TGFBR1 and TGFB1

Number of citations of the paper that reports this interaction (PubMedID 8235612)
0

Data Source:
HPRD (in vivo)

		TGFBR1	TGFB1
Description		transforming growth factor beta receptor 1	transforming growth factor beta 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Plasma Membrane Bicellular Tight Junction Cilium Cell Surface Membrane Receptor Complex Membrane Raft Activin Receptor Complex Transforming Growth Factor Beta Ligand-receptor Complex Anchoring Junction Serine/threonine Protein Kinase Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Microvillus Cell Surface Secretory Granule Axon Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body Blood Microparticle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Growth Factor Binding Ubiquitin Protein Ligase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding I-SMAD Binding	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Enzyme Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Deubiquitinase Activator Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding
	Biological Process	Skeletal System Development Angiogenesis In Utero Embryonic Development Kidney Development Blastocyst Development Epithelial To Mesenchymal Transition Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lens Development In Camera-type Eye Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Proepicardium Development Regulation Of DNA-templated Transcription Apoptotic Process Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Germ Cell Migration Male Gonad Development Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Peptidyl-serine Phosphorylation Cell Differentiation Collagen Fibril Organization Positive Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Regulation Of Protein Ubiquitination Negative Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Intracellular Signal Transduction Myofibroblast Differentiation Wound Healing Endothelial Cell Activation Extracellular Structure Organization Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Endothelial Cell Migration Positive Regulation Of DNA-templated Transcription Filopodium Assembly Thymus Development Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Mesenchymal Cell Differentiation Artery Morphogenesis Cell Motility Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Parathyroid Gland Development Roof Of Mouth Development Pharyngeal System Development Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Trophoblast Cell Migration Response To Cholesterol Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Alcohol Vascular Endothelial Cell Proliferation Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Vasculature Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Epicardium Morphogenesis Regulation Of Multicellular Organismal Development Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Ureteric Bud Development Response To Hypoxia Morphogenesis Of A Branching Structure Cell Activation Epithelial To Mesenchymal Transition Neural Tube Closure Regulation Of Sodium Ion Transport Sprouting Angiogenesis Chondrocyte Differentiation Columnar/cuboidal Epithelial Cell Maturation Hematopoietic Progenitor Cell Differentiation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tolerance Induction To Self Antigen Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Heart Valve Morphogenesis Aortic Valve Morphogenesis Protein Export From Nucleus ATP Biosynthetic Process Phosphate-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis Apoptotic Process Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Negative Regulation Of Neuroblast Proliferation Salivary Gland Morphogenesis Endoderm Development Heart Development Female Pregnancy Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Germ Cell Migration Response To Xenobiotic Stimulus Response To Wounding Response To Glucose Gene Expression Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Epithelial To Mesenchymal Transition Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Negative Regulation Of Macrophage Cytokine Production Oligodendrocyte Development Positive Regulation Of Microglia Differentiation Regulation Of Striated Muscle Tissue Development Neural Tube Development Hyaluronan Catabolic Process T Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Growth Osteoclast Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Mammary Gland Development Animal Organ Regeneration Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Exit From Mitosis Response To Estradiol Response To Progesterone Regulation Of Interleukin-23 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Receptor Catabolic Process Positive Regulation Of Superoxide Anion Generation Mononuclear Cell Proliferation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Response To Vitamin D Response To Laminar Fluid Shear Stress Response To Immobilization Stress Myofibroblast Differentiation T Cell Proliferation T Cell Activation Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Myelination T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of Canonical NF-kappaB Signal Transduction Surfactant Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulatory T Cell Differentiation Cell-cell Junction Organization Response To Ethanol Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Positive Regulation Of Isotype Switching To IgA Isotypes Lymph Node Development Digestive Tract Development Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Smooth Muscle Cell Proliferation Inner Ear Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Fungus Negative Regulation Of T Cell Activation Positive Regulation Of Chemotaxis Positive Regulation Of Cellular Component Organization Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Regulation Of Cell Cycle Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ventricular Cardiac Muscle Tissue Morphogenesis Phospholipid Homeostasis Canonical Wnt Signaling Pathway Regulation Of Blood Vessel Remodeling Face Morphogenesis Frontal Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Bronchiole Development Mammary Gland Branching Involved In Thelarche Branch Elongation Involved In Mammary Gland Duct Branching Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Connective Tissue Development Langerhans Cell Differentiation Negative Regulation Of Biomineral Tissue Development Regulation Of Enamel Mineralization Lens Fiber Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mononuclear Cell Migration Odontoblast Differentiation Stem Cell Proliferation Extracellular Matrix Assembly Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Liver Regeneration Cellular Response To Virus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Extracellular Matrix Assembly Response To Salt Positive Regulation Of Mesenchymal Stem Cell Proliferation Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vasculature Development Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cellular Response To Acetaldehyde Cellular Response To Insulin-like Growth Factor Stimulus Embryonic Liver Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Primary MiRNA Processing Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer UCH proteinases Ub-specific processing proteases TGFBR3 regulates TGF-beta signaling	Platelet degranulation Influenza Virus Induced Apoptosis Cell surface interactions at the vascular wall Molecules associated with elastic fibres Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Syndecan interactions ECM proteoglycans SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Transcriptional regulation of white adipocyte differentiation UCH proteinases Interleukin-4 and Interleukin-13 signaling RUNX3 regulates CDKN1A transcription Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF TGFBR3 regulates TGF-beta signaling
Drugs		4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline Naphthyridine Inhibitor 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine Fostamatinib	Hyaluronidase (ovine) Terazosin Hyaluronidase (human recombinant) Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Hyaluronidase
Diseases		Loeys-Dietz syndrome (LDS) Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)	Graft-versus-host disease Allograft rejection Camurati-Engelmann disease; Progressive diaphyseal dysplasia
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636) Asthma ( 31959851 32296059 34103634) Callous-unemotional behaviour ( 23874384) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Dental caries ( 23064961) Epithelial ovarian cancer ( 25134534) Fractures (paediatric) ( 32742401) Gestational age at birth (maternal effect) ( 28877031) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Colorectal cancer ( 24836286 27145994) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 28714974 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Platelet count ( 32888494) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 30578418) Type 2 diabetes ( 31049640)
Interacting Genes		164 interacting genes: ACVR1 ACVRL1 AMHR2 ANAPC5 AP2B1 ARHGAP15 ARHGAP31 ARHGEF6 ARL4D ARL8B ASH2L AURKB BAMBI BMPR1B BMPR2 BTBD2 CAV1 CD44 CDC20 CDC42EP4 CDK14 CDK17 CDK4 CDK6 CDKL1 CHN1 CHN2 CHUK CLU CSNK1A1 CSNK2A2 CTNNB1 CUL5 DAB2 DAPK2 DCAF12 DCAF6 DUSP13B EIF2AK4 ENC1 ENG FANCL FBXL12 FBXO34 FKBP1A FKBP1B FNTA GNA13 GNB2 GNB3 IKBKB ITK KATNB1 KCNK18 KLHL1 KLHL35 LIMS1 LITATS1 MAP3K20 MAP3K7 MYO3A MYOC MYT1L NAT8 NEK6 NEK8 NKIRAS1 NRP1 NUAK2 NUP37 OSR1 OTUB1 OXSR1 PAK1 PARD6A PIK3R1 PIK3R2 PLEK PLEKHB1 PLEKHJ1 PLK4 PML POMK PPP2R2A PPP3CC PPP6C PREB PREX2 PRPF4 RAB13 RAB25 RAB33B RAB34 RAB38 RAB3B RAB6B RAN RAP2A RASD2 RASL12 RGS19 RHEBL1 RHOA RHOD RHOG RHOH RHOJ RHPN2 RNF130 RNF146 RNF5 RPAP3 RPS27A RRH RTKN SAMD8 SAT2 SKAP2 SKI SKIC8 SMAD1 SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 SMURF2 SNTG1 SNX6 SOCS6 SQSTM1 STK35 STRAP STUB1 STX8 STYXL1 TGFB1 TGFB2 TGFB3 TGFBR2 TGFBRAP1 TNNT1 TRAF6 TRAP1 TSC22D1 TSSK1B TSSK4 TTC1 TTC27 TTPAL UBA52 UBB UBD UBE2E3 UBE2Z UBXN1 USP14 USP2 USP45 VEPH1 WDR13 WDR33 XIAP ZFYVE9	99 interacting genes: ACVRL1 ADAMTSL4 AGR3 ANGPTL4 APC APP AURKA AXIN2 BCAS3 BCL10 BGN BLID BMP2 BMP3 BMPR1A BUB1 CATSPER1 CCDC33 CCL3 CCL5 CCN2 CDKN2A CFTR COL2A1 CST6 CYSRT1 DAXX DCN DIRAS3 DLC1 DPT EGFR EIF3I ENG ERBB2 FBXW7 FCHO1 FCN1 FKBP1A FMOD FNTA GREB1 HOXA1 HOXC6 ITGAV ITGB6 ITGB8 KLK5 KLK7 KLK9 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP4-11 LAMTOR5 LCE1A LCE1C LCE1D LCE1F LCE2B LCE2C LCE3A LCE3B LCE3D LCE5A LPXN LTBP1 LTBP3 LTBP4 MCC MEOX2 MLH3 MMP2 MTA3 NSD3 P4HB PDGFRL PDLIM2 POU4F2 PRSS50 PSMC3IP PZP RAPGEF3 SCGB3A1 SDC2 SNAI1 SPARC ST14 TGFB2 TGFBR1 TGFBR2 TGFBR3 THBS1 THRSP TLR2 UBC VASN VTN YWHAE
Entrez ID		7046	7040
HPRD ID		01822	01821
Ensembl ID		ENSG00000106799	ENSG00000105329
Uniprot IDs		B4DXN7 B4DY26 F8W0K6 P36897 Q5T7S2	A0A499FJK2 P01137
PDB IDs		1B6C 1IAS 1PY5 1RW8 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM 4X0M 4X2F 4X2G 4X2J 4X2K 4X2N 5E8S 5E8T 5E8U 5E8W 5E8X 5E8Z 5E90 5FRI 5QIK 5QIL 5QIM 5QTZ 5QU0 5USQ 6B8Y 6MAC 8YHF 8YHL 9B9F 9F6X 9FK5	1KLA 1KLC 1KLD 3KFD 4KV5 5FFO 5VQP 6OM2 6P7J 7Y1R 7Y1T 8UDZ 8VSC 8VSD 9FDY 9FKP
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Intracellular Signaling Cassette Signal Transduction Protein Serine/threonine Kinase Activity Nucleotide Binding Protein Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Type I Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Intracellular Signal Transduction Regulation Of SMAD Protein Signal Transduction SMAD Binding Cytosol Kinase Activity Response To Growth Factor GTPase Activity Cell Surface Receptor Signaling Pathway Protein Modification Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of SMAD Protein Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Positive Regulation Of Epithelial To Mesenchymal Transition I-SMAD Binding Modification-dependent Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Epithelial To Mesenchymal Transition GTP Binding Regulation Of Cellular Response To Growth Factor Stimulus Heteromeric SMAD Protein Complex Transferase Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Binding SMAD Protein Signal Transduction Post-translational Protein Modification	Transforming Growth Factor Beta Binding Tissue Development Epidermis Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Developmental Process Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Extracellular Matrix Cell Surface Receptor Signaling Pathway Keratinization Endocardial Cushion Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Positive Regulation Of SMAD Protein Signal Transduction Extracellular Space Regulation Of Cell Migration Cardiac Epithelial To Mesenchymal Transition Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Extracellular Matrix Organization Extracellular Structure Organization Activin Binding Positive Regulation Of Cell Migration Glycosaminoglycan Binding Regulation Of Multicellular Organismal Process Regulation Of Epithelial Cell Proliferation Response To Growth Factor Cell Surface Positive Regulation Of Cell Motility Regulation Of SMAD Protein Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Locomotion Extracellular Region Regulation Of Programmed Cell Death Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Roof Of Mouth Development Extracellular Matrix Binding Regulation Of Apoptotic Process Regulation Of Signal Transduction Epithelial To Mesenchymal Transition Heart Morphogenesis Cardiac Muscle Tissue Morphogenesis
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