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UBTF and CCNE1
Number of citations of the paper that reports this interaction (PMID
10202152
)
43
Data Source:
BioGRID
(enzymatic study)
UBTF
CCNE1
Gene Name
upstream binding transcription factor, RNA polymerase I
cyclin E1
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Nucleolus
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Poly(A) RNA Binding
Transcription Coactivator Activity
Protein Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Androgen Receptor Binding
Biological Process
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase I Promoter
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Gene Expression
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription From RNA Polymerase I Promoter
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication Initiation
Protein Phosphorylation
Wnt Signaling Pathway
Androgen Receptor Signaling Pathway
Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Cell Division
Regulation Of Cell Cycle
Pathways
NoRC negatively regulates rRNA expression
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
RNA Polymerase I Promoter Clearance
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
RNA Polymerase I Promoter Opening
E2F mediated regulation of DNA replication
DNA Damage/Telomere Stress Induced Senescence
Cellular Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
p53-Dependent G1/S DNA damage checkpoint
G0 and Early G1
S Phase
Cyclin E associated events during G1/S transition
Cell Cycle, Mitotic
p53-Dependent G1 DNA Damage Response
SCF(Skp2)-mediated degradation of p27/p21
G1/S Transition
G1/S-Specific Transcription
Cell Cycle Checkpoints
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic G1-G1/S phases
G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS
Bladder cancer (
20972438
)
Protein-Protein Interactions
31 interactors:
CCNA2
CCND1
CCNE1
CD3EAP
CDK2
CDK4
CENPC
CHGB
CREBBP
CSNK2A1
IRS1
IRS2
LEF1
MAD1L1
MAPK1
MAPK3
MDM2
POLR1E
RB1
RBL2
RUNX2
SERPINH1
SMURF1
TAF1
TAF1A
TAF1B
TAF1C
TAF1D
TBP
TCOF1
ZMYM2
46 interactors:
AR
ARHGEF5
ARID4A
BRCA2
BTRC
CABLES1
CALM1
CCT4
CDC25A
CDC34
CDC6
CDK1
CDK2
CDK3
CDKN1A
COIL
CUL3
FBXW7
FOXM1
GSK3B
H1F0
HERC5
HIST1H1A
HIST1H1B
MARCKS
MCM3
MRE11A
MYBL2
NBN
PIN1
POLD1
PRC1
PRKAR1A
RB1
RBL1
RBL2
RBX1
REL
RHOBTB3
RRN3
SKP2
SMARCA4
SMARCC1
SMARCD3
TP73
UBTF
Entrez ID
7343
898
HPRD ID
02814
00455
Ensembl ID
ENSG00000108312
ENSG00000105173
Uniprot IDs
P17480
P24864
PDB IDs
1K99
1L8Y
1L8Z
2HDZ
1W98
Enriched GO Terms of Interacting Partners
?
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription Elongation From RNA Polymerase I Promoter
DNA-templated Transcription, Initiation
DNA-templated Transcription, Elongation
Regulation Of Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Metabolic Process
Macromolecule Biosynthetic Process
DNA-templated Transcription, Termination
Negative Regulation Of Gene Expression, Epigenetic
Chromatin Silencing At RDNA
Cellular Macromolecule Biosynthetic Process
Gene Expression
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Cycle
Regulation Of Cell Cycle Phase Transition
RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Chromatin Silencing
Regulation Of RNA Biosynthetic Process
Mitotic Cell Cycle
Positive Regulation Of Macromolecule Biosynthetic Process
Mitotic Cell Cycle Checkpoint
Regulation Of RNA Metabolic Process
Cell Division
Positive Regulation Of Cellular Biosynthetic Process
Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
Negative Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cell Proliferation
Regulation Of Cell Cycle Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Mitotic Cell Cycle Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cell Cycle Checkpoint
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
RRNA Transcription
Cell Cycle
Regulation Of Cell Cycle
Mitotic Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Mitotic Cell Cycle Process
Organelle Organization
Chromosome Organization
Positive Regulation Of Cellular Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Positive Regulation Of Metabolic Process
Regulation Of Kinase Activity
Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cellular Biosynthetic Process
Chromatin Organization
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
DNA Metabolic Process
Regulation Of Protein Phosphorylation
Negative Regulation Of Cell Cycle
Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
DNA Replication
Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of DNA Replication
Heterocycle Metabolic Process
Cell Division
Cellular Aromatic Compound Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Protein Kinase Activity
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Chromatin Modification
Cell Cycle Checkpoint
Negative Regulation Of Biosynthetic Process
Regulation Of Cell Cycle Phase Transition
Tagcloud
?
augments
becomes
cd31
cdkn1a
cdkn2a
clorgyline
combines
conjugate
degrades
dye
emt
goals
hypoxic
inactivating
infrared
m30
maoa
micromolar
modern
moiety
monoamine
monoamines
multidisciplinary
neurotransmitters
nfkb
nmi
oncogenes
pca
pharmacology
Tagcloud (Difference)
?
augments
becomes
cd31
cdkn1a
cdkn2a
clorgyline
combines
conjugate
degrades
dye
emt
goals
hypoxic
inactivating
infrared
m30
maoa
micromolar
modern
moiety
monoamine
monoamines
multidisciplinary
neurotransmitters
nfkb
nmi
oncogenes
pca
pharmacology
Tagcloud (Intersection)
?