ARFRP1 and AP1G1

Number of citations of the paper that reports this interaction (PubMedID 23326640)
62

Data Source:
BioGRID (pull down)

		ARFRP1	AP1G1
Description		ARF related protein 1	adaptor related protein complex 1 subunit gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cytosol Membrane Trans-Golgi Network Membrane	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Clathrin-coated Pit Membrane Membrane Coat AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Intracellular Vesicle Presynapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Protein Binding Collagen Binding Kinesin Binding GTP-dependent Protein Binding Small GTPase Binding Clathrin Adaptor Activity
	Biological Process	Intracellular Protein Transport Signal Transduction Gastrulation Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport	Intracellular Protein Transport Golgi To Vacuole Transport Protein Transport Synaptic Vesicle Budding From Endosome Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Synaptic Vesicle Endocytosis Platelet Dense Granule Organization Golgi To Lysosome Transport Basolateral Protein Secretion Melanosome Assembly
Pathways		Retrograde transport at the Trans-Golgi-Network Retrograde transport at the Trans-Golgi-Network	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 30604766) Inflammatory bowel disease ( 28067908) Platelet count ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Ulcerative colitis ( 28067908)	General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Post bronchodilator FEV1 ( 26634245) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		6 interacting genes: AP1G1 AP1M1 CYTH1 GLP1R SMAD4 VANGL2	30 interacting genes: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 ARFRP1 BAALC CCDC91 CLINT1 CLTC DNER EPS15 GGA1 GGA2 GGA3 HEATR5B KIF13A MAP1A PLK2 PSEN2 RABEP1 RABGEF1 SNX9 SPTB SYNRG SYP UBL7 ZNF512B
Entrez ID		10139	164
HPRD ID		05264	04637
Ensembl ID		ENSG00000101246	ENSG00000166747
Uniprot IDs		A0A384P5U7 B7ZKY8 Q13795	A0A140VJE7 O43747 Q8IY97
PDB IDs			1IU1
Enriched GO Terms of Interacting Partners?		Endosome To Melanosome Transport AP-1 Adaptor Complex Clathrin Adaptor Activity Melanosome Assembly Platelet Dense Granule Organization Clathrin-coated Vesicle Membrane Melanosome Organization Pigment Granule Organization Collagen Binding Clathrin-coated Vesicle Secretory Granule Organization Glucagon-like Peptide 1 Receptor Activity Muscle Tissue Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Synaptic Vesicle Budding From Endosome Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Trans-Golgi Network Membrane Intracellular Protein Transport Glucagon Receptor Activity Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Serotonergic Neuron Axon Guidance Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Basolateral Protein Secretion Golgi Membrane Positive Regulation Of Natural Killer Cell Degranulation Cytoplasmic Vesicle Membrane Response To Psychosocial Stress Positive Regulation Of Luteinizing Hormone Secretion Anterior/posterior Pattern Specification Sulfate Binding Endocardial Cell Differentiation Establishment Or Maintenance Of Cell Polarity Apical Cytoplasm Convergent Extension Involved In Organogenesis Establishment Of Body Hair Planar Orientation Establishment Of Planar Polarity Of Embryonic Epithelium Axonemal Central Apparatus Assembly	Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Cellular Localization Clathrin-coated Vesicle AP-1 Adaptor Complex Intracellular Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Golgi Apparatus Early Endosome Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Membrane Endocytosis Endosomal Transport Golgi To Plasma Membrane Transport Cytosolic Transport Vesicle-mediated Transport To The Plasma Membrane Golgi To Plasma Membrane Protein Transport Import Into Cell Cytoplasmic Vesicle Golgi Vesicle Transport Trans-Golgi Network Establishment Of Protein Localization To Plasma Membrane Basolateral Protein Secretion Clathrin-coated Pit Clathrin Binding Endosome Melanosome Organization Cytoplasmic Vesicle Membrane Pigment Granule Organization Retrograde Transport, Endosome To Golgi Cytosol Early Endosome Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Localization Within Membrane Melanosome Assembly Clathrin Adaptor Activity Clathrin Coat Assembly Platelet Dense Granule Organization Receptor-mediated Endocytosis Protein Localization To Membrane Vesicle Organization Membrane Coat Protein Localization To Cell Surface Protein Localization To Plasma Membrane Ubiquitin Binding Phosphatidylinositol Binding
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