CHRD and BMP2

Number of citations of the paper that reports this interaction (PMID 15064755)
34

Data Source:
HPRD (in vitro)

		CHRD	BMP2
Gene Name		chordin	bone morphogenetic protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	Protein Binding Heparin Binding Cytokine Binding Syndecan Binding	Retinol Dehydrogenase Activity Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Phosphatase Activator Activity SMAD Binding Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Gastrulation With Mouth Forming Second Mesoderm Formation Positive Regulation Of Mesenchymal Cell Proliferation BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Forebrain Development Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Skeletal System Development Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Chondrocyte Differentiation BMP Signaling Pathway Involved In Heart Induction Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Proteoglycan Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Negative Regulation Of Cell Proliferation Embryo Development Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Protein Destabilization Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Bone Mineralization Involved In Bone Maturation Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Mesenchyme Development Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Positive Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of P38MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways			Molecules associated with elastic fibres Elastic fibre formation Signaling by BMP
Drugs
Diseases
GWAS		Platelet counts ( 20139978)	Body mass index ( 19079261 23669352) Colorectal cancer ( 23266556) Height ( 20881960 23563607 18391951) Obesity-related traits ( 23251661) Refractive error ( 23396134) Sagittal craniosynostosis ( 23160099)
Protein-Protein Interactions		26 interactors: ATN1 BMP1 BMP2 CATSPER1 CD36 F2R HOXA1 HRG KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 MEOX2 NOTCH2NL NR0B2 OTX1 PLSCR1 SMAD3 SPRY2 TLL1 TWSG1	19 interactors: ACTR2 ACVR1 ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG SOSTDC1 TGFB1 TGFB2
Entrez ID		8646	650
HPRD ID		04592	00206
Ensembl ID		ENSG00000090539	ENSG00000125845
Uniprot IDs		E7ESX1 Q9H2X0	C8C060 P12643
PDB IDs			1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Gene Expression Anterior/posterior Pattern Specification Positive Regulation Of Blood Coagulation Regulation Of Wound Healing Anatomical Structure Morphogenesis Positive Regulation Of Coagulation Positive Regulation Of Cartilage Development Sensory Organ Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Wound Healing Organ Morphogenesis System Development Regulation Of Transcription, DNA-templated Positive Regulation Of Cell-matrix Adhesion Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Inner Ear Development Embryo Development Platelet Activation Pattern Specification Process Embryonic Organ Development Ear Development Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cartilage Development Positive Regulation Of Cellular Metabolic Process Skeletal System Development Regulation Of Blood Coagulation Ossification Positive Regulation Of Metabolic Process Inner Ear Morphogenesis Wound Healing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Embryonic Organ Morphogenesis Regulation Of Cell-matrix Adhesion Embryonic Morphogenesis Regulation Of Protein Phosphorylation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Osteoblast Proliferation Negative Regulation Of Cell Proliferation	Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification BMP Signaling Pathway Regulation Of BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Development Pattern Specification Process Tube Development Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Skeletal System Development Epithelium Development Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cartilage Development Regulation Of Signal Transduction Organ Morphogenesis Multicellular Organismal Development Organ Development Connective Tissue Development Anatomical Structure Development Regulation Of Signaling System Development Positive Regulation Of Bone Mineralization Cell Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Developmental Process Dorsal/ventral Pattern Formation Regulation Of Osteoblast Differentiation Embryonic Morphogenesis Tissue Morphogenesis Skeletal System Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cartilage Development Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Embryo Development Negative Regulation Of Signaling Regulation Of Cell Differentiation Sensory Organ Development Positive Regulation Of Signal Transduction Mesoderm Development Cell Development Signal Transduction By Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Phosphorylation Stem Cell Differentiation
Tagcloud ?		affymetrix axin2 bglap2 bmp bridge chrdl2 cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1	agonists antagonists apoptosis bmp4 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety
Tagcloud (Difference) ?		affymetrix axin2 bglap2 bridge chrdl2 cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1	agonists antagonists apoptosis bmp4 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety
Tagcloud (Intersection) ?		bmp