TGFBR1 and RAB38

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		TGFBR1	RAB38
Gene Name		transforming growth factor, beta receptor 1	RAB38, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cell Endosome Plasma Membrane Tight Junction Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex	Early Endosome Endoplasmic Reticulum Trans-Golgi Network Cytosol Plasma Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Lumen Melanosome Phagocytic Vesicle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Receptor Signaling Protein Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding Growth Factor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding I-SMAD Binding	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding AP-2 Adaptor Complex Binding AP-1 Adaptor Complex Binding AP-3 Adaptor Complex Binding BLOC-2 Complex Binding
	Biological Process	Activation Of MAPKK Activity Skeletal System Development Angiogenesis In Utero Embryonic Development Kidney Development Blastocyst Development Epithelial To Mesenchymal Transition Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lens Development In Camera-type Eye Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Arrest Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Proliferation Germ Cell Migration Male Gonad Development Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Intracellular Signal Transduction Wound Healing Endothelial Cell Activation Extracellular Structure Organization Regulation Of Protein Binding Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Thymus Development Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Mesenchymal Cell Differentiation Artery Morphogenesis Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Palate Development Pharyngeal System Development Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Response To Cholesterol Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Intracellular Protein Transport Small GTPase Mediated Signal Transduction Protein Transport Rab Protein Signal Transduction Endosome To Melanosome Transport Platelet Dense Granule Organization Protein Localization To Membrane Phagosome Acidification Melanosome Assembly
Pathways		Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23455636) Dental caries ( 23064961)	Multiple sclerosis (age of onset) ( 19010793)
Protein-Protein Interactions		159 interactors: ACVR1 ACVRL1 AMHR2 ANAPC5 AP2B1 ARHGAP15 ARHGAP31 ARHGEF6 ARL4D ARL8B ASH2L AURKB BAMBI BMPR1B BMPR2 BTBD2 CAV1 CD44 CDC20 CDC42EP4 CDK14 CDK17 CDK4 CDK6 CDKL1 CHN1 CHN2 CHUK CLU CSNK1A1 CSNK2A2 CTNNB1 CUL5 DAB2 DAPK2 DCAF12 DCAF6 DUSP13 EIF2AK4 ENC1 ENG FANCL FBXL12 FBXO34 FKBP1A FNTA GNA13 GNB2 GNB3 IKBKB ITK KATNB1 KCNK18 KLHL1 KLHL35 LIMS1 MAP3K7 MYO3A MYOC NAT8 NEK6 NEK8 NKIRAS1 NRP1 NUAK2 NUP37 OSR1 OXSR1 PAK1 PARD6A PIK3R1 PIK3R2 PLEK PLEKHB1 PLEKHJ1 PLK4 PML POMK PPP2R2A PPP3CC PPP6C PREB PREX2 PRPF4 RAB13 RAB25 RAB33B RAB34 RAB38 RAB3B RAB6B RAN RAP2A RASD2 RASL12 RGS19 RHEBL1 RHOA RHOD RHOG RHOH RHOJ RHPN2 RNF130 RNF146 RNF5 RPAP3 RPS27A RRH RTKN SAMD8 SAT2 SKAP2 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 SMURF2 SNTG1 SNX6 SOCS6 SQSTM1 STK35 STRAP STUB1 STX8 STYXL1 TGFB1 TGFB2 TGFB3 TGFBR2 TGFBRAP1 TNNT1 TRAF6 TRAP1 TSC22D1 TSSK1B TSSK4 TTC1 TTC27 TTPAL UBA52 UBB UBD UBE2E3 UBE2Z UBXN1 USP4 USP45 VEPH1 WDR13 WDR33 WDR61 XIAP ZAK ZFYVE9	7 interactors: APP BMPR1B SMAD1 SMAD2 SMAD3 SMAD4 TGFBR1
Entrez ID		7046	23682
HPRD ID		01822	05889
Ensembl ID		ENSG00000106799	ENSG00000123892
Uniprot IDs		P36897 Q5T7S2	P57729
PDB IDs		1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signal Transduction Response To Transforming Growth Factor Beta Signal Transduction Cell Communication Signaling Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Cellular Response To Stimulus Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Modification Process Regulation Of Signaling Response To Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Organic Substance Protein Phosphorylation Phosphorylation Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Organization Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Process Signal Transduction By Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cell Morphogenesis SMAD Protein Complex Assembly Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial To Mesenchymal Transition	SMAD Protein Complex Assembly Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Primary MiRNA Processing Cellular Response To Transforming Growth Factor Beta Stimulus Pattern Specification Process Response To Transforming Growth Factor Beta Growth Regulation Of Epithelial To Mesenchymal Transition Regulation Of Binding Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Developmental Growth Regulation Of Cartilage Development Regulation Of Cell Differentiation Kidney Development Renal System Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Regulation Of Cell Development Mesonephros Development Enzyme Linked Receptor Protein Signaling Pathway Urogenital System Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Mesoderm Development Positive Regulation Of Epithelial To Mesenchymal Transition Kidney Epithelium Development Regulation Of Cell Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Activin Receptor Signaling Pathway Heart Development Gastrulation Gene Silencing By MiRNA Positive Regulation Of Cartilage Development Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To DsRNA Anatomical Structure Morphogenesis Skeletal System Development Cellular Response To Growth Factor Stimulus Mesenchyme Development Posttranscriptional Gene Silencing Response To Growth Factor Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Stem Cell Differentiation Embryonic Morphogenesis SMAD Protein Signal Transduction Anterior/posterior Pattern Specification Regulation Of Cell Proliferation
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc vav2 wilcoxon yes zfyve9	aminoterminus autophagic closest coil coiled endosomal endosomes fractionation gfp golgi gtpase gtpases heritable homologue leucine lrrk2 melanogenesis melanogenic mvbs organize perinuclear phagocytosis rab32 rab7 recycling sorting subcellular transport vesicles
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc vav2 wilcoxon yes zfyve9	aminoterminus autophagic closest coil coiled endosomal endosomes fractionation gfp golgi gtpase gtpases heritable homologue leucine lrrk2 melanogenesis melanogenic mvbs organize perinuclear phagocytosis rab32 rab7 recycling sorting subcellular transport vesicles
Tagcloud (Intersection) ?