TGFBR1 and DAPK2

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		TGFBR1	DAPK2
Description		transforming growth factor beta receptor 1	death associated protein kinase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Plasma Membrane Bicellular Tight Junction Cilium Cell Surface Membrane Receptor Complex Membrane Raft Activin Receptor Complex Transforming Growth Factor Beta Ligand-receptor Complex Anchoring Junction Serine/threonine Protein Kinase Complex	Nucleus Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Autophagosome Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Growth Factor Binding Ubiquitin Protein Ligase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding I-SMAD Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Skeletal System Development Angiogenesis In Utero Embryonic Development Kidney Development Blastocyst Development Epithelial To Mesenchymal Transition Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lens Development In Camera-type Eye Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Proepicardium Development Regulation Of DNA-templated Transcription Apoptotic Process Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Germ Cell Migration Male Gonad Development Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Peptidyl-serine Phosphorylation Cell Differentiation Collagen Fibril Organization Positive Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Regulation Of Protein Ubiquitination Negative Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Intracellular Signal Transduction Myofibroblast Differentiation Wound Healing Endothelial Cell Activation Extracellular Structure Organization Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Endothelial Cell Migration Positive Regulation Of DNA-templated Transcription Filopodium Assembly Thymus Development Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Mesenchymal Cell Differentiation Artery Morphogenesis Cell Motility Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Parathyroid Gland Development Roof Of Mouth Development Pharyngeal System Development Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Trophoblast Cell Migration Response To Cholesterol Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Alcohol Vascular Endothelial Cell Proliferation Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Vasculature Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Epicardium Morphogenesis Regulation Of Multicellular Organismal Development Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Positive Regulation Of Neutrophil Chemotaxis Neutrophil Migration Positive Regulation Of Eosinophil Chemotaxis Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer UCH proteinases Ub-specific processing proteases TGFBR3 regulates TGF-beta signaling	Caspase activation via Dependence Receptors in the absence of ligand
Drugs		4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline Naphthyridine Inhibitor 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine Fostamatinib	Fostamatinib
Diseases		Loeys-Dietz syndrome (LDS) Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636) Asthma ( 31959851 32296059 34103634) Callous-unemotional behaviour ( 23874384) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Dental caries ( 23064961) Epithelial ovarian cancer ( 25134534) Fractures (paediatric) ( 32742401) Gestational age at birth (maternal effect) ( 28877031) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Arterial stiffness index ( 31235810) Cerebral amyloid deposition (PET imaging) ( 30361487) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) HDL cholesterol levels ( 32203549) Platelet distribution width ( 27863252) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Triglyceride levels ( 31647587) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		164 interacting genes: ACVR1 ACVRL1 AMHR2 ANAPC5 AP2B1 ARHGAP15 ARHGAP31 ARHGEF6 ARL4D ARL8B ASH2L AURKB BAMBI BMPR1B BMPR2 BTBD2 CAV1 CD44 CDC20 CDC42EP4 CDK14 CDK17 CDK4 CDK6 CDKL1 CHN1 CHN2 CHUK CLU CSNK1A1 CSNK2A2 CTNNB1 CUL5 DAB2 DAPK2 DCAF12 DCAF6 DUSP13B EIF2AK4 ENC1 ENG FANCL FBXL12 FBXO34 FKBP1A FKBP1B FNTA GNA13 GNB2 GNB3 IKBKB ITK KATNB1 KCNK18 KLHL1 KLHL35 LIMS1 LITATS1 MAP3K20 MAP3K7 MYO3A MYOC MYT1L NAT8 NEK6 NEK8 NKIRAS1 NRP1 NUAK2 NUP37 OSR1 OTUB1 OXSR1 PAK1 PARD6A PIK3R1 PIK3R2 PLEK PLEKHB1 PLEKHJ1 PLK4 PML POMK PPP2R2A PPP3CC PPP6C PREB PREX2 PRPF4 RAB13 RAB25 RAB33B RAB34 RAB38 RAB3B RAB6B RAN RAP2A RASD2 RASL12 RGS19 RHEBL1 RHOA RHOD RHOG RHOH RHOJ RHPN2 RNF130 RNF146 RNF5 RPAP3 RPS27A RRH RTKN SAMD8 SAT2 SKAP2 SKI SKIC8 SMAD1 SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 SMURF2 SNTG1 SNX6 SOCS6 SQSTM1 STK35 STRAP STUB1 STX8 STYXL1 TGFB1 TGFB2 TGFB3 TGFBR2 TGFBRAP1 TNNT1 TRAF6 TRAP1 TSC22D1 TSSK1B TSSK4 TTC1 TTC27 TTPAL UBA52 UBB UBD UBE2E3 UBE2Z UBXN1 USP14 USP2 USP45 VEPH1 WDR13 WDR33 XIAP ZFYVE9	6 interacting genes: APP CAMK2A CCDC91 FAM9B MLC1 TGFBR1
Entrez ID		7046	23604
HPRD ID		01822	09905
Ensembl ID		ENSG00000106799	ENSG00000035664
Uniprot IDs		B4DXN7 B4DY26 F8W0K6 P36897 Q5T7S2	Q1RMF4 Q9UIK4
PDB IDs		1B6C 1IAS 1PY5 1RW8 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM 4X0M 4X2F 4X2G 4X2J 4X2K 4X2N 5E8S 5E8T 5E8U 5E8W 5E8X 5E8Z 5E90 5FRI 5QIK 5QIL 5QIM 5QTZ 5QU0 5USQ 6B8Y 6MAC 8YHF 8YHL 9B9F 9F6X 9FK5	1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE 6PAW 7A6R 7A6Y
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Intracellular Signaling Cassette Signal Transduction Protein Serine/threonine Kinase Activity Nucleotide Binding Protein Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Type I Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Intracellular Signal Transduction Regulation Of SMAD Protein Signal Transduction SMAD Binding Cytosol Kinase Activity Response To Growth Factor GTPase Activity Cell Surface Receptor Signaling Pathway Protein Modification Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of SMAD Protein Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Positive Regulation Of Epithelial To Mesenchymal Transition I-SMAD Binding Modification-dependent Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Epithelial To Mesenchymal Transition GTP Binding Regulation Of Cellular Response To Growth Factor Stimulus Heteromeric SMAD Protein Complex Transferase Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Binding SMAD Protein Signal Transduction Post-translational Protein Modification	Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Response To Cholesterol Membrane Raft Peptidyl-serine Phosphorylation Endosome Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Peptidyl-threonine Autophosphorylation Protein Phosphorylation Positive Regulation Of Hepatocyte Apoptotic Process Identical Protein Binding Regulation Of Cell Migration Regulation Of Apoptotic Signaling Pathway Phosphorylation Protein Serine/threonine Kinase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Locomotion Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Cell Motility Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Autophosphorylation Protein Kinase Activity Regulation Of Endocannabinoid Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Negative Regulation Of Canonical Wnt Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?