VTA1 and CHMP5

Number of citations of the paper that reports this interaction (PMID 16730941)
46

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		VTA1	CHMP5
Gene Name		vesicle (multivesicular body) trafficking 1	charged multivesicular body protein 5
Image
Gene Ontology Annotations	Cellular Component	Cytosol Endosome Membrane Extracellular Vesicular Exosome	Nucleus Cytosol Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein Transport Viral Process Endosomal Transport Viral Life Cycle Membrane Organization	Cell Separation After Cytokinesis Regulation Of Receptor Recycling Nucleus Organization Lysosome Organization Mitotic Metaphase Plate Congression Endosome To Lysosome Transport Regulation Of Centrosome Duplication Protein Transport Viral Process Endosomal Transport Viral Life Cycle Membrane Organization Regulation Of Mitotic Spindle Assembly
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Retinal vascular caliber ( 21060863)	Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		17 interactors: APP CBS CDK4 CHMP5 DPPA2 KCTD13 KLHL12 LYST MAGEA11 MBIP NBR1 NECAB2 NGFRAP1 RABAC1 RPIA SSSCA1 ZBTB16	15 interactors: APPBP2 CHMP1B CHMP4A CHMP4B GTF3A MITD1 PDCD10 RPL38 SMARCA4 STAMBP URGCP VPS4B VTA1 ZNF142 ZNF91
Entrez ID		51534	51510
HPRD ID		09855	15408
Ensembl ID			ENSG00000086065
Uniprot IDs		E7ETQ7 Q9NP79	Q9NZZ3
PDB IDs		2LXL 2LXM	2LXM 3ULY 3UM0 3UM1 3UM2
Enriched GO Terms of Interacting Partners?		Cell Division Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Lysosome Organization Positive Regulation Of Cell Cycle Phase Transition Cysteine Biosynthetic Process From Serine Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Homocysteine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Negative Regulation Of Cell Differentiation Organelle Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Synaptic Growth At Neuromuscular Junction Mast Cell Secretory Granule Organization Transsulfuration Regulation Of Mitotic Cell Cycle Vacuole Organization Collateral Sprouting In Absence Of Injury Cysteine Biosynthetic Process L-cysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle L-serine Catabolic Process Pentose-phosphate Shunt, Non-oxidative Branch Regulation Of Cell Cycle Process Positive Regulation Of NK T Cell Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Hydrogen Sulfide Metabolic Process Positive Regulation Of Peptidase Activity Endosome Transport Via Multivesicular Body Sorting Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Male Germ-line Stem Cell Asymmetric Division Regulation Of Cellular Protein Metabolic Process Axon Choice Point Recognition Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine Metabolic Process Secretion Of Lysosomal Enzymes Positive Regulation Of Cell Death Protein Modification By Small Protein Conjugation Regulation Of Response To Osmotic Stress Regulation Of Mitotic Spindle Assembly Regulation Of Signaling Homocysteine Metabolic Process Phospholipid Homeostasis Neuron Remodeling	Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Metaphase Plate Congression Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Establishment Of Chromosome Localization Viral Budding Regulation Of Spindle Assembly Regulation Of Mitotic Spindle Organization Viral Life Cycle Cell Division Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Virion Assembly Nucleus Organization Negative Regulation Of Autophagic Vacuole Assembly Establishment Of Organelle Localization Mitotic Cell Cycle Process Regulation Of Centrosome Duplication Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Centrosome Cycle Mitotic Cell Cycle Organelle Localization Endosomal Transport Cell Cycle Posttranslational Protein Targeting To Membrane Positive Regulation Of Viral Release From Host Cell Establishment Of Localization In Cell Protein Transport Chromosome Segregation Positive Regulation Of Viral Process Establishment Of Protein Localization Vacuolar Transport Viral Process Membrane Budding Intracellular Transport Cell Cycle Process Negative Regulation Of Macroautophagy Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Localization Mitotic Nuclear Division Cytokinesis Regulation Of Autophagic Vacuole Assembly Regulation Of Mitotic Nuclear Division Regulation Of Vacuole Organization Protein Localization To Endoplasmic Reticulum Protein Localization Regulation Of Viral Release From Host Cell Regulation Of Microtubule Cytoskeleton Organization
Tagcloud ?		abscission atpase budding carboxyl cofactor compensatory coordinating cytokinesis endosomal enveloped escrt escrts helices hydrolysis input intergenic lip5 modulates multivesicular oligomer oligomerization rational sbp sorting stimulatory uncovered vps4 vse vsl	associate avian beyond budding coactivator conjugation dimer e3 endosome escrt evolved fusions gag hexamer homologue inability interferes isg15 leukosis lip5 probable rescued retroviruses sarcoma scission sorting tsg101 ubiquitin vps4
Tagcloud (Difference) ?		abscission atpase carboxyl cofactor compensatory coordinating cytokinesis endosomal enveloped escrts helices hydrolysis input intergenic modulates multivesicular oligomer oligomerization rational sbp stimulatory uncovered vse vsl	associate avian beyond coactivator conjugation dimer e3 endosome evolved fusions gag hexamer homologue inability interferes isg15 leukosis probable rescued retroviruses sarcoma scission tsg101 ubiquitin
Tagcloud (Intersection) ?		budding escrt lip5 sorting vps4