STX6 and EEA1

Number of citations of the paper that reports this interaction (PMID 10506127)
44

Data Source:
HPRD (in vitro)

		STX6	EEA1
Gene Name		syntaxin 6	early endosome antigen 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle SNARE Complex Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Cytoplasmic Vesicle Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin Binding	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Vesicle Fusion Endosome Organization Regulation Of Protein Localization Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Golgi Ribbon Formation	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Early Endosome To Late Endosome Transport
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs			Inositol 1,3-Bisphosphate
Diseases
GWAS		Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		15 interactors: EEA1 GOPC GOSR2 MARCH2 NAPB PSMA3 PTPN9 SNAP23 SNAP29 STX16 STX4 STX7 VAMP4 VPS11 VPS18	11 interactors: IGF1R MAPK14 RAB22A RAB5A RAB5B RAB5C STX12 STX6 TOM1 USO1 ZFYVE16
Entrez ID		10228	8411
HPRD ID		07231	05460
Ensembl ID		ENSG00000135823	ENSG00000102189
Uniprot IDs		B4DR17 O43752	Q15075
PDB IDs		2NPS	1HYI 1HYJ 1JOC 3MJH
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle-mediated Transport Vesicle Organization Establishment Of Localization In Cell Membrane Organization Cellular Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Membrane Transport Vesicle Docking Post-Golgi Vesicle-mediated Transport Membrane Docking Golgi Vesicle Transport Cellular Protein Localization Synaptic Vesicle Transport Intracellular Protein Transport Exocytosis Regulation Of Establishment Of Protein Localization To Plasma Membrane Organelle Organization Organelle Localization Synaptic Vesicle Exocytosis Establishment Of Vesicle Localization Golgi Ribbon Formation Vesicle Localization Secretion By Cell Regulation Of Golgi To Plasma Membrane Protein Transport Synaptic Vesicle Priming SNARE Complex Assembly Secretion Neurotransmitter Secretion Establishment Of Organelle Localization Cellular Protein Complex Assembly Regulation Of Vesicle-mediated Transport Regulation Of Neurotransmitter Levels Neurotransmitter Transport Endosomal Transport Protein Complex Assembly Vesicle Targeting Synaptic Transmission Intra-Golgi Vesicle-mediated Transport Cellular Macromolecular Complex Assembly Cellular Component Assembly Synaptic Vesicle To Endosome Fusion Cytoplasmic Sequestering Of CFTR Protein	Intracellular Protein Transport Endosomal Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Rab Protein Signal Transduction Vesicle-mediated Transport Ras Protein Signal Transduction Cellular Localization Endosome Organization Regulation Of Endocytosis Vesicle Fusion Vesicle Organization Plasma Membrane To Endosome Transport Small GTPase Mediated Signal Transduction Organelle Fusion Cytoplasmic Transport Regulation Of Vesicle-mediated Transport Membrane Fusion Transport Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization P38MAPK Cascade Inactivation Of MAPKK Activity Vesicle Docking Membrane Docking Endomembrane System Organization Regulation Of Vesicle Size Golgi Vesicle Docking Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Brown Fat Cell Differentiation Endocytosis Golgi Ribbon Formation Signal Transduction Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Vesicle Fusion With Golgi Apparatus Positive Regulation Of Hormone Biosynthetic Process 3'-UTR-mediated MRNA Stabilization Stress-induced Premature Senescence Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Targeting To Lysosome
Tagcloud ?		alpha5beta1 alphavbeta3 boundaries c1 cho cholesterol endosome endosomes export hamster imbalance integrins interferes niemann npc1 ovary pick rab11 re recycling res restoration restores snare syntaxin tgn transferrin tuning vamp3	appl1 characterised colocalisation colocalises compartments employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst
Tagcloud (Difference) ?		alpha5beta1 alphavbeta3 boundaries c1 cho cholesterol export hamster imbalance integrins interferes niemann npc1 ovary pick rab11 re recycling res restoration restores snare syntaxin tgn transferrin tuning vamp3	appl1 characterised colocalisation colocalises compartments employ endocytic engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst
Tagcloud (Intersection) ?		endosome endosomes