MAEA and UBE2H

Number of citations of the paper that reports this interaction (PubMedID 38113892)
104

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, affinity chromatography technology)

		MAEA	UBE2H
Description		macrophage erythroblast attacher, E3 ubiquitin ligase	ubiquitin conjugating enzyme E2 H
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Nuclear Matrix GID Complex	Nucleus Cytosol
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Cytoskeleton Organization Cell Adhesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Myeloid Cell Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Erythrocyte Development Enucleate Erythrocyte Development Cell Division	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Regulation of pyruvate metabolism	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Tetrachlorodecaoxide
Diseases
GWAS		Fasting glucose ( 34059833) Obesity-related traits ( 23251661) Pulse pressure ( 30224653) Type 2 diabetes ( 22158537 23945395 26818947 28869590 30297969 30718926 32499647)	Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: GID4 GSK3A MYOC UBE2D3 UBE2H UBE2R2	71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		10296	7328
HPRD ID		08427	03052
Ensembl ID		ENSG00000090316	ENSG00000186591
Uniprot IDs		B3KRN7 B4DJP8 B4DQT1 B4DVN3 D6RIB6 Q7L5Y9	A0A3B3IU20 A4D1L5 P62256
PDB IDs		8PJN	2Z5D 8PJN
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Proteolysis Proteasomal Protein Catabolic Process Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Ubiquitin-protein Transferase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Protein Polyubiquitination Protein K11-linked Ubiquitination Catabolic Process Regulation Of Protein Targeting To Mitochondrion Protein Monoubiquitination Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of UDP-glucose Catabolic Process Skeletal Muscle Hypertrophy ATP Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Cell-substrate Adhesion Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Nucleotide Binding Regulation Of Glycogen (starch) Synthase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Clustering Of Voltage-gated Sodium Channels Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Cell-substrate Adhesion Cellular Response To Interleukin-3 Myosin Light Chain Binding Skeletal Muscle Adaptation Proximal Dendrite Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Mitochondrial Depolarization Wnt Signaling Pathway	Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism
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