ARFRP1 and GLP1R

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay)

		ARFRP1	GLP1R
Gene Name		ADP-ribosylation factor related protein 1	glucagon-like peptide 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Gastrulation Metabolic Process Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: CYTH1 GLP1R SMAD4	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		10139	2740
HPRD ID		05264	00677
Ensembl ID		ENSG00000101246	ENSG00000112164
Uniprot IDs		B7ZKY8 Q13795	P43220
PDB IDs			3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Nephrogenic Mesenchyme Morphogenesis Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Endocardial Cell Differentiation Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Brainstem Development SMAD Protein Complex Assembly Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Canal Development Regulation Of Hair Follicle Development Heart Valve Formation Metanephric Mesenchyme Development Endocardial Cushion Formation Endocardium Development Establishment Of Epithelial Cell Polarity Regulation Of Protein Transport Atrioventricular Valve Morphogenesis Regulation Of Signaling Regulation Of Hair Cycle Regulation Of Establishment Of Protein Localization Endocardial Cushion Morphogenesis Atrioventricular Valve Development CAMP-mediated Signaling Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Heart Morphogenesis Activation Of Adenylate Cyclase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Heart Valve Morphogenesis Cyclic-nucleotide-mediated Signaling Heart Valve Development Endocardial Cushion Development Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of BMP Signaling Pathway Cellular Response To Glucagon Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Lyase Activity Embryonic Axis Specification	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?			2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?			2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Intersection) ?