VTA1 and TEAD4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VTA1	TEAD4
Description		vesicle trafficking 1	TEA domain transcription factor 4
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Multivesicular Body Cytosol Endosome Membrane Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-DNA Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Protein Transport Macroautophagy Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Sorting Pathway ESCRT III Complex Disassembly	Skeletal System Development In Utero Embryonic Development Cell Fate Specification Blastocyst Formation Trophectodermal Cell Fate Commitment DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Embryo Implantation Hippo Signaling Cell Fate Commitment Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Positive Regulation Of Stem Cell Population Maintenance
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Zygotic genome activation (ZGA) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) FEV1 ( 30804560) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Retinal vascular caliber ( 21060863) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Narcolepsy with cataplexy ( 23496005)
Interacting Genes		22 interacting genes: APP BEX3 CBS CCNC CDK4 CHMP1A CHMP5 DPPA2 ERBB3 KCTD13 KLHL12 LYST MAGEA11 MBIP NBR1 NECAB2 RABAC1 RPIA SNCA TEAD4 ZBTB16 ZNRD2	50 interacting genes: CCDC125 CCDC172 CCDC85B CCNDBP1 CDR2 CEP55 CEP70 CRYAA CTBP1 DYDC1 EXOC3-AS1 FBXO7 GOLGA2 GOLGA6L9 HAUS1 HOMEZ INCA1 KIAA0753 KRT27 KRT31 KRT40 KRTAP10-3 LDOC1 LZTS2 MDFI MTUS2 MYH7 NUTM1 PDE4DIP PFKM PNMA1 PRDM14 PRKAR1B RABGEF1 RASSF10 RUNDC3A RUNX1 SAT1 SESTD1 SORBS3 SSX2IP TLE5 TRAF1 TRIM54 VGLL1 VGLL3 VPS52 VTA1 WWTR1 YAP1
Entrez ID		51534	7004
HPRD ID		09855	03421
Ensembl ID		ENSG00000009844	ENSG00000197905
Uniprot IDs		A0A087WY55 Q9NP79	Q15561
PDB IDs		2LXL 2LXM 4TXP 4TXQ 4TXR 4U7E	5GZB 5NO6 5OAQ 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6Q2X 6Q36 6SEN 6SEO 8A8R 8C17 8CAA
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Regulation Of MAPK Cascade ESCRT III Complex Viral Budding From Plasma Membrane Amphisome Membrane Lysosomal Membrane Organization Vesicle Fusion With Vacuole ESCRT III Complex Disassembly ESCRT Complex Disassembly Multivesicular Body-lysosome Fusion Protein Domain Specific Binding Presynapse Regulation Of Neurotransmitter Uptake Late Endosome To Lysosome Transport Kinetochore Microtubule Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Amyloid Fibril Formation Cytoplasm Cellular Response To Copper Ion Lysosomal Transport Vesicle Organization Plasma Membrane Repair Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Budding Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell Midbody Abscission Regulation Of Receptor Recycling Microglial Cell Activation Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Synaptic Transmission Leukocyte Activation Involved In Inflammatory Response Multivesicular Body Organization Multivesicular Body Assembly Regulation Of Spindle Assembly Response To Copper Ion Regulation Of JNK Cascade Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding	Cytoskeleton Microtubule Organizing Center Organization Centrosome Cycle Centrosome Cytoplasm Cardiac Muscle Tissue Regeneration Protein Binding Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Keratin Filament
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