CHRD and HRG

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CHRD	HRG
Description		chordin	histidine rich glycoprotein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Cytokine Binding BMP Binding	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding Immunoglobulin Binding Heme Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding
	Biological Process	Skeletal System Development Positive Regulation Of Mesenchymal Cell Proliferation Pattern Specification Process Dorsal/ventral Pattern Formation Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion System Development	Angiogenesis Positive Regulation Of Immune Response To Tumor Cell Chemotaxis Negative Regulation Of Cell Adhesion Blood Coagulation Hemostasis Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Regulation Of Platelet Activation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Angiogenesis Platelet Activation Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Adhesion Mediated By Integrin Fibrinolysis Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Fungus Cytolysis By Host Of Symbiont Cells Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Fibrinolysis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Endothelial Cell Chemotaxis
Pathways			Platelet degranulation Dissolution of Fibrin Clot
Drugs			Zinc chloride Zinc sulfate, unspecified form
Diseases			Inherited thrombophilia
GWAS		Diisocyanate-induced asthma ( 25918132) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet count ( 20139978 32888494) Plateletcrit ( 27863252 32888494)	Activated partial thromboplastin time ( 20303064 22703881) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neurological blood protein biomarker levels ( 31320639) Refractive error ( 32231278)
Interacting Genes		60 interacting genes: ADAMTSL4 ATN1 BMP1 BMP2 CATSPER1 CD36 CHRDL2 CYSRT1 F2R FXR1 FXR2 GATA1 HOXA1 HRG INCA1 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP19-2 KRTAP19-5 KRTAP22-1 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 LCE1C LCE1F LCE5A LIN7A MEOX2 NBPF19 NOTCH2NLA NR0B2 NR4A3 NUFIP2 OTX1 PLSCR1 POU4F2 RGS17 SLC15A2 SMAD3 SPRY1 SPRY2 SPRY3 TLL1 TRIM42 TSPAN4 TWSG1	15 interacting genes: C1QA C1QB CHRD CYSRT1 FCGR1A FGA FN1 PLG PLSCR1 RABAC1 RCHY1 RGS20 SPRY1 THBS1 TNFRSF1A
Entrez ID		8646	3273
HPRD ID		04592	00812
Ensembl ID		ENSG00000090539	ENSG00000113905
Uniprot IDs		E7ESX1 Q8N2W7 Q9H2X0	P04196
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Epidermis Development Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Identical Protein Binding Positive Regulation Of Blood Coagulation Keratinization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Osteoblast Proliferation Pericardium Development Positive Regulation Of Coagulation Positive Regulation Of Cartilage Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Developmental Process Animal Organ Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of ERK1 And ERK2 Cascade Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesoderm Formation Regulation Of Ras Protein Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Transcription Coactivator Binding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Osteoblast Proliferation Branch Elongation Of An Epithelium Inner Ear Development Nuclear Glucocorticoid Receptor Binding Hair Cycle Ossification Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Inner Ear Morphogenesis Positive Regulation Of Cell-matrix Adhesion Formation Of Primary Germ Layer MAPK Cascade Epithelium Development Regulation Of Wound Healing Negative Regulation Of Small GTPase Mediated Signal Transduction	Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex IgG Binding Platelet Alpha Granule Lumen Protein Activation Cascade Extracellular Matrix Complement Component C1q Complex Blood Microparticle Biological Process Involved In Interaction With Symbiont Defense Response IgM Binding Complement Component C1 Complex Cell Surface Phosphatidylserine Binding Acute Inflammatory Response Synapse Pruning Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Cell-substrate Adhesion Negative Regulation Of Fibrinolysis Proteoglycan Binding Inflammatory Response Regulation Of Fibrinolysis Protease Binding Symbiont Cell Surface Platelet Alpha Granule Fibrinolysis Extracellular Matrix Structural Constituent Protein Maturation Extracellular Region Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus External Side Of Plasma Membrane Negative Regulation Of Protein Maturation Response To Other Organism Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Phagocytosis, Engulfment Positive Regulation Of Coagulation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Response To Stress Complement Activation, Classical Pathway Regulation Of Cell Adhesion Regulation Of Response To Wounding Response To External Biotic Stimulus Acute-phase Response Membrane Invagination High-affinity IgG Receptor Activity Regulation Of Cell Communication
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?