VTA1 and CHMP5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		VTA1	CHMP5
Description		vesicle trafficking 1	charged multivesicular body protein 5
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Multivesicular Body Cytosol Endosome Membrane Membrane Extracellular Exosome	Autophagosome Membrane Kinetochore ESCRT III Complex Nucleus Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Endosome Membrane Membrane Midbody Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane
	Molecular Function	Protein Binding	Protein Binding Cadherin Binding
	Biological Process	Protein Transport Macroautophagy Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Sorting Pathway ESCRT III Complex Disassembly	Plasma Membrane Repair Regulation Of Receptor Recycling Vesicle Budding From Membrane Autophagy Nucleus Organization Vacuolar Transport Lysosome Organization Mitotic Metaphase Chromosome Alignment Endosome To Lysosome Transport Regulation Of Centrosome Duplication Protein Transport Erythrocyte Differentiation Nuclear Membrane Reassembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding Viral Budding From Plasma Membrane Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)	Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) FEV1 ( 30804560) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Retinal vascular caliber ( 21060863) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erectile dysfunction and prostate cancer treatment ( 20932654)
Interacting Genes		22 interacting genes: APP BEX3 CBS CCNC CDK4 CHMP1A CHMP5 DPPA2 ERBB3 KCTD13 KLHL12 LYST MAGEA11 MBIP NBR1 NECAB2 RABAC1 RPIA SNCA TEAD4 ZBTB16 ZNRD2	17 interacting genes: APPBP2 CEBPA CHMP1B CHMP4A CHMP4B GTF3A MITD1 NOD2 PDCD10 RPL38 SMARCA4 STAMBP URGCP VPS4B VTA1 ZNF142 ZNF91
Entrez ID		51534	51510
HPRD ID		09855	15408
Ensembl ID		ENSG00000009844	ENSG00000086065
Uniprot IDs		A0A087WY55 Q9NP79	Q9NZZ3
PDB IDs		2LXL 2LXM 4TXP 4TXQ 4TXR 4U7E	2LXM 3ULY 3UM0 3UM1 3UM2 4TXR
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Regulation Of MAPK Cascade ESCRT III Complex Viral Budding From Plasma Membrane Amphisome Membrane Lysosomal Membrane Organization Vesicle Fusion With Vacuole ESCRT III Complex Disassembly ESCRT Complex Disassembly Multivesicular Body-lysosome Fusion Protein Domain Specific Binding Presynapse Regulation Of Neurotransmitter Uptake Late Endosome To Lysosome Transport Kinetochore Microtubule Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Amyloid Fibril Formation Cytoplasm Cellular Response To Copper Ion Lysosomal Transport Vesicle Organization Plasma Membrane Repair Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Budding Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell Midbody Abscission Regulation Of Receptor Recycling Microglial Cell Activation Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Synaptic Transmission Leukocyte Activation Involved In Inflammatory Response Multivesicular Body Organization Multivesicular Body Assembly Regulation Of Spindle Assembly Response To Copper Ion Regulation Of JNK Cascade Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding	Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Midbody Abscission Mitotic Cytokinetic Process Viral Budding Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Cytokinetic Process Viral Budding From Plasma Membrane Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Protein-containing Complex Disassembly Regulation Of Mitotic Spindle Assembly Nuclear Membrane Reassembly Chromosome Localization Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Release From Host Cell Endosome Organization Nuclear Pore Nucleus Organization Regulation Of Spindle Assembly Regulation Of Mitotic Spindle Organization ESCRT III Complex Disassembly ESCRT Complex Disassembly Membrane Fission Mitotic Metaphase Chromosome Alignment ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Nuclear Membrane Organization Multivesicular Body-lysosome Fusion Autophagosome Maturation Lysosomal Membrane Organization Metaphase Chromosome Alignment Membrane Assembly Viral Process Late Endosome Membrane Autophagy Kinetochore Endosome Vacuolar Transport Kinetochore Microtubule Midbody Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Membrane Membrane Coat Endosomal Transport
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