STX6 and TMEM86B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STX6	TMEM86B
Description		syntaxin 6	transmembrane protein 86B
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Clathrin-coated Vesicle Synaptic Vesicle Membrane Organelle Membrane SNARE Complex Vesicle Trans-Golgi Network Membrane Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding	Protein Binding Hydrolase Activity Ether Hydrolase Activity Identical Protein Binding Alkenylglycerophosphocholine Hydrolase Activity D-lysine 5,6-aminomutase Activity
	Biological Process	Intracellular Protein Transport Vesicle Fusion Endosome Organization Protein Transport Synaptic Vesicle To Endosome Fusion Vesicle-mediated Transport Endocytic Recycling Regulation Of Protein Localization Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Vesicle Docking	Lipid Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Ether Lipid Metabolic Process
Pathways		Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Acyl chain remodelling of PC
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Creutzfeldt-Jakob disease (sporadic) ( 32949544) Intralaminar thalamic nuclei volume ( 34006833) Menopause (age at onset) ( 26414677) Progressive supranuclear palsy ( 21685912 30089514) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Mean reticulocyte volume ( 32888494) Phosphatidylethanolamine-ether levels ( 31551469) Serum metabolite levels ( 33031748) Systemic lupus erythematosus ( 28714469 33536424)
Interacting Genes		33 interacting genes: AQP6 ARMC8 DNAJC5 EBP EEA1 FAM210B GOLM2 GOPC LIME1 LMNA MARCHF2 MEOX2 MMGT1 MTERF2 MTIF3 NAPB PSMA3 PTPN9 SCN3B SNAP23 SNAP29 STOM STX16 STX1A STX2 STX7 TIMMDC1 TMEM14B TMEM205 TMEM86B VAMP4 VPS11 VPS18	106 interacting genes: AQP6 ARL13B ARL6IP6 ASGR2 BCL2L13 BIK BMP10 C2CD2L CCDC167 CCDC34 CCL4 CD53 CD79A CLRN1 CYB5B DHRSX DNAJC30 EBP ERGIC3 ERP29 EVI2B F11R FAM209A FAXDC2 FFAR2 FKBP7 FXYD6 GJA1 GJA4 GJA8 GOLM1 GPR37L1 GPX8 GUCA2A HIBADH HSD17B13 IER3IP1 IFITM3 KIR2DL3 LAPTM4B LIME1 LSS LY6D MARCHF2 MFF MGST3 MMGT1 MS4A14 MSMO1 MUC1 NDUFAF1 NEMP1 NINJ2 ORMDL2 OTULINL PEX11G PGRMC2 PIGF PLN PSCA PTPN1 PTPN9 RHBDD1 RHOT2 RPRM RTP2 SEC22B SERINC2 SFRP1 SFT2D1 SFXN5 SLC10A6 SLC29A2 SLC35G2 SLC39A9 SMIM1 SNORC SSMEM1 STOM STX12 STX6 STX8 TEX29 THAP4 THBD TIMM23 TMEM106A TMEM107 TMEM120A TMEM14A TMEM14C TMEM203 TMEM237 TMEM248 TMEM52B TMEM60 TMPRSS2 TMX2 TREX1 TSNARE1 USE1 VAMP2 VAMP3 VAMP5 VAPA ZDHHC22
Entrez ID		10228	255043
HPRD ID		07231	14540
Ensembl ID		ENSG00000135823	ENSG00000180089
Uniprot IDs		O43752	Q8N661
PDB IDs		2NPS 4J2C
Enriched GO Terms of Interacting Partners?		Organelle Fusion Vesicle Fusion Organelle Membrane Fusion SNARE Complex Syntaxin Binding Membrane Fusion SNAP Receptor Activity Organelle Localization By Membrane Tethering Vesicle Organization Membrane Docking Vesicle Docking Vesicle-mediated Transport Membrane Organization Cytoplasmic Vesicle Establishment Of Protein Localization Protein Transport Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Organelle Localization Cellular Localization Establishment Of Localization In Cell Synaptic Vesicle Membrane Organization Membrane SNARE Binding Intracellular Transport Synaptic Vesicle To Endosome Fusion Intracellular Protein Localization Endosome Organization Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Exocytosis Localization Within Membrane Vesicle Docking Involved In Exocytosis Lysosomal Membrane ATP-dependent Protein Binding Chloride Channel Inhibitor Activity CORVET Complex Azurophil Granule Membrane Endomembrane System Regulation Of Synaptic Vesicle Priming Azurophil Granule SNARE Complex Assembly Regulation Of Protein Localization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway HOPS Complex Endocytic Vesicle Early Endosome Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Vesicle Targeting	Membrane SNAP Receptor Activity Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex Protein Binding Membrane Fusion Mitochondrial Membrane Endomembrane System Plasma Membrane Organelle Localization By Membrane Tethering Membrane Organization Cellular Localization Vesicle Membrane Docking Vesicle Fusion Vesicle Docking Organelle Membrane Fusion SNARE Binding Golgi Vesicle Transport C-4 Methylsterol Oxidase Activity Sterol Biosynthetic Process Vesicle Organization Organelle Fusion Connexin Complex B Cell Receptor Complex Gap Junction Channel Activity Nuclear Inner Membrane Localization Within Membrane Gap Junction
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