SERF2 and NELFCD

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SERF2	NELFCD
Gene Name		small EDRK-rich factor 2	negative elongation factor complex member C/D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Nucleoplasm Membrane NELF Complex
	Molecular Function	Molecular_function	Protein Binding
	Biological Process	Biological_process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription
Pathways			Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: BOLL CHD3 DAB1 GC KRTAP10-3 MDFI NELFCD PSMA3 PSME3 QKI RBPMS RHOXF2 SP4 THAP1 UPF2	19 interactors: AAMP AR ARAF ARPC4 CACNA1A DNAJA1 ENDOV EPRS FRMD5 GSTM4 HDAC11 MTA1 NELFA PRMT5 SERF2 SMAD4 TXK UBE3A ZNF638
Entrez ID		10169	51497
HPRD ID		05447	16096
Ensembl ID			ENSG00000101158
Uniprot IDs		P84101	H0UI80 Q8IXH7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Gene Expression Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Negative Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Regulation Of Cellular Process DNA Damage Response, Signal Transduction By P53 Class Mediator RNA Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cerebellum Structural Organization 3'-UTR-mediated MRNA Destabilization Glucosylceramide Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint	Androgen Receptor Signaling Pathway Endothelial Cell Activation Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Growth Regulation Of Protein Ubiquitination Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Negative Regulation Of Integrin Biosynthetic Process Cerebellar Molecular Layer Development Sperm Entry Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stimulus Cellular Metabolic Process Prostate Gland Development Heterocycle Metabolic Process Biosynthetic Process Prolyl-tRNA Aminoacylation Vestibular Nucleus Development Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Nephrogenic Mesenchyme Morphogenesis Positive Regulation Of Protein Autoubiquitination Regulation Of Establishment Of Protein Localization Rhythmic Process Circadian Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Glutamyl-tRNA Aminoacylation Positive Regulation Of Integrin Biosynthetic Process Cerebellum Maturation Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Musculoskeletal Movement, Spinal Reflex Action Regulation Of Protein Autoubiquitination NK T Cell Differentiation Positive Regulation Of Cellular Metabolic Process Cellular Component Assembly
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