SERF2 and THAP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SERF2	THAP1
Description		small EDRK-rich factor 2	THAP domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body
	Molecular Function		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein Destabilization	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle
Pathways
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS			Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		18 interacting genes: BOLL CEBPA CHD3 DAB1 GC KRTAP10-3 MDFI NELFCD PSMA3 PSME3 PTPN11 QKI RBPMS RHOXF2 SP4 THAP1 UPF2 WT1	105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526
Entrez ID		10169	55145
HPRD ID		05447	15496
Ensembl ID		ENSG00000140264	ENSG00000131931
Uniprot IDs		P84101	Q9NVV9
PDB IDs			2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Glial Cell Differentiation Identical Protein Binding Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Astrocyte Differentiation Nucleus RNA Binding Astrocyte Differentiation Macrophage Differentiation Regulation Of Primary Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Calcidiol Binding Negative Regulation Of Cortisol Secretion Genitalia Development Negative Regulation Of Growth Hormone Secretion Negative Regulation Of Type I Interferon Production Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of Gene Expression Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Cell Development Animal Organ Regeneration Response To Vitamin B2 C/EBP Complex Negative Regulation Of RNA Biosynthetic Process Inner Ear Development Cerebellum Structural Organization Developmental Process Involved In Reproduction Proteasome Complex Intestinal Epithelial Cell Migration Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Myofibroblast Contraction	Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation
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