CDH10 and COPS6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDH10	COPS6
Description		cadherin 10	COP9 signalosome subunit 6
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Membrane Catenin Complex Synapse Presynaptic Active Zone Membrane Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding	Protein Binding Peptidase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Cell-cell Adhesion Synaptic Membrane Adhesion	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation
Pathways		Adherens junctions interactions	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Anorexia nervosa ( 31308545) Autism ( 19404256) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels in HIV infection ( 33109212) Hepcidin/ferritin ratio ( 27846281) Idiopathic dilated cardiomyopathy ( 29495422) Obsessive-compulsive disorder ( 24821223) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: CDH6 CDH9 COPS6 JUP PTN	95 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CRIPTO CUL1 CUL5 DIS3L2 DLEU1 DSP EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHANK3 SHC3 SLC2A1 SMN1 SNRPG STAMBPL1 STK40 STX5 SULT1E1 TK1 TP53 TP63 TRDMT1 TRIB3 UBC USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24
Entrez ID		1008	10980
HPRD ID		05187	16735
Ensembl ID		ENSG00000040731	ENSG00000168090
Uniprot IDs		Q9Y6N8 X5D8X5 X5DNG6	Q7L5N1
PDB IDs			4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Catenin Complex Cell-cell Junction Assembly Cell-cell Junction Organization Adherens Junction Synaptic Membrane Adhesion Cell Junction Assembly Cell Migration Cell-cell Adhesion Mediated By Cadherin Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cadherin Binding Cell Motility Adherens Junction Organization Cell Junction Organization Cell-cell Adhesion Gamma-catenin-TCF7L2 Complex Beta-catenin Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Dendrite Regeneration Catenin-TCF7L2 Complex Ossification Involved In Bone Remodeling Cell Morphogenesis Cell Adhesion Cytoskeletal Protein-membrane Anchor Activity Endothelial Cell-cell Adhesion Regulation Of Endothelial Cell Migration Response To Mechanical Stimulus Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cellular Response To Indole-3-methanol Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Response To Indole-3-methanol Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Hemidesmosome Zonula Adherens Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Axon Regeneration Alpha-catenin Binding Chondroitin Sulfate Binding Positive Regulation Of Hepatocyte Proliferation Protein Localization To Membrane Estrous Cycle Protein Deneddylation Regulation Of Ventricular Cardiac Muscle Cell Action Potential Dendrite Arborization Negative Regulation Of Long-term Synaptic Potentiation Metal-dependent Deubiquitinase Activity Negative Regulation Of Neuroblast Proliferation Desmosome Organization	Protein Neddylation Protein Deneddylation Regulation Of Protein Neddylation Nucleoplasm Heart Development COP9 Signalosome Developmental Process Cytosol Cellular Response To Staurosporine Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Protein Binding Positive Regulation Of Neuron Apoptotic Process Protease Binding Pyroptotic Inflammatory Response Protein Modification By Small Protein Removal Nucleus Animal Organ Development Regulation Of Cell Cycle G1/S Phase Transition Cytoplasm Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Developmental Process Cell Differentiation Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Scaffold Protein Binding MAPK Cascade Cellular Response To Alkaloid Regulation Of Protein Modification Process Positive Regulation Of Programmed Cell Death Post-translational Protein Modification Protein Modification Process Regulation Of Post-translational Protein Modification Protein Tag Activity Cullin-RING Ubiquitin Ligase Complex Protein-containing Complex Cellular Response To Starvation Response To Nutrient Levels Mitotic G1 DNA Damage Checkpoint Signaling Rhythmic Synaptic Transmission G1/S Transition Of Mitotic Cell Cycle Mitotic G1/S Transition Checkpoint Signaling
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