DHRS2 and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DHRS2	APPBP2
Description		dehydrogenase/reductase 2	amyloid beta precursor protein binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Carbonyl Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	C21-steroid Hormone Metabolic Process Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Electron Transport Chain Cellular Response To Oxidative Stress Myeloid Dendritic Cell Differentiation Negative Regulation Of Apoptotic Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport
Pathways
Drugs
Diseases
GWAS			Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		5 interacting genes: APPBP2 EXOSC5 FBXO7 TCEA2 ZHX2	122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		10202	10513
HPRD ID		07483	05616
Ensembl ID		ENSG00000100867	ENSG00000062725
Uniprot IDs		Q13268	Q92624
PDB IDs			8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Ubiquitin-like Ligase-substrate Adaptor Activity Macromolecule Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite MRNA Catabolic Process Nucleoplasm Catabolic Process Lewy Body Core RNA Catabolic Process Macromolecule Metabolic Process Exoribonuclease Complex RNA Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glutamatergic Neuron Differentiation Retinal Bipolar Neuron Differentiation Nucleobase-containing Compound Catabolic Process Protein Heterodimerization Activity Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) RNA Exonuclease Activity Sno(s)RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Cul2-RING Ubiquitin Ligase Complex Transcription Elongation Factor Complex Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SnRNA 3'-end Processing Nucleus Positive Regulation Of Mitophagy Proteasomal Protein Catabolic Process	Protein Binding
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