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TGFBR1 and SAMD8
Number of citations of the paper that reports this interaction (PMID
15761153
)
154
Data Source:
HPRD
(in vivo)
TGFBR1
SAMD8
Gene Name
transforming growth factor, beta receptor 1
sterile alpha motif domain containing 8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cell
Endosome
Plasma Membrane
Tight Junction
Membrane
Receptor Complex
Transforming Growth Factor Beta Receptor Homodimeric Complex
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Receptor Signaling Protein Activity
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
ATP Binding
Growth Factor Binding
SMAD Binding
Metal Ion Binding
Transforming Growth Factor Beta Binding
I-SMAD Binding
Molecular_function
Transferase Activity
Biological Process
Activation Of MAPKK Activity
Skeletal System Development
Angiogenesis
In Utero Embryonic Development
Kidney Development
Blastocyst Development
Epithelial To Mesenchymal Transition
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lens Development In Camera-type Eye
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Apoptotic Process
Cell Cycle Arrest
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Heart Development
Positive Regulation Of Cell Proliferation
Germ Cell Migration
Male Gonad Development
Post-embryonic Development
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Signal Transduction By Phosphorylation
Collagen Fibril Organization
Positive Regulation Of Cell Growth
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Chondrocyte Differentiation
Activin Receptor Signaling Pathway
Intracellular Signal Transduction
Wound Healing
Endothelial Cell Activation
Extracellular Structure Organization
Regulation Of Protein Binding
Endothelial Cell Migration
Positive Regulation Of Transcription, DNA-templated
Thymus Development
Neuron Fate Commitment
Embryonic Cranial Skeleton Morphogenesis
Skeletal System Morphogenesis
Mesenchymal Cell Differentiation
Artery Morphogenesis
Cell Motility
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Protein Kinase B Signaling
Parathyroid Gland Development
Palate Development
Pharyngeal System Development
Cardiac Epithelial To Mesenchymal Transition
Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of SMAD Protein Import Into Nucleus
Response To Cholesterol
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Sphingomyelin Biosynthetic Process
Ceramide Biosynthetic Process
Regulation Of Ceramide Biosynthetic Process
Pathways
Loss of Function of TGFBR2 in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Age-related macular degeneration (
23455636
)
Dental caries (
23064961
)
Protein-Protein Interactions
159 interactors:
ACVR1
ACVRL1
AMHR2
ANAPC5
AP2B1
ARHGAP15
ARHGAP31
ARHGEF6
ARL4D
ARL8B
ASH2L
AURKB
BAMBI
BMPR1B
BMPR2
BTBD2
CAV1
CD44
CDC20
CDC42EP4
CDK14
CDK17
CDK4
CDK6
CDKL1
CHN1
CHN2
CHUK
CLU
CSNK1A1
CSNK2A2
CTNNB1
CUL5
DAB2
DAPK2
DCAF12
DCAF6
DUSP13
EIF2AK4
ENC1
ENG
FANCL
FBXL12
FBXO34
FKBP1A
FNTA
GNA13
GNB2
GNB3
IKBKB
ITK
KATNB1
KCNK18
KLHL1
KLHL35
LIMS1
MAP3K7
MYO3A
MYOC
NAT8
NEK6
NEK8
NKIRAS1
NRP1
NUAK2
NUP37
OSR1
OXSR1
PAK1
PARD6A
PIK3R1
PIK3R2
PLEK
PLEKHB1
PLEKHJ1
PLK4
PML
POMK
PPP2R2A
PPP3CC
PPP6C
PREB
PREX2
PRPF4
RAB13
RAB25
RAB33B
RAB34
RAB38
RAB3B
RAB6B
RAN
RAP2A
RASD2
RASL12
RGS19
RHEBL1
RHOA
RHOD
RHOG
RHOH
RHOJ
RHPN2
RNF130
RNF146
RNF5
RPAP3
RPS27A
RRH
RTKN
SAMD8
SAT2
SKAP2
SKI
SMAD1
SMAD2
SMAD3
SMAD4
SMAD6
SMAD7
SMURF2
SNTG1
SNX6
SOCS6
SQSTM1
STK35
STRAP
STUB1
STX8
STYXL1
TGFB1
TGFB2
TGFB3
TGFBR2
TGFBRAP1
TNNT1
TRAF6
TRAP1
TSC22D1
TSSK1B
TSSK4
TTC1
TTC27
TTPAL
UBA52
UBB
UBD
UBE2E3
UBE2Z
UBXN1
USP4
USP45
VEPH1
WDR13
WDR33
WDR61
XIAP
ZAK
ZFYVE9
1 interactors:
TGFBR1
Entrez ID
7046
142891
HPRD ID
01822
18014
Ensembl ID
ENSG00000106799
ENSG00000156671
Uniprot IDs
P36897
Q5T7S2
Q96LT4
PDB IDs
1B6C
1IAS
1PY5
1RW8
1TBI
1VJY
2L5S
2PJY
2WOT
2WOU
2X7O
3FAA
3GXL
3HMM
3KCF
3KFD
3TZM
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Intracellular Signal Transduction
Response To Transforming Growth Factor Beta
Signal Transduction
Cell Communication
Signaling
Cellular Response To Growth Factor Stimulus
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Response To Growth Factor
Cellular Response To Stimulus
Regulation Of Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Protein Modification Process
Regulation Of Signaling
Response To Stimulus
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Protein Metabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Cellular Process
Positive Regulation Of Signal Transduction
Cellular Response To Organic Substance
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Response To Organic Substance
Protein Phosphorylation
Phosphorylation
Cell Surface Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Regulation Of Cellular Component Organization
Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Metabolic Process
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Process
Signal Transduction By Phosphorylation
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Regulation Of Phosphorylation
Regulation Of Cell Morphogenesis
SMAD Protein Complex Assembly
Regulation Of Cell Death
Negative Regulation Of Signal Transduction
Regulation Of Phosphorus Metabolic Process
Regulation Of Epithelial To Mesenchymal Transition
Parathyroid Gland Development
Endothelial Cell Activation
Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of SMAD Protein Import Into Nucleus
Regulation Of SMAD Protein Import Into Nucleus
Germ Cell Migration
Pharyngeal System Development
Response To Cholesterol
Negative Regulation Of Chondrocyte Differentiation
Cardiac Epithelial To Mesenchymal Transition
Activin Receptor Signaling Pathway
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cartilage Development
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Filopodium Assembly
Peptidyl-threonine Phosphorylation
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Artery Morphogenesis
Epithelial To Mesenchymal Transition
Regulation Of Epithelial To Mesenchymal Transition
Thymus Development
Collagen Fibril Organization
Positive Regulation Of Endothelial Cell Proliferation
Artery Development
Embryonic Cranial Skeleton Morphogenesis
Activation Of MAPKK Activity
Regulation Of Chondrocyte Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Neuron Fate Commitment
Endothelial Cell Migration
Regulation Of Endothelial Cell Proliferation
Regulation Of Cartilage Development
Positive Regulation Of Protein Import Into Nucleus
Lens Development In Camera-type Eye
Epithelial Cell Migration
Epithelium Migration
Blastocyst Development
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Palate Development
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Nucleocytoplasmic Transport
Positive Regulation Of Protein Localization To Nucleus
Mesenchymal Cell Development
Regulation Of Cell Projection Assembly
Peptidyl-serine Phosphorylation
Positive Regulation Of Cell Growth
Embryonic Skeletal System Morphogenesis
Tagcloud
?
calm3
cblb
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
vav2
wilcoxon
yes
zfyve9
Tagcloud (Difference)
?
calm3
cblb
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
vav2
wilcoxon
yes
zfyve9
Tagcloud (Intersection)
?