ARFRP1 and CYTH1

Number of citations of the paper that reports this interaction (PMID 10092663)
5

Data Source:
HPRD (in vitro, two hybrid)

		ARFRP1	CYTH1
Gene Name		ADP-ribosylation factor related protein 1	cytohesin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Membrane	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Tight Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding	ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Gastrulation Metabolic Process Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport	Vesicle-mediated Transport Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Polarity
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: CYTH1 GLP1R SMAD4	12 interactors: ACTA1 ARF1 ARF6 ARFRP1 ARR3 CYTIP GNAQ IPCEF1 ITGB2 ITSN1 PRKCD TRIM23
Entrez ID		10139	9267
HPRD ID		05264	01630
Ensembl ID		ENSG00000101246	ENSG00000108669
Uniprot IDs		B7ZKY8 Q13795	Q15438
PDB IDs			1BC9 4A4P
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Nephrogenic Mesenchyme Morphogenesis Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Endocardial Cell Differentiation Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Brainstem Development SMAD Protein Complex Assembly Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Canal Development Regulation Of Hair Follicle Development Heart Valve Formation Metanephric Mesenchyme Development Endocardial Cushion Formation Endocardium Development Establishment Of Epithelial Cell Polarity Regulation Of Protein Transport Atrioventricular Valve Morphogenesis Regulation Of Signaling Regulation Of Hair Cycle Regulation Of Establishment Of Protein Localization Endocardial Cushion Morphogenesis Atrioventricular Valve Development CAMP-mediated Signaling Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Heart Morphogenesis Activation Of Adenylate Cyclase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Heart Valve Morphogenesis Cyclic-nucleotide-mediated Signaling Heart Valve Development Endocardial Cushion Development Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of BMP Signaling Pathway Cellular Response To Glucagon Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Lyase Activity Embryonic Axis Specification	Small GTPase Mediated Signal Transduction Vesicle-mediated Transport Response To Stimulus Cellular Response To Stimulus Signal Transduction Intracellular Signal Transduction Signaling Regulation Of Filopodium Assembly Regulation Of Phosphorylation Cell Communication Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Phospholipase Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Post-Golgi Vesicle-mediated Transport Positive Regulation Of Lipase Activity Regulation Of Actin Filament-based Process Protein Stabilization Positive Regulation Of Phospholipid Catabolic Process Skeletal Muscle Fiber Adaptation Apoptotic Process Blood Coagulation Hemostasis Programmed Cell Death Lymphocyte Proliferation Cell Death Mononuclear Cell Proliferation Death Regulation Of Protein Phosphorylation Interleukin-10 Production Regulation Of Cell Projection Assembly Leukocyte Proliferation Regulation Of Cytoskeleton Organization Negative Regulation Of Filopodium Assembly Regulation Of Protein Stability Interleukin-12 Production Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Ceramide Biosynthetic Process Wound Healing Skeletal Muscle Thin Filament Assembly Regulation Of Actin Filament Polymerization Embryonic Morphogenesis Endocytosis
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