SERF2 and UPF2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		SERF2	UPF2
Description		small EDRK-rich factor 2	UPF2 regulator of nonsense mediated mRNA decay
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function		RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Protein Destabilization	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways			Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Diverticular disease ( 30177863)
Interacting Genes		18 interacting genes: BOLL CEBPA CHD3 DAB1 GC KRTAP10-3 MDFI NELFCD PSMA3 PSME3 PTPN11 QKI RBPMS RHOXF2 SP4 THAP1 UPF2 WT1	76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		10169	26019
HPRD ID		05447	10405
Ensembl ID		ENSG00000140264	ENSG00000151461
Uniprot IDs		P84101	Q9HAU5
PDB IDs			1UW4 2WJV 4CEK 4CEM 7NWU 7QG6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Glial Cell Differentiation Identical Protein Binding Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Astrocyte Differentiation Nucleus RNA Binding Astrocyte Differentiation Macrophage Differentiation Regulation Of Primary Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Calcidiol Binding Negative Regulation Of Cortisol Secretion Genitalia Development Negative Regulation Of Growth Hormone Secretion Negative Regulation Of Type I Interferon Production Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of Gene Expression Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Cell Development Animal Organ Regeneration Response To Vitamin B2 C/EBP Complex Negative Regulation Of RNA Biosynthetic Process Inner Ear Development Cerebellum Structural Organization Developmental Process Involved In Reproduction Proteasome Complex Intestinal Epithelial Cell Migration Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Myofibroblast Contraction	RNA Binding Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process RRNA Metabolic Process RRNA Processing Nucleic Acid Metabolic Process Exosome (RNase Complex) Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Histone MRNA Catabolic Process Nuclear Exosome (RNase Complex) Negative Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Biosynthetic Process Nuclear MRNA Surveillance Ribosome Histone MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Processing Ribosomal Small Subunit Biogenesis Translation Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleolus Nucleic Acid Binding Cytosolic Ribosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Regulation Of Metabolic Process Nuclear RNA Surveillance RRNA Catabolic Process RNA Surveillance DNA Metabolic Process Cytosol Cytoplasmic Translation Negative Regulation Of Protein Metabolic Process Macromolecule Catabolic Process
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