		4281	79810
HPRD ID		02047	15193
Ensembl ID		ENSG00000101871	ENSG00000049883
Uniprot IDs		A0A087X255 A0A8I5KPE0 A0A8I5KR14 O15344	B3KPU6 B7Z8R2 F6S289 Q8WV60
PDB IDs		2DQ5 2FFW 2JUN 5IM8 7QRY	Not available
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Monoubiquitination ISG15 Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding ISG15-protein Conjugation Nucleus Nucleotide Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Macromolecule Metabolic Process Transferase Activity Protein Phosphatase Type 2A Complex Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding UBC13-MMS2 Complex Regulation Of Metabolic Process Regulation Of Gene Expression Phosphoprotein Phosphatase Activity Cytosol Ubiquitin Conjugating Enzyme Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Proteolysis Negative Regulation Of Signal Transduction Regulation Of Protein Polyubiquitination Regulation Of Microtubule-based Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Ubiquitin Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Ligase Complex	Protein Localization To Microtubule Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Viral Transcription Ubiquitin Protein Ligase Activity Phosphoprotein Binding Protein Localization To Cytoskeleton Negative Regulation Of Viral Process Protein Localization To Organelle Zinc Ion Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Regulation Of Viral Process Post-translational Protein Modification Protein Localization To Phagocytic Vesicle Positive Regulation Of Autophagy Striated Muscle Myosin Thick Filament Regulation Of Signal Transduction Actin Modification Histone H2B Deubiquitinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Microtubule Binding Cytosolic Ciliogenesis Regulation Of Cell Communication Regulation Of Signaling Transcription Coactivator Activity Defense Response To Virus Free Ubiquitin Chain Polymerization Metal Ion Binding Regulation Of Canonical NF-kappaB Signal Transduction Microtubule Tat Protein Binding Regulation Of Autophagy Enzyme Binding Positive Regulation Of Signal Transduction Protein Modification Process Response To Virus Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Transferase Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cell Communication Intracellular Protein Localization Positive Regulation Of Signaling Identical Protein Binding Translation Initiation Factor Binding Host-mediated Suppression Of Symbiont Invasion