UBTF and CENPC

Number of citations of the paper that reports this interaction (PMID 8702533)
11

Data Source:
HPRD (in vitro, in vivo)

		UBTF	CENPC
Gene Name		upstream binding transcription factor, RNA polymerase I	centromere protein C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding	DNA Binding Centromeric DNA Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase I Promoter	Mitotic Cell Cycle Nucleosome Assembly Chromosome Segregation Mitotic Nuclear Division CENP-A Containing Nucleosome Assembly Cell Division Kinetochore Assembly
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase I Promoter Opening	Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: CCNA2 CCND1 CCNE1 CD3EAP CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2	6 interactors: DAXX MAPK14 MDC1 SUMO2 TCEB1 UBTF
Entrez ID		7343	1060
HPRD ID		02814	00315
Ensembl ID		ENSG00000108312	ENSG00000145241
Uniprot IDs		P17480	Q03188 Q6PIR0
PDB IDs		1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter DNA-templated Transcription, Initiation DNA-templated Transcription, Elongation Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Chromatin Silencing At RDNA Cellular Macromolecule Biosynthetic Process Gene Expression Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Regulation Of Cell Cycle Phase Transition RNA Metabolic Process Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Chromatin Silencing Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Checkpoint Regulation Of RNA Metabolic Process Cell Division Positive Regulation Of Cellular Biosynthetic Process Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression, Epigenetic Negative Regulation Of Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Checkpoint Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway RRNA Transcription	Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Elongation Cellular Response To Stress P38MAPK Cascade Positive Regulation Of Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity DNA Damage Checkpoint Chromatin Remodeling Transcription, DNA-templated Positive Regulation Of MAP Kinase Activity Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration RNA Biosynthetic Process MAPK Cascade Nucleobase-containing Compound Metabolic Process Cell Cycle Checkpoint Regulation Of Brown Fat Cell Differentiation Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Cellular Nitrogen Compound Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process 3'-UTR-mediated MRNA Stabilization Intra-S DNA Damage Checkpoint Positive Regulation Of Transcription From RNA Polymerase I Promoter Stress-induced Premature Senescence Positive Regulation Of Transcription, DNA-templated Cell Cycle Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Response To Muramyl Dipeptide Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of MAPK Cascade Positive Regulation Of Erythrocyte Differentiation Response To Stress Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion
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