SERF2 and GC

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SERF2	GC
Description		small EDRK-rich factor 2	GC vitamin D binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Extracellular Region Extracellular Space Cytoplasm Cytosol Lysosomal Lumen Extracellular Exosome Blood Microparticle
	Molecular Function		Actin Binding Vitamin D Binding Vitamin Transmembrane Transporter Activity Calcidiol Binding
	Biological Process	Protein Destabilization	Response To Nutrient Levels Vitamin Transmembrane Transport Vitamin D Metabolic Process Vitamin Transport
Pathways			Vitamin D (calciferol) metabolism
Drugs			Vitamin D
Diseases
GWAS			Bioavailable vitamin D levels in type 2 diabetes ( 34014961) Granulocyte count ( 27863252) Lymphocyte count ( 32888494) Metabolite levels ( 22916037) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Neutrophil count ( 27863252 32888494) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum 25-Hydroxyvitamin D levels ( 29325163 29545823 31841498 33382404) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum vitamin D-binding protein levels ( 24740207) Serum vitamin D-binding protein levels in type 2 diabetes ( 34014961) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 29343764 25208829 22673963 20418485) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764) White blood cell count ( 27863252 32888494)
Interacting Genes		18 interacting genes: BOLL CEBPA CHD3 DAB1 GC KRTAP10-3 MDFI NELFCD PSMA3 PSME3 PTPN11 QKI RBPMS RHOXF2 SP4 THAP1 UPF2 WT1	13 interacting genes: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 HSP90AA1 LRIF1 LRP2 PIK3R3 SERF2
Entrez ID		10169	2638
HPRD ID		05447	00749
Ensembl ID		ENSG00000140264	ENSG00000145321
Uniprot IDs		P84101	P02774
PDB IDs			1J78 1J7E 1KW2 1KXP 1LOT 1MA9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Glial Cell Differentiation Identical Protein Binding Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Astrocyte Differentiation Nucleus RNA Binding Astrocyte Differentiation Macrophage Differentiation Regulation Of Primary Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Calcidiol Binding Negative Regulation Of Cortisol Secretion Genitalia Development Negative Regulation Of Growth Hormone Secretion Negative Regulation Of Type I Interferon Production Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of Gene Expression Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Cell Development Animal Organ Regeneration Response To Vitamin B2 C/EBP Complex Negative Regulation Of RNA Biosynthetic Process Inner Ear Development Cerebellum Structural Organization Developmental Process Involved In Reproduction Proteasome Complex Intestinal Epithelial Cell Migration Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Myofibroblast Contraction	Mesenchyme Migration Brush Border Membrane Filopodium Extracellular Exosome Skeletal Muscle Thin Filament Assembly Muscle Contraction Cobalamin Transport Muscle System Process Cell Body Apical Part Of Cell Actin Cytoskeleton Circulatory System Process Blood Microparticle Regulation Of Metabolic Process Myosin Binding Apical Plasma Membrane Cargo Receptor Activity Amyloid-beta Clearance Positive Regulation Of Gene Expression Microvillus Membrane Tissue Morphogenesis Response To External Biotic Stimulus Receptor-mediated Endocytosis Regulation Of Macromolecule Metabolic Process Lamellipodium Positive Regulation Of Metabolic Process Lymphocyte Activation Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Vitamin Transport System Process Regulation Of Programmed Cell Death Phosphotyrosine Residue Binding Positive Regulation Of Hepatic Stellate Cell Contraction C5L2 Anaphylatoxin Chemotactic Receptor Binding Guanyl-nucleotide Exchange Factor Adaptor Activity CTP Binding DATP Binding Renal Phosphate Ion Absorption Leukocyte Activation Sarcomere Cardiac Muscle Tissue Morphogenesis Regulation Of Cellular Component Size Brush Border Protein Destabilization Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Hepatic Stellate Cell Migration Response To Other Organism Vascular Process In Circulatory System
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