VTA1

Description		vesicle trafficking 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Multivesicular Body Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding
	Biological Process	Protein Transport Macroautophagy Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Sorting Pathway ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) FEV1 ( 30804560) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Retinal vascular caliber ( 21060863) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		22 interacting genes: APP BEX3 CBS CCNC CDK4 CHMP1A CHMP5 DPPA2 ERBB3 KCTD13 KLHL12 LYST MAGEA11 MBIP NBR1 NECAB2 RABAC1 RPIA SNCA TEAD4 ZBTB16 ZNRD2
Entrez ID		51534
HPRD ID		09855
Ensembl ID		ENSG00000009844
Uniprot IDs		A0A087WY55 Q9NP79
PDB IDs		2LXL 2LXM 4TXP 4TXQ 4TXR 4U7E
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Regulation Of MAPK Cascade ESCRT III Complex Viral Budding From Plasma Membrane Amphisome Membrane Lysosomal Membrane Organization Vesicle Fusion With Vacuole ESCRT III Complex Disassembly ESCRT Complex Disassembly Multivesicular Body-lysosome Fusion Protein Domain Specific Binding Presynapse Regulation Of Neurotransmitter Uptake Late Endosome To Lysosome Transport Kinetochore Microtubule Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Amyloid Fibril Formation Cytoplasm Cellular Response To Copper Ion Lysosomal Transport Vesicle Organization Plasma Membrane Repair Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Budding Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell Midbody Abscission Regulation Of Receptor Recycling Microglial Cell Activation Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Synaptic Transmission Leukocyte Activation Involved In Inflammatory Response Multivesicular Body Organization Multivesicular Body Assembly Regulation Of Spindle Assembly Response To Copper Ion Regulation Of JNK Cascade Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding
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