CHRD and CATSPER1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CHRD	CATSPER1
Description		chordin	cation channel sperm associated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Cilium Membrane Motile Cilium Monoatomic Ion Channel Complex Sperm Flagellum CatSper Complex Cell Projection Sperm Principal Piece
	Molecular Function	Protein Binding Cytokine Binding BMP Binding	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding
	Biological Process	Skeletal System Development Positive Regulation Of Mesenchymal Cell Proliferation Pattern Specification Process Dorsal/ventral Pattern Formation Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion System Development	Monoatomic Ion Transport Calcium Ion Transport Spermatogenesis Cell Differentiation Flagellated Sperm Motility Monoatomic Ion Transmembrane Transport Transmembrane Transport Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Calcium Ion Transmembrane Transport
Pathways			Sperm Motility And Taxes
Drugs			Bisphenol A diglycidyl ether
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet count ( 20139978 32888494) Plateletcrit ( 27863252 32888494)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340)
Interacting Genes		60 interacting genes: ADAMTSL4 ATN1 BMP1 BMP2 CATSPER1 CD36 CHRDL2 CYSRT1 F2R FXR1 FXR2 GATA1 HOXA1 HRG INCA1 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP19-2 KRTAP19-5 KRTAP22-1 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 LCE1C LCE1F LCE5A LIN7A MEOX2 NBPF19 NOTCH2NLA NR0B2 NR4A3 NUFIP2 OTX1 PLSCR1 POU4F2 RGS17 SLC15A2 SMAD3 SPRY1 SPRY2 SPRY3 TLL1 TRIM42 TSPAN4 TWSG1	119 interacting genes: ABLIM3 ADAMTSL4 AGR2 AGR3 AJUBA AKAP8L APOA2 ARID5A BEGAIN C11orf16 CARD10 CDPF1 CFAP68 CHIC2 CHRD CPSF7 CTBP2 CYSRT1 EFEMP2 EMD EYA2 FHL5 FRS3 FST GLI1 HNRNPH1 HOXA1 IKZF3 KHDRBS2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1D LCE1E LCE1F LCE2C LCE5A LIMS1 LZTS2 MDFI MTUS2 MYCL NBPF19 NOTCH2NLA PAK5 PDLIM7 PLA2G10 PLAGL2 PLSCR1 PLSCR3 PMF1-BGLAP PTPN21 RFX6 RGS19 RGS20 RIMBP3 RSPO2 SAXO4 SCRG1 SIVA1 SORBS3 SPMIP6 SPRY2 SPRY3 SSC4D TGFB1 TNS2 TRAF2 TRIM27 TRIM42 TRIM8 TRIP6 TSPAN4 VWC2 ZBTB42 ZIM2 ZNF688 ZNF774 ZNF837
Entrez ID		8646	117144
HPRD ID		04592	09396
Ensembl ID		ENSG00000090539	ENSG00000175294
Uniprot IDs		E7ESX1 Q8N2W7 Q9H2X0	Q8NEC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Epidermis Development Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Identical Protein Binding Positive Regulation Of Blood Coagulation Keratinization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Osteoblast Proliferation Pericardium Development Positive Regulation Of Coagulation Positive Regulation Of Cartilage Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Developmental Process Animal Organ Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of ERK1 And ERK2 Cascade Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesoderm Formation Regulation Of Ras Protein Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Transcription Coactivator Binding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Osteoblast Proliferation Branch Elongation Of An Epithelium Inner Ear Development Nuclear Glucocorticoid Receptor Binding Hair Cycle Ossification Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Inner Ear Morphogenesis Positive Regulation Of Cell-matrix Adhesion Formation Of Primary Germ Layer MAPK Cascade Epithelium Development Regulation Of Wound Healing Negative Regulation Of Small GTPase Mediated Signal Transduction	Intermediate Filament Keratin Filament Keratinization Epidermis Development Identical Protein Binding Hair Cycle Protein Binding Cytosol Lead Ion Binding Lung Growth Mercury Ion Binding
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