SH2D3A and BCAR1

Number of citations of the paper that reports this interaction (PMID 10187783)
18

Data Source:
HPRD (in vivo)

		SH2D3A	BCAR1
Gene Name		SH2 domain containing 3A	breast cancer anti-estrogen resistance 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium
	Molecular Function	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of GTPase Activity	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis
Pathways			Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		4 interactors: BCAR1 EGFR ERBB2 NXF1	52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ
Entrez ID		10045	9564
HPRD ID		05283	04248
Ensembl ID		ENSG00000125731	ENSG00000050820
Uniprot IDs		A8K2M8 B4DRS7 Q9BRG2	B2RBL9 B3KWE2 F5H855 P56945
PDB IDs			1WYX 3T6G
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cellular Response To Growth Factor Stimulus Chemotaxis Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Proliferation Alkanesulfonate Metabolic Process Regulation Of Immune Response Phosphatidylinositol-mediated Signaling Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Glial Cell Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Protein Autophosphorylation Positive Regulation Of MAP Kinase Activity Fc-epsilon Receptor Signaling Pathway Locomotion Gliogenesis Negative Regulation Of Immature T Cell Proliferation In Thymus Activation Of Phospholipase A2 Activity Regulation Of Immune System Process Fc Receptor Signaling Pathway Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Regulation Of Epithelial Cell Proliferation Regulation Of MAP Kinase Activity Response To Cobalamin Response To UV-A Movement Of Cell Or Subcellular Component Response To Hydroxyisoflavone Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cellular Component Movement Regulation Of Cell Growth Positive Regulation Of Locomotion	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling
Tagcloud ?			aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?			aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?