CHRD and BMP2

Number of citations of the paper that reports this interaction (PubMedID 15064755)
0

Data Source:
HPRD (in vitro)

		CHRD	BMP2
Description		chordin	bone morphogenetic protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Plasma Membrane Cilium Cell Surface BMP Receptor Complex Enzyme Activator Complex
	Molecular Function	Protein Binding Cytokine Binding BMP Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Phosphatase Activator Activity Co-receptor Binding Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity BMP Receptor Binding
	Biological Process	Skeletal System Development Positive Regulation Of Mesenchymal Cell Proliferation Pattern Specification Process Dorsal/ventral Pattern Formation Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion System Development	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Chondrocyte Differentiation Myeloid Leukocyte Differentiation Heart Morphogenesis Heart Induction Endodermal-mesodermal Cell Signaling Aortic Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Atrium Formation Endocardial Cushion Formation Positive Regulation Of Extracellular Matrix Constituent Secretion Proteoglycan Metabolic Process Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Bacterium Animal Organ Morphogenesis Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Negative Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Protein Destabilization Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Cell Proliferation Astrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Negative Regulation Of Muscle Cell Differentiation Cartilage Development Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Bone Development Positive Regulation Of SMAD Protein Signal Transduction Lung Vasculature Development Mesenchyme Development Muscle Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Odontoblast Differentiation Positive Regulation Of MiRNA Transcription Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cortisol Biosynthetic Process Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways			Signaling by BMP Molecules associated with elastic fibres Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet count ( 20139978 32888494) Plateletcrit ( 27863252 32888494)	Adult body size ( 32376654) Atrial fibrillation ( 29892015) Axial length ( 24144296) Body mass index ( 19079261 25673413 23669352 28892062) Body size at age 10 ( 32376654) Childhood ear infection ( 27182965) Colorectal cancer ( 23266556 29471430 24737748 30529582 31826910 25990418 26151821) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Height ( 31562340 25429064 25282103 23563607 18391951 20881960) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30804560 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Major depressive disorder (stressful life events interaction) ( 26845276) Mitochondrial heteroplasmy measurement ( 33731350) Nose morphology (partial least square model) ( 30174134) Obesity-related traits ( 23251661) Optic cup area ( 25631615 31798171 28073927) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QRS complex (Cornell) ( 27659466) Refractive error ( 23396134 32231278) Retinal detachment or retinal break ( 31816047) Sagittal craniosynostosis ( 23160099) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels x loop diuretics use interaction ( 31806883) Vertical cup-disc ratio ( 28073927 25241763 31798171) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		60 interacting genes: ADAMTSL4 ATN1 BMP1 BMP2 CATSPER1 CD36 CHRDL2 CYSRT1 F2R FXR1 FXR2 GATA1 HOXA1 HRG INCA1 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP19-2 KRTAP19-5 KRTAP22-1 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 LCE1C LCE1F LCE5A LIN7A MEOX2 NBPF19 NOTCH2NLA NR0B2 NR4A3 NUFIP2 OTX1 PLSCR1 POU4F2 RGS17 SLC15A2 SMAD3 SPRY1 SPRY2 SPRY3 TLL1 TRIM42 TSPAN4 TWSG1	21 interacting genes: ACTR2 ACVR1 ACVR2A ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG RGMB SOSTDC1 TGFB1 TGFB2
Entrez ID		8646	650
HPRD ID		04592	00206
Ensembl ID		ENSG00000090539	ENSG00000125845
Uniprot IDs		E7ESX1 Q8N2W7 Q9H2X0	C8C060 P12643
PDB IDs			1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP 4MID 4N1D 4UHY 4UHZ 4UI0 4UI1 4UI2 6OMN 7AG0 8E3G
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Epidermis Development Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Identical Protein Binding Positive Regulation Of Blood Coagulation Keratinization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Osteoblast Proliferation Pericardium Development Positive Regulation Of Coagulation Positive Regulation Of Cartilage Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Developmental Process Animal Organ Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of ERK1 And ERK2 Cascade Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesoderm Formation Regulation Of Ras Protein Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Transcription Coactivator Binding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Osteoblast Proliferation Branch Elongation Of An Epithelium Inner Ear Development Nuclear Glucocorticoid Receptor Binding Hair Cycle Ossification Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Inner Ear Morphogenesis Positive Regulation Of Cell-matrix Adhesion Formation Of Primary Germ Layer MAPK Cascade Epithelium Development Regulation Of Wound Healing Negative Regulation Of Small GTPase Mediated Signal Transduction	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway BMP Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Binding Regulation Of SMAD Protein Signal Transduction BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To BMP Stimulus Pattern Specification Process Regulation Of Ossification Response To Growth Factor Regulation Of Bone Mineralization Regulation Of Osteoblast Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Regulation Of BMP Signaling Pathway System Development Dorsal/ventral Pattern Formation Negative Regulation Of BMP Signaling Pathway Animal Organ Morphogenesis Tissue Development Positive Regulation Of Bone Mineralization Regulation Of Signal Transduction Embryonic Morphogenesis Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Animal Organ Development Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Differentiation Outflow Tract Septum Morphogenesis Regulation Of Signaling Regulation Of Cell Communication Activin Receptor Signaling Pathway Regulation Of Developmental Process Cardiac Septum Morphogenesis Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Positive Regulation Of Developmental Process Activin Binding Pharyngeal Arch Artery Morphogenesis Ventricular Septum Morphogenesis Activin Receptor Activity, Type II
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